Prolotherapy

Hauser R.A. Lackner J.B. Steilen-Matias D. et al.

A systematic review of dextrose prolotherapy for chronic musculoskeletal pain.

Clin Med Insights Arthritis Musculoskelet Disord. 9 (): 139-159American Academy of Orthopaedic Surgeons

The burden of musculoskeletal diseases in the united states: prevalence, societal, and economic cost.

Am Acad Orthopaedic Surgeons. 208

Prolotherapy.

J Pain Palliat Care Pharmacother. 26: 376-378DeChellis D.M. Cortazzo M.H.

Regenerative medicine in the field of pain medicine: Prolotherapy, platelet-rich plasma therapy, and stem cell therapy—Theory and evidence. Techniques in Regional Anesthesia and Pain.

Management. 15: 74-80Rabago D. Slattengren A. Zgierska A.

Prolotherapy IN PRIMARY CARE PRACTICE.

Prim Care Clin Office Pract. 37: 65-80Hackett G.S. Hemwall G.A. Montgomery G.A.

Ligament and tendon relaxation.

Charles C Thomas, Borg-Stein J. Osoria H.L. Hayano T.

Regenerative sports medicine: past, present, and future (adapted from the PASSOR Legacy Award Presentation; AAPMR; October 2016).

PM&R. 10: 1083-1105

Glucose transporters in the 21st Century.

Am J Physiology-Endocrinology Metab. 298: E141-E145

Prolotherapy: basic science, clinical studies, and technique. Pain Procedures in Clinical Practice.

2nd Ed. Hanley and Belfus Philadelphia, : 172-190Yoshii Y. Zhao C. Schmelzer J.D. et al.

The effects of hypertonic dextrose injection on connective tissue and nerve conduction through the rabbit carpal tunnel.

Arch Phys Med Rehabil. 90: 333-339Ekwueme E.C. Mohiuddin M. Yarborough J.A. et al.

Prolotherapy induces an inflammatory response in human tenocytes in vitro.

Clin Orthopaedics Relat Research®. 475: 2117-2127

Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator.

Front Endocrinol. 3: 153Stecker M.M. Stevenson M.

Effect of glucose concentration on peripheral nerve and its response to anoxia.

Muscle & nerve. 49: 370-377Topol G.A. Podesta L.A. Reeves K.D. et al.

Chondrogenic effect of intra-articular hypertonic-dextrose (prolotherapy) in severe knee osteoarthritis.

PM&R. 8: 1072-1082

Dry needling—peripheral and central considerations.

J Man Manipulative Ther. 19: 223-227Han D.S. Lee C.H. Shieh Y.D. et al.

A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain.

Pain. 163: 622-633Kietrys D.M. Palombaro K.M. Azzaretto E. et al.

Effectiveness of dry needling for upper-quarter myofascial pain: a systematic review and meta-analysis.

J Orthop Sports Phys Ther. 43: 620-634Kim H.J. Jeong T.S. Kim W.S. et al.

Comparison of histological changes in accordance with the level of dextrose-concentration in experimental prolotherapy model.

J Korean Acad Rehabil Med. 27: 935-940

Prolotherapy for tissue repair.

Translational Res. 158: 129-131Finnoff J.T. Hall M.M. Adams E. et al.

American Medical Society for Sports Medicine (AMSSM) position statement: interventional musculoskeletal ultrasound in sports medicine.

PM&R. 7: 151-168Fullerton B.D. Reeves K.D.

Ultrasonography in regenerative injection (prolotherapy) using dextrose, platelet-rich plasma, and other injectants.

Phys Med Rehabil Clin. 21: 585-605Bellapianta J. Swartz F. Lisella J. et al.

Randomized prospective evaluation of injection techniques for the treatment of lateral epicondylitis.

Orthopedics. 34: e708-e712Dagenais S. Ogunseitan O. Haldeman S. et al.

Side effects and adverse events related to intraligamentous injection of sclerosing solutions (prolotherapy) for back and neck pain: a survey of practitioners.

Arch Phys Med Rehabil. 87: 909-913

Prolotherapy: a clinical review of its role in treating chronic musculoskeletal pain.

PM R. 3https://doi.org/10.1016/j.pmrj.2011.04.003Rabago D. Lee K.S. Ryan M. et al.

Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): Results of a single-blind, pilot-level, randomized controlled trial.

