The janus face of ketone bodies in hypertension

aCardiovascular Translational Research Center

bDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina

cSchool of Kinesiology, Auburn University, Auburn, Alabama, USA

Correspondence to Cameron G. McCarthy, Department of Cell Biology and Anatomy, Cardiovascular Translational Research Center, University of South Carolina School of Medicine, 6311 Garners Ferry Road, Columbia, SC 29209, USA. Tel: +1 803 216 3915; e-mail: [email protected]

Abbreviations: βOHB, β-hydroxybutyrate; AcAc, acetoacetate; ACAT, acetyl-CoA acetyltransferases; ACAT1, acetyl-CoA acetyltransferase 1; BDH, βOHB-dehydrogenase; CoA, coenzyme A; CPT-1, carnitine palmitoyl transferase; GPCR, G-protein coupled receptor; HMGCL, HMG-CoA lyase; HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA; HMGCS2, 3-hydroxy-3-methylglutaryl-CoA synthase 2; MCTs, medium chain triglycerides; NADH, nicotinamide adenine dinucleotide; OXCT1, 3-oxoacid CoA-transferase 1; SCOT1, succinyl-CoA:3-ketoacid CoA transferase 1

Received 7 June, 2022

Revised 14 June, 2022

Accepted 14 June, 2022

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