Integrin subunit α -v (ITGAV) has been demonstrated to be dysregulated and involved in cancer promotion processes in a variety of cancers, but studies on nasopharyngeal carcinoma (NPC) have been limited. Our study aimed to comprehensively assess the expression level and potential mechanisms of ITGAV in NPC.

A total of 13 mRNA expression datasets and internal tissue microarrays were included. ITGAV protein and mRNA were overexpressed in NPC. The pathways of upregulated genes positively related to ITGAV in NPC were analyzed, and the PI3K−Akt signaling pathway, cell cycle, and human papillomavirus infections were most significantly enriched. The protein–protein interaction network was constructed for the genes enriched in these pathways, and the corresponding hub genes were obtained. Among them, breast cancer susceptibility gene 1 (BRCA1) was predicted to be a transcription factor of ITGAV via the Cistrome DB Toolkit, which was also confirmed by ChIP-seq information and correlation calculations.

ITGAV is overexpressed in NPC and can regulate BRCA1 to participate in the cancer process. ITGAV serves as a potential therapeutic target in NPC patients.

How to cite: Huang S-W, Luo J-Y, Qin L-T, et al. Upregulation of ITGAV and the underlying mechanisms in nasopharyngeal carcinoma. Electron J Biotechnol 2022;60. https://doi.org/10.1016/j.ejbt.2022.09.002.

BRCA1

Breast cancer

Cancer

Cell cycle

Gene chip

Integrin

ITGAV

Nasopharyngeal carcinoma immunohistochemistry

Therapeutic target

Transcription factors

Breast cancer susceptibility gene 1

Differentially expressed genes

Gene Expression Omnibus

Immunoreactivity score

Integrin subunit α-V

Kyoto Encyclopedia of Genes and Genomes

Nasopharyngeal carcinoma

National Center for Biotechnology Information

Protein-protein interaction

Receiver operating characteristic

Standard mean deviation

Summary receiver operating characteristic

The Cancer Genome Atlas

© 2022 Pontificia Universidad Católica de Valparaíso. Production and hosting by Elsevier B.V.