Audia JP, Yang X-M, Crockett ES, Housley N, UlHaq E, O’Donnell K, Cohen MV, Downey JM, Alvarez DF (2018) Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function. Basic Res Cardiol 113:32. https://doi.org/10.1007/s00395-018-0692-z

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bell RM, Basalay M, Bøtker HE, Kalkhoran SB, Carr RD, Cunningham J, Davidson SM, England TJ, Giesz S, Ghosh AK, Golforoush P, Gourine AV, Hausenloy DJ, Heusch G, Ibanez B, Kleinbongard P, Lecour S, Lukhna K, Ntsekhe M, Ovize M, Salama AD, Vilahur G, Walker JM, Yellon DM (2022) Remote ischaemic conditioning: defining critical criteria for success-report from the 11th hatter cardiovascular workshop. Basic Res Cardiol 117:39. https://doi.org/10.1007/s00395-022-00947-2

CAS  Article  PubMed  PubMed Central  Google Scholar 

Birnbaum Y, Ye R, Ye Y (2021) Aspirin blocks the infarct-size limiting effect of ischemic postconditioning in the rat. Cardiovasc Drugs Ther. https://doi.org/10.1007/s10557-021-07241-8

Article  PubMed  PubMed Central  Google Scholar 

Carrick D, Haig C, Rauhalammi S, Ahmed N, Mordi I, McEntegart M, Petrie MC, Eteiba H, Lindsay M, Watkins S, Hood S, Davie A, Mahrous A, Sattar N, Welsh P, Tzemos N, Radjenovic A, Ford I, Oldroyd KG, Berry C (2015) Pathophysiology of LV remodeling in survivors of STEMI: inflammation, remote myocardium, and prognosis. JACC Cardiovasc Imaging 8:779–789. https://doi.org/10.1016/j.jcmg.2015.03.007

Article  PubMed  PubMed Central  Google Scholar 

Cung T-T, Morel O, Cayla G, Rioufol G, Garcia-Dorado D, Angoulvant D, Bonnefoy-Cudraz E, Guérin P, Elbaz M, Delarche N, Coste P, Vanzetto G, Metge M, Aupetit J-F, Jouve B, Motreff P, Tron C, Labeque J-N, Steg PG, Cottin Y, Range G, Clerc J, Claeys MJ, Coussement P, Prunier F, Moulin F, Roth O, Belle L, Dubois P, Barragan P, Gilard M, Piot C, Colin P, De Poli F, Morice M-C, Ider O, Dubois-Randé J-L, Unterseeh T, Le Breton H, Béard T, Blanchard D, Grollier G, Malquarti V, Staat P, Sudre A, Elmer E, Hansson MJ, Bergerot C, Boussaha I, Jossan C, Derumeaux G, Mewton N, Ovize M (2015) Cyclosporine before PCI in patients with acute myocardial infarction. N Engl J Med 373:1021–1031. https://doi.org/10.1056/NEJMoa1505489

CAS  Article  PubMed  Google Scholar 

Engstrøm T, Kelbæk H, Helqvist S, Høfsten DE, Kløvgaard L, Clemmensen P, Holmvang L, Jørgensen E, Pedersen F, Saunamaki K, Ravkilde J, Tilsted H-H, Villadsen A, Aarøe J, Jensen SE, Raungaard B, Bøtker HE, Terkelsen CJ, Maeng M, Kaltoft A, Krusell LR, Jensen LO, Veien KT, Kofoed KF, Torp-Pedersen C, Kyhl K, Nepper-Christensen L, Treiman M, Vejlstrup N, Ahtarovski K, Lønborg J, Køber L (2017) Effect of ischemic postconditioning during primary percutaneous coronary intervention for patients with ST-segment elevation myocardial infarction: a randomized clinical trial. JAMA Cardiol 2:490–497. https://doi.org/10.1001/jamacardio.2017.0022

Article  PubMed  PubMed Central  Google Scholar 

Gaspar A, Lourenço AP, Pereira MA, Azevedo P, Roncon-Albuquerque R Jr, Marques J, Leite-Moreira AF (2018) Randomized controlled trial of remote ischaemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI). Basic Res Cardiol 113:14. https://doi.org/10.1007/s00395-018-0672-3