Am J Phys Med Rehabil. 92: 587-596Scarpone M. Rabago D.P. Zgierska A. et al.

The efficacy of prolotherapy for lateral epicondylosis: a pilot study.

Clin J Sport Med. 18: 248-254https://doi.org/10.1097/JSShin J.Y. Seo K.M. Kim D.K. et al.

The effect of prolotherapy on lateral epicondylitis of elbow.

J Korean Acad Rehabil Med. 26: 764-768Park J.H. Song I.S. Lee J.B. et al.

Ultrasonographic findings of healing of torn tendon in the patients with lateral epicondylitis after prolotherapy.

J Korean Soc Med Ultrasound. 22: 177-183Yelland M. Rabago D. Ryan M. et al.

Prolotherapy injections and physiotherapy used singly and in combination for lateral epicondylalgia: a single-blinded randomised clinical trial.

BMC Musculoskelet Disord. 20: 509Akcay S. Gurel Kandemir N. Kaya T. et al.

Dextrose prolotherapy versus normal saline injection for the treatment of lateral epicondylopathy: a randomized controlled trial.

J Altern Complement Med. 26: 1159-1168Carayannopoulos A. Borg-Stein J. Sokolof J. et al.

Prolotherapy versus corticosteroid injections for the treatment of lateral epicondylosis: a randomized controlled trial.

PM R. 3: 706-715Apaydin H. Bazancir Z. Altay Z.

Injection therapy in patients with lateral epicondylalgia: hyaluronic acid or dextrose prolotherapy? a single-blind, randomized clinical trial.

J Altern Complement Med. 26: 1169-1175Seven M.M. Ersen O. Akpancar S. et al.

Effectiveness of prolotherapy in the treatment of chronic rotator cuff lesions.

Orthopaedics Traumatol Surg Res. 103: 427-433Bertrand H. Reeves K.D. Bennett C.J. et al.

Dextrose prolotherapy versus control injections in painful rotator cuff tendinopathy.

Arch Phys Med Rehabil. 97 (): 17-25Ryu K. Ko D. Lim G. et al.

Ultrasound-guided prolotherapy with polydeoxyribonucleotide for painful rotator cuff tendinopathy.

Pain Res Manag. 2018: 8286190Catapano M. Zhang K. Mittal N. et al.

Effectiveness of dextrose prolotherapy for rotator cuff tendinopathy: a systematic review.

PM&R. 12: 288-300Monteagudo M. de Albornoz P.M. Gutierrez B. et al.

Plantar fasciopathy: a current concepts review.

EFORT Open Rev. 3: 485-493Ersen Ö. Koca K. Akpancar S. et al.

A randomized-controlled trial of prolotherapy injections in the treatment of plantar fasciitis.

Turkish J Phys Med Rehabil. 64: 59-65Mansiz-Kaplan B. Nacir B. Pervane-Vural S. et al.

Effect of dextrose prolotherapy on pain intensity, disability, and plantar fascia thickness in unilateral plantar fasciitis: a randomized, controlled, double-blind study.

Am J Phys Med Rehabil. 99: 318-324Kesikburun S. Uran Şan A. Kesikburun B. et al.

Comparison of ultrasound-guided prolotherapy versus extracorporeal shock wave therapy in the treatment of chronic plantar fasciitis: a randomized clinical trial.

J Foot Ankle Surg. https://doi.org/10.1053/j.jfas.2021.06.007Asheghan M. Hashemi S.E. Hollisaz M.T. et al.

Dextrose prolotherapy versus radial extracorporeal shock wave therapy in the treatment of chronic plantar fasciitis: a randomized, controlled clinical trial.

Foot Ankle Surg. 27: 643-649

Autologous platelet-rich plasma versus dextrose prolotherapy for the treatment of chronic recalcitrant plantar fasciitis.

PM R. 6: 152-158Yelland M.J. Sweeting K.R. Lyftogt J.A. et al.

Prolotherapy injections and eccentric loading exercises for painful Achilles tendinosis: a randomised trial.

Br J Sports Med. 45: 421-428Maxwell N.J. Ryan M.B. Taunton J.E. et al.

Sonographically guided intratendinous injection of hyperosmolar dextrose to treat chronic tendinosis of the Achilles tendon: a pilot study 2007;189:w215–20.

AJR Am J Roentgenol. 189: 215-220Ryan M. Wong A. Taunton J.

Favorable outcomes after sonographically guided intratendinous injection of hyperosmolar dextrose for chronic insertional and midportion achilles tendinosis.

