aDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai

bTranslational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana

cDepartment of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh

dInstitute of Cardiovascular Diseases, Madras Medical Mission, Chennai, India

Correspondence to Dr Nitish R. Mahapatra, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India. Tel: +91 44 2257 4128; e-mail: [email protected]

Abbreviations: β-gal, beta-galactosidase; BMI, body mass index; cfPWV, carotid-femoral pulse wave velocity; ChIP, chromatin immunoprecipitation; CI, confidence interval; CKD, chronic kidney disease; CVDs, cardiovascular diseases; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; IKK, IκB kinase; LD, linkage disequilibrium; MAF, minor allele frequency; MAP, mean arterial pressure; MD, molecular dynamics; MMP8, matrix metalloproteinase 8; NF-κB, nuclear factor kappa B; OR, odds ratio; PCR, polymerase chain reaction; RFLP, restriction fragment length polymorphism; ROC, receiver operating characteristic; SAS, south Asian superpopulation; SBP, systolic blood pressure; SD, standard deviation; SDM, site-directed mutagenesis; SNP, single nucleotide polymorphism; TNF-α, tumor necrosis factor-alpha; vWF, von Willebrand factor

Received 25 January, 2022

Revised 9 April, 2022

Accepted 27 May, 2022

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