Horm Metab Res
DOI: 10.1055/a-1941-8556
Original Article: Endocrine Care
1
Key Laboratory of Endocrinology of National Health Commission,
Department of Endocrinology, Peking Union Medical College Hospital, Chinese
Academy of Medical Science and Peking Union Medical College, Beijing,
China
,
1
Key Laboratory of Endocrinology of National Health Commission,
Department of Endocrinology, Peking Union Medical College Hospital, Chinese
Academy of Medical Science and Peking Union Medical College, Beijing,
China
,
Linjie Wang
1
Key Laboratory of Endocrinology of National Health Commission,
Department of Endocrinology, Peking Union Medical College Hospital, Chinese
Academy of Medical Science and Peking Union Medical College, Beijing,
China
,
Lian Duan
1
Key Laboratory of Endocrinology of National Health Commission,
Department of Endocrinology, Peking Union Medical College Hospital, Chinese
Academy of Medical Science and Peking Union Medical College, Beijing,
China
,
Fengying Gong
1
Key Laboratory of Endocrinology of National Health Commission,
Department of Endocrinology, Peking Union Medical College Hospital, Chinese
Academy of Medical Science and Peking Union Medical College, Beijing,
China
,
Huijuan Zhu
1
Key Laboratory of Endocrinology of National Health Commission,
Department of Endocrinology, Peking Union Medical College Hospital, Chinese
Academy of Medical Science and Peking Union Medical College, Beijing,
China
,
Hui Pan
1
Key Laboratory of Endocrinology of National Health Commission,
Department of Endocrinology, Peking Union Medical College Hospital, Chinese
Academy of Medical Science and Peking Union Medical College, Beijing,
China
› Author Affiliations
Funding Information
This work was supported by National High Level Hospital Clinical
Research Funding (2022-PUMCH-A-249) and National Natural
Science Foundation of China (81970678).
› Further Information
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Abstract
Adult growth hormone deficiency (AGHD) is associated with increased
cardiovascular risks. The primary endpoint of this retrospective cohort study
was to compare metabolic profile and echocardiographic parameters in
childhood-onset (CO) and adulthood-onset (AO) AGHD patients. 26 patients with CO
AGHD (19 males, 26.8±8.5 years) and 41 patients with AO AGHD (23 males,
35.1±6.8 years) were included. The standard deviation score of
insulin-like growth factor-1 (IGF-1 SDS), metabolic profile, liver sonography
and echocardiographic parameters were compared. The IGF-1 SDS were significantly
lower in CO AGHD patients (p<0.05). AO AGHD patients showed much
profound glycolipid aberrations, elevated C-reactive protein levels
(p=0.012), and proportionally higher prevalence of non-alcoholic fatty
liver disease (95.2% vs.8.3%, p<0.001). In all subjects,
IGF-1 SDS was negatively related to low-density lipoprotein cholesterol, and
positively related to total cholesterol and lipoprotein a (Lpa). There were
significant differences between the two group with regard to the correlations
between IGF-1 SDS and high-density lipoprotein cholesterol, low-density
lipoprotein cholesterol, LPa, uric acid and creatinine (all p for
interaction<0.05). CO AGHD patients exhibited smaller heart, but similar
ventricular ejection fraction compared to AO AGHD patients. AGHD may be a group
of heterogenous entity based on the onset ages of disease. AO patients had
prominent metabolic disorders, while CO patients had smaller heart but similar
cardiac performance. Whether growth hormone replacement therapy will equally
benefit both CO and AO AGHD patients needs further investigations.
Key words
adult growth hormone deficiency -
cardiac function -
metabolic profile -
childhood-onset -
adulthood-onset
* These authors conrtibuted equally.
Publication History
Received: 01 June 2022
Accepted after revision: 09 September 2022
Article published online:
18 October 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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