Targeting hepatic sulfane sulfur/hydrogen sulfide signaling pathway with α-lipoic acid to prevent diabetes-induced liver injury via upregulating hepatic CSE/3-MST expression

Adeyemi DO, Ukwenya VO, Obuotor EM, Adewole SO. Anti-hepatotoxic activities of Hibiscus sabdariffa L. in animal model of streptozotocin diabetes-induced liver damage. BMC Complement Altern Med. 2014;14:277.

PubMed  PubMed Central  Article  Google Scholar 

Targher G, Bertolini L, Padovani R, Rodella S, Zoppini G, Pichiri I, Sorgato C, Zenari L, Bonora E. Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type 1 diabetes. J Hepatol. 2010;53(4):713–8.

CAS  PubMed  Article  Google Scholar 

Leite NC, Villela-Nogueira CA, Pannain VL, Bottino AC, Rezende GF, Cardoso CR, Salles GF. Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors. Liver Int. 2011;31(5):700–6.

PubMed  Article  Google Scholar 

Mandal A, Bhattarai B, Kafle P, Khalid M, Jonnadula SK, Lamicchane J, Kanth R, Gayam V. Elevated liver enzymes in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease. Cureus. 2018;10(11):e3626.

PubMed  PubMed Central  Google Scholar 

Chen X, Wen HQ, Li QL, Shen LS, Luo XW, Zhou B, Guo RM. Quantification of liver fat deposition in obese and diabetic patients: a pilot study on the correlation with myocardium and periapical fat content. Liver Res. 2022;6(2):103–10.

CAS  Article  Google Scholar 

Musso G, Gambino R, Cassader M, Pagano G. Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann Med. 2011;43(8):617–49.

PubMed  Article  Google Scholar 

Yasui K, Hashimoto E, Komorizono Y, Koike K, Arii S, Imai Y, Shima T, Kanbara Y, Saibara T, Mori T, Kawata S, Uto H, Takami S, Sumida Y, Takamura T, Kawanaka M, Okanoue T, Japan NASH Study Group, Ministry of Health Labour and Welfare of Japan. Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2011;9(5):428–33.

PubMed  Article  Google Scholar 

Zang S, Wang L, Ma X, Zhu G, Zhuang Z, Xun Y, Zhao F, Yang W, Liu J, Luo Y, Liu Y, Ye D, Shi J. Neutrophils play a crucial role in the early stage of nonalcoholic steatohepatitis via neutrophil elastase in Mice. Cell Biochem Biophys. 2015;73(2):479–87.

CAS  PubMed  Article  Google Scholar 

Moreno-Fernandez ME, Giles DA, Stankiewicz TE, Sheridan R, Karns R, Cappelletti M, Lampe K, Mukherjee R, Sina C, Sallese A, Bridges JP, Hogan SP, Aronow BJ, Hoebe K, Divanovic S. Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. JCI Insight. 2018;3(6):e93626.

PubMed Central  Article  Google Scholar 

Zheng F, Cai Y. Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet. Lipids Health Dis. 2019;18(1):6.

PubMed  PubMed Central  Article  Google Scholar 

Fealy CE, Haus JM, Solomon TP, Pagadala M, Flask CA, McCullough AJ, Kirwan JP. Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver disease. J Appl Physiol. 2012;113(1):1–6.

CAS  PubMed  PubMed Central  Article  Google Scholar 

González-Rodríguez A, Mayoral R, Agra N, Valdecantos MP, Pardo V, Miquilena-Colina ME, Vargas-Castrillón J, Lo Iacono O, Corazzari M, Fimia GM, Piacentini M, Muntané J, Boscá L, García-Monzón C, Martín-Sanz P, Valverde ÁM. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 2014;5(4):e1179.

PubMed  PubMed Central  Article  Google Scholar 

Nasiri-Ansari N, Nikolopoulou C, Papoutsi K, Kyrou I, Mantzoros CS, Kyriakopoulos G, Chatzigeorgiou A, Kalotychou V, Randeva MS, Chatha K, Kontzoglou K, Kaltsas G, Papavassiliou AG, Randeva HS, Kassi E. Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in high fat diet fed ApoE(-/-) Mice by activating autophagy and reducing ER stress and apoptosis. Int J Mol Sci. 2021;22(2):818.

CAS  PubMed Central  Article  Google Scholar 

Athyros VG, Tziomalos K, Gossios TD, Griva T, Anagnostis P, Kargiotis K, Pagourelias ED, Theocharidou E, Karagiannis A, Mikhailidis DP, GREACE Study Collaborative Group. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis. Lancet. 2010;376(9756):1916–22.

CAS  PubMed  Article  Google Scholar 

Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ, American Gastroenterological Association; American Association for the Study of Liver Diseases; American College of Gastroenterology. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the study of liver diseases, and American College of Gastroenterology. Gastroenterology. 2012;142(7):1592–609.

