FSCN1 induced PTPRF-dependent tumor microenvironment inflammatory reprogramming promotes lung adenocarcinoma progression via regulating macrophagic glycolysis

H. Sung, J. Ferlay, R.L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal et al., Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209–249 (2021)

Article  Google Scholar 

R.S. Herbst, D. Morgensztern, C. Boshoff, The biology and management of non-small cell lung cancer. Nature 553, 446–454 (2018)

Article  CAS  Google Scholar 

I. Hwang, J.W. Kim, K. Ylaya, E.J. Chung, H. Kitano, C. Perry et al., Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients. J. Transl. Med. 18, 443 (2020)

Article  CAS  Google Scholar 

X. Dai, L. Lu, S. Deng, J. Meng, C. Wan, J. Huang et al., USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer. Theranostics 10, 9332–9347 (2020)

Article  CAS  Google Scholar 

Y. Pan, Y. Yu, X. Wang, T. Zhang, Tumor-Associated Macrophages in Tumor Immunity. Front. Immunol. 11, 583084 (2020)

Article  CAS  Google Scholar 

S.L. Wood, M. Pernemalm, P.A. Crosbie, A.D. Whetton, The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets. Cancer Treat. Rev. 40, 558–566 (2014)

Article  CAS  Google Scholar 

I. Rhee, Diverse macrophages polarization in tumor microenvironment. Arch. Pharm. Res. 39, 1588–1596 (2016)

Article  CAS  Google Scholar 

M. Najafi, N. Hashemi Goradel, B. Farhood, E. Salehi, M.S. Nashtaei, N. Khanlarkhani et al., Macrophage polarity in cancer: A review. J. Cell. Biochem. 120, 2756–2765 (2019)

Article  CAS  Google Scholar 

S. Wang, R. Liu, Q. Yu, L. Dong, Y. Bi, G. Liu, Metabolic reprogramming of macrophages during infections and cancer. Cancer Lett. 452, 14–22 (2019)

Article  CAS  Google Scholar 

Y. Chen, T. Tian, Z.Y. Li, C.Y. Wang, R. Deng, W.Y. Deng et al., FSCN1 is an effective marker of poor prognosis and a potential therapeutic target in human tongue squamous cell carcinoma. Cell Death Dis. 10, 356 (2019)

Article  CAS  Google Scholar 

T. Chiyomaru, H. Enokida, S. Tatarano, K. Kawahara, Y. Uchida, K. Nishiyama et al., miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer. Br. J. Cancer 102, 883–891 (2010)

Article  CAS  Google Scholar 

I. Gupta, S. Vranic, H. Al-Thawadi, A.E. Al Moustafa, Fascin in gynecological cancers: An update of the literature. Cancers (Basel). 13, 5760 (2021)

Article  CAS  Google Scholar 

M. Kano, N. Seki, N. Kikkawa, L. Fujimura, I. Hoshino, Y. Akutsu et al., miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma. Int. J. Cancer 127, 2804–2814 (2010)

Article  CAS  Google Scholar 

J. Liang, Z. Liu, X. Wei, L. Zhou, Y. Tang, C. Zhou et al., Expression of FSCN1 and FOXM1 are associated with poor prognosis of adrenocortical carcinoma patients. BMC Cancer 19, 1165 (2019)

Article  CAS  Google Scholar 

S.J. Kim, D.C. Kim, M.C. Kim, G.J. Jung, K.H. Kim, J.S. Jang et al., Fascin expression is related to poor survival in gastric cancer. Pathol. Int. 62, 777–784 (2012)

Article  CAS  Google Scholar 

C.-Q. Wang, C.-H. Tang, Y. Wang, L. Jin, Q. Wang, X. Li et al., FSCN1 gene polymorphisms: biomarkers for the development and progression of breast cancer. Sci. Rep. 7, 15887 (2017)

Article  CAS  Google Scholar 

M. Zhang, Z. Zhao, X. Duan, P. Chen, Z. Peng, H. Qiu, FSCN1 predicts survival and is regulated by a PI3K-dependent mechanism in renal cell carcinoma. J. Cell Physiol. 233, 4748–4758 (2018)

Article  CAS  Google Scholar 

D. Soulieres, F.R. Hirsch, F.A. Shepherd, W. Bordogna, P. Delmar, D.S. Shames et al., PTPRF expression as a potential prognostic/predictive marker for treatment with erlotinib in non-small-cell lung cancer. J. Thorac. Oncol. 10, 1364–1369 (2015)

Article  CAS  Google Scholar 

W.W. Du, L. Fang, M. Li, X. Yang, Y. Liang, C. Peng et al., MicroRNA miR-24 enhances tumor invasion and metastasis by targeting PTPN9 and PTPRF to promote EGF signaling. J. Cell Sci. 126, 1440–1453 (2013)