AJR Am J Roentgenol. 194: 1047-1053

Randomized, prospective, placebo-controlled double-blind study of dextrose prolotherapy for osteoarthritic thumb and finger (DIP, PIP, and Trapeziometacarpal) joints: evidence of clinical efficacy.

J Altern Complement Med. 6: 311-320Jahangiri A. Moghaddam F.R. Najafi S.

Hypertonic dextrose versus corticosteroid local injection for the treatment of osteoarthritis in the first carpometacarpal joint: a double-blind randomized clinical trial.

J Orthop Sci. 19: 737-743Rabago D. Patterson J.J. Mundt M. et al.

Dextrose prolotherapy for knee osteoarthritis: a randomized controlled trial.

Ann Fam Med. 11: 229-237

Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity.

Altern Ther Health Med. 6 (): 68-74Eslamian F. Amouzandeh B.

Therapeutic effects of prolotherapy with intra-articular dextrose injection in patients with moderate knee osteoarthritis: a single-arm study with 6 months follow up.

Ther Adv Musculoskelet Dis. 7: 35-44

Therapeutic injection of dextrose: Prolotherapy, perineural injection therapy and hydrodissection.

PM&R Knowledge Now. Pishgahi A. Abolhasan R. Shakouri S.K. et al.

Effect of dextrose prolotherapy, platelet rich plasma and autologous conditioned serum on knee osteoarthritis: a randomized clinical trial.

Iranian J Allergy Asthma Immunol. https://doi.org/10.18502/ijaai.v19i3.3452Rezasoltani Z. Azizi S. Najafi S. et al.

Physical therapy, intra-articular dextrose prolotherapy, botulinum neurotoxin, and hyaluronic acid for knee osteoarthritis: randomized clinical trial.

Int J Rehabil Res. 43: 219-227Arias-Vázquez P.I. Tovilla-Zárate C.A. Legorreta-Ramírez B.G. et al.

Prolotherapy for knee osteoarthritis using hypertonic dextrose vs other interventional treatments: systematic review of clinical trials.

Adv Rheumatol. 59: 39Yelland M.J. Glasziou P.P. Bogduk N. et al.

Prolotherapy injections, saline injections, and exercises for chronic low-back pain: a randomized trial.

Spine. 29: 9-16Dechow E. Davies R.K. Carr A.J. et al.

A randomized, double-blind, placebo-controlled trial of sclerosing injections in patients with chronic low back pain.

Rheumatology. 38: 1255-1259Yelland M. del Mar C. Pirozzo S. et al.

Prolotherapy injections for chronic low-back pain.

in: Yelland M. Cochrane database of systematic reviews. John Wiley & Sons, Ltd, https://doi.org/10.1002/14651858.CD004059.pub2Khan S. Kumar A. Varshney M. et al.

Dextrose prolotherapy for recalcitrant coccygodynia.

J Orthop Surg. 16: 27-29Miller M.R. Mathews R.S. Reeves K.D.

Treatment of painful advanced internal lumbar disc derangement with intradiscal injection of hypertonic dextrose.

Pain Physician. 9: 115-121Cusi M. Saunders J. Hungerford B. et al.

The use of prolotherapy in the sacroiliac joint.

Br J Sports Med. 44: 100-104

Functional outcome from sacroiliac joint prolotherapy in patients with sacroiliac joint instability.

Complement Therapies Med. 37: 64-68

Modified dextrose prolotherapy for recurrent temporomandibular joint dislocation.

Br J Oral Maxillofac Surg. 52: 63-66

Efficacy of prolotherapy and arthrocentesis in management of temporomandibular joint hypermobility.

CRANIO. : 1-9https://doi.org/10.1080/08869634.2020.1861887Priyadarshini S. Gnanam A. Sasikala B. et al.

Evaluation of prolotherapy in comparison with occlusal splints in treating internal derangement of the temporomandibular joint – A randomized controlled trial.

J Cranio-Maxillofacial Surg. 49: 24-28

Long-term effects of dextrose prolotherapy for anterior cruciate ligament laxity.

Altern Ther Health Med. 9: 58-62Hauser R.A. Matias D. Woznica D. et al.

Lumbar instability as an etiology of low back pain and its treatment by prolotherapy: A review.

J Back Musculoskeletal Rehabil. : 1-12https://doi.org/10.3233/BMR-210097

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