PubMed  Article  Google Scholar 

Sato K, Gosho M, Yamamoto T, Kobayashi Y, Ishii N, Ohashi T, Nakade Y, Ito K, Fukuzawa Y, Yoneda M. Vitamin E has a beneficial effect on nonalcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Nutrition. 2015;31(7–8):923–30.

CAS  PubMed  Article  Google Scholar 

Padmalayam I, Hasham S, Saxena U, Pillarisetti S. Lipoic acid synthase (LASY): a novel role in inflammation, mitochondrial function and insulin resistance. Diabetes. 2000;58:600–8.

Article  Google Scholar 

Szelag M, Mikulski D, Molski M. Quantum-chemical investigation of the structure and the antioxidant properties of α-lipoic acid and its metabolites. J Mol Model. 2012;18:2907–16.

CAS  PubMed  Article  Google Scholar 

Basu PP, Shah J, Aloysius M, Aloysius M, Jnr Brown RS. Effect of Vitamin E and alpha lipoic acid in nonalcoholic fatty liver disease: a randomized, placebo-controlled, open-label, prospective clinical trial (VAIN Trial). Open J Gastroenterol. 2014;4(5):199–207.

Article  Google Scholar 

Agathos E, Tentolouris A, Eleftheriadou I, Katsaouni P, Nemtzas I, Petrou A, Papanikolaou C, Tentolouris N. Effect of α-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy. J Int Med Res. 2018;46(5):1779–90.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Dugbartey GJ, Alornyo KK, N’guessan BB, Atule S, Mensah SD, Adjei S. Supplementation of conventional anti-diabetic therapy with alpha-lipoic acid prevents early development and progression of diabetic nephropathy. Biomed Pharmacother. 2022;149:112818.

CAS  PubMed  Article  Google Scholar 

Dugbartey GJ, Wonje QL, Alornyo KK, Robertson L, Adams I, Boima V, Mensah SD. Combination therapy of alpha-lipoic acid, gliclazide and ramipril protects against development of diabetic cardiomyopathy via inhibition of TGF-β/Smad pathway. Front Pharmacol. 2022;13:850542.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med. 1998;24(6):1023–39.

CAS  PubMed  Article  Google Scholar 

Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009;1790(10):1149–60.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bast A, Haenen GR. Lipoic acid: a multifunctional antioxidant. BioFactors. 2003;17:207–13.

CAS  PubMed  Article  Google Scholar 

Bilska A, Dudek M, Iciek M, Kwiecień I, Sokołowska-Jezewicz M, Filipek B, Włodek L. Biological actions of lipoic acid associated with sulfane sulfur metabolism. Pharmacol Rep. 2008;60(2):225–32.

CAS  PubMed  Google Scholar 

Bilska-Wilkosz A, Iciek M, Kowalczyk-Pachel D, Górny M, Sokołowska-Jeżewicz M, Włodek L. Lipoic acid as a possible pharmacological source of hydroge sulfide/sulfane sulfur. Molecules. 2017;22(3):388.

PubMed Central  Article  Google Scholar 

Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 1996;16:1066–71.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Blackstone E, Morrison M, Roth MB. H2S induces a suspended animation-like state in mice. Science. 2005;308(5721):518.

CAS  PubMed  Article  Google Scholar 

Panagaki T, Randi EB, Szabo C. Role of hydrogen sulfide and 3-mercaptopyruvate sulfurtransferase in the regulation of the endoplasmic reticulum stress response in hepatocytes. Biomolecules. 2020;10(12):1692.

CAS  PubMed Central  Article  Google Scholar 

Werge MP, McCann A, Galsgaard ED, Holst D, Bugge A, Albrechtsen NJW, Gluud LL. The role of the transsulfuration pathway in non-alcoholic fatty liver disease. J Clin Med. 2021;10(5):1081.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Li L, Whiteman M, Guan YY, Neo KL, Cheng Y, Lee SW, Zhao Y, Baskar R, Tan CH, Moore PK. Characterization of a novel water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insight into the biology of hydrogen sulfide. Circulation. 2008;117:2351–60.

CAS  PubMed  Article  Google Scholar 

Juriasingani S, Jackson A, Zhang MY, Ruthirakanthan A, Dugbartey GJ, Sogutdelen E, Levine M, Mandurah M, Whiteman M, Luke P, Sener A. Evaluating the effects of subnormothermic perfusion with AP39 in a novel blood-free model of ex vivo kidney preservation and reperfusion. Int J Mol Sci. 2021;22:7180.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhang MY, Dugbartey GJ, Juriasingani S, Akbari M, Liu W, Haig A, McLeod P, Arp J, Sener A. Sodium thiosulfate-supplemented UW solution protects renal grafts against prolonged cold ischemia-reperfusion injury in a murine model of syngeneic kidney transplantation. Biomed Pharmacother. 2022;145:112435.

PubMed  Article  Google Scholar 

Dugbartey GJ. Diabetic nephropathy: a potential savior with “rotten-eg

留言 (0)

沒有登入
gif