Article  PubMed  Google Scholar 

Hausenloy DJ, Kharbanda RK, Møller UK, Ramlall M, Aarøe J, Butler R, Bulluck H, Clayton T, Dana A, Dodd M, Engstrom T, Evans R, Lassen JF, Christensen EF, Garcia-Ruiz JM, Gorog DA, Hjort J, Houghton RF, Ibanez B, Knight R, Lippert FK, Lønborg JT, Maeng M, Milasinovic D, More R, Nicholas JM, Jensen LO, Perkins A, Radovanovic N, Rakhit RD, Ravkilde J, Ryding AD, Schmidt MR, Riddervold IS, Sørensen HT, Stankovic G, Varma M, Webb I, Terkelsen CJ, Greenwood JP, Yellon DM, Bøtker HE (2019) Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial. Lancet 394:1415–1424. https://doi.org/10.1016/S0140-6736(19)32039-2

Article  PubMed  PubMed Central  Google Scholar 

Ikonomidis I, Vlastos D, Andreadou I, Gazouli M, Efentakis P, Varoudi M, Makavos G, Kapelouzou A, Lekakis J, Parissis J, Katsanos S, Tsilivarakis D, Hausenloy DJ, Alexopoulos D, Cokkinos DV, Bøtker H-E, Iliodromitis EK (2021) Vascular conditioning prevents adverse left ventricular remodelling after acute myocardial infarction: a randomised remote conditioning study. Basic Res Cardiol 116:9. https://doi.org/10.1007/s00395-021-00851-1

CAS  Article  PubMed  Google Scholar 

Kleinbongard P, Andreadou I, Vilahur G (2021) The platelet paradox of injury versus protection in myocardial infarction-has it been overlooked? Basic Res Cardiol 116:37. https://doi.org/10.1007/s00395-021-00876-6

Article  PubMed  PubMed Central  Google Scholar 

Kleinbongard P, Heusch G (2022) A fresh look at coronary microembolization. Nat Rev Cardiol 19:265–280. https://doi.org/10.1038/s41569-021-00632-2

Article  PubMed  Google Scholar 

Lieder HR, Tsoumani M, Andreadou I, Schrör K, Heusch G, Kleinbongard P (2022) Platelet-mediated transfer of cardioprotection by remote ischemic conditioning and Its abrogation by aspirin but not by ticagrelor. Cardiovasc Drugs Ther. https://doi.org/10.1007/s10557-022-07345-9

Article  PubMed  Google Scholar 

Mishra PK, Adameova A, Hill JA, Baines CP, Kang PM, Downey JM, Narula J, Takahashi M, Abbate A, Piristine HC, Kar S, Su S, Higa JK, Kawasaki NK, Matsui T (2019) Guidelines for evaluating myocardial cell death. Am J Physiol Heart Circ Physiol 317:H891–H922. https://doi.org/10.1152/ajpheart.00259.2019

CAS  Article  PubMed  PubMed Central  Google Scholar 

Sloth AD, Schmidt MR, Munk K, Kharbanda RK, Redington AN, Schmidt M, Pedersen L, Sørensen HT, Bøtker HE (2014) Improved long-term clinical outcomes in patients with ST-elevation myocardial infarction undergoing remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention. Eur Heart J 35:168–175. https://doi.org/10.1093/eurheartj/eht369

Article  PubMed  Google Scholar 

Yang X-M, Cui L, Alhammouri A, Downey JM, Cohen MV (2013) Triple therapy greatly increases myocardial salvage during ischemia/reperfusion in the in situ rat heart. Cardiovasc Drugs Ther 27:403–412. https://doi.org/10.1007/s10557-6474-9

CAS  Article  PubMed  Google Scholar 

Yang X-M, Liu Y, Cui L, Yang X, Liu Y, Tandon N, Kambayashi J, Downey JM, Cohen MV (2013) Platelet P2Y12 blockers confer direct postconditioning-like protection in reperfused rabbit hearts. J Cardiovasc Pharm Ther 18:251–262. https://doi.org/10.1177/1074248412467692

CAS  Article  Google Scholar