From the aPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil

bMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom

cDepartment of Statistical Sciences, University of Toronto, Toronto, ON, Canada

dPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

eK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Submitted August 23, 2021; accepted July 18, 2022

This manuscript was previously published in aRxiv:2107.01070.

The Medical Research Council and the University of Bristol support the Medical Research Council Integrative Epidemiology Unit [MC_UU_00011/1/2]. Dr. Davies is supported by a Norwegian Research Council Grant number 295989. Dr. Wang is partially supported by a McLaughlin Accelerator Grant in Genomic Medicine.

The authors report no conflicts of interest.

This work is dedicated to the memory of Mr. Dari Hartwig (FPH’s father).

Correspondence: Fernando Pires Hartwig, Postgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro 1160 (3rd floor), 96020-220 Pelotas, Brazil. E-mail: [email protected].