PubMed  CAS  Google Scholar 

O.R. Colegio, N.Q. Chu, A.L. Szabo, T. Chu, A.M. Rhebergen, V. Jairam et al., Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 513, 559–563 (2014)

Article  CAS  Google Scholar 

R. Dziadziuszko, D.R. Camidge, F.R. Hirsch, The insulin-like growth factor pathway in lung cancer. J. Thorac. Oncol. 3, 815–818 (2008)

Article  Google Scholar 

J.M. Pitt, A. Marabelle, A. Eggermont, J.C. Soria, G. Kroemer, L. Zitvogel, Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy. Ann. Oncol. 27, 1482–1492 (2016)

Article  CAS  Google Scholar 

P.J. Murray, Macrophage Polarization. Annu. Rev. Physiol. 79, 541–566 (2017)

Article  CAS  Google Scholar 

I. Vitale, G. Manic, L.M. Coussens, G. Kroemer, L. Galluzzi, Macrophages and Metabolism in the Tumor Microenvironment. Cell Metab. 30, 36–50 (2019)

Article  CAS  Google Scholar 

M. Wenes, M. Shang, M. Di Matteo, J. Goveia, R. Martin-Perez, J. Serneels et al., Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis. Cell Metab. 24, 701–715 (2016)

Article  CAS  Google Scholar 

D.G. DeNardo, B. Ruffell, Macrophages as regulators of tumour immunity and immunotherapy. Nat. Rev. Immunol. 19, 369–382 (2019)

Article  CAS  Google Scholar 

A. Schmall, H.M. Al-Tamari, S. Herold, M. Kampschulte, A. Weigert, A. Wietelmann et al., Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer. Am. J. Respir. Crit. Care Med. 191, 437–447 (2015)

Article  CAS  Google Scholar 

S. Saha, I.N. Shalova, S.K. Biswas, Metabolic regulation of macrophage phenotype and function. Immunol. Rev. 280, 102–111 (2017)

Article  CAS  Google Scholar 

L. Zhu, Q. Zhao, T. Yang, W. Ding, Y. Zhao, Cellular metabolism and macrophage functional polarization. Int. Rev. Immunol. 34, 82–100 (2015)

Article  CAS  Google Scholar 

K. Mehla, P.K. Singh, Metabolic regulation of macrophage polarization in cancer. Trends Cancer 5, 822–834 (2019)

Article  CAS  Google Scholar 

G.M. Tannahill, A.M. Curtis, J. Adamik, E.M. Palsson-McDermott, A.F. McGettrick, G. Goel et al., Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature 496, 238–242 (2013)

Article  CAS  Google Scholar 

Y. Wang, A. Shan, Z. Zhou, W. Li, L. Xie, B. Du et al., LncRNA TCONS_00004099-derived microRNA regulates oncogenesis through PTPRF in gliomas. Ann. Transl. Med. 9, 1023 (2021)

Article  CAS  Google Scholar 

R. Bera, C.Y. Chiou, M.C. Yu, J.M. Peng, C.R. He, C.Y. Hsu et al., Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis. Hepatology 59, 2238–2250 (2014)

Article  CAS  Google Scholar 

T.E. Whitmore, A. Peterson, T. Holzman, A. Eastham, L. Amon, M. McIntosh et al., Integrative analysis of N-linked human glycoproteomic data sets reveals PTPRF ectodomain as a novel plasma biomarker candidate for prostate cancer. J. Proteome Res. 11, 2653–2665 (2012)

Article  CAS  Google Scholar 

T. Gan, A.T. Stevens, X. Xiong, Y.A. Wen, T.N. Farmer, A.T. Li et al., Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer. Oncogene 39, 6789–6801 (2020)

Article  CAS  Google Scholar 

M. Scrima, C. De Marco, F. De Vita, F. Fabiani, R. Franco, G. Pirozzi et al., The nonreceptor-type tyrosine phosphatase PTPN13 is a tumor suppressor gene in non-small cell lung cancer. Am. J. Pathol. 180, 1202–1214 (2012)

Article  CAS  Google Scholar 

P. Ji, Y. Gong, M.-L. Jin, H.-L. Wu, L.-W. Guo, Y.-C. Pei et al., In vivo multidimensional CRISPR screens identify as an immunotherapy target in triple-negative breast cancer. Sci Adv 8, eab18247 (2022)

Article  CAS  Google Scholar 

R. Kang, M. Gamdzyk, Y. Luo, H. Tang, L. Huang, C. Lenahan et al., Three days delayed recanalization improved neurological function in pMCAO Rats by increasing M2 microglia-possible involvement of the IL-4R/STAT6/PPARγ pathway. Transl. Stroke Res. (2022)

C.N. Kosti, P.C. Vaitsi, A.G. Pappas, M.P. Iliopoulou, K.K. Psarra, S.F. Magkouta et al., CSF1/CSF1R signaling mediates malignant pleural effusion formation. JCI Insight. 7(6), e155300 (2022)

留言 (0)

沒有登入
gif