Memtsoudis SG, Cozowicz C, Bekeris J, et al. Anaesthetic care of patients undergoing primary hip and knee arthroplasty: consensus recommendations from the International Consensus on Anaesthesia-Related Outcomes after Surgery group (ICAROS) based on a systematic review and meta-analysis. Br J Anaesth 2019; 123: 269–87. https://doi.org/10.1016/j.bja.2019.05.042

Article  PubMed  PubMed Central  Google Scholar 

Memtsoudis SG, Sun X, Chiu YL, et al. Perioperative comparative effectiveness of anesthetic technique in orthopedic patients. Anesthesiology 2013; 118: 1046–58. https://doi.org/10.1097/aln.0b013e318286061d

Article  PubMed  Google Scholar 

Shin HJ, Do SH, Lee JS, Kim TK, Na HS. Comparison of intraoperative sedation with dexmedetomidine versus propofol on acute postoperative pain in total knee arthroplasty under spinal anesthesia: a randomized trial. Anesth Analg 2019; 129: 1512–8. https://doi.org/10.1213/ane.0000000000003315

Article  PubMed  Google Scholar 

Chan IA, Maslany JG, Gorman KJ, O'Brien JM, McKay WP. Dexmedetomidine during total knee arthroplasty performed under spinal anesthesia decreases opioid use: a randomized-controlled trial. Can J Anesth 2016; 63: 569–76. https://doi.org/10.1007/s12630-016-0597-y

Article  PubMed  Google Scholar 

Lee C, Lee J, Lee G, Lee H, Koh E, Hwang J. Pregabalin and dexmedetomidine combined for pain after total knee arthroplasty or total hip arthroplasty performed under spinal anesthesia. Orthopedics 2018; 41: 365–70. https://doi.org/10.3928/01477447-20181023-04

Article  PubMed  Google Scholar 

Mei B, Meng G, Xu G, et al. Intraoperative sedation with dexmedetomidine is superior to propofol for elderly patients undergoing hip arthroplasty: a prospective randomized controlled study. Clin J Pain 2018; 34: 811–7. https://doi.org/10.1097/ajp.0000000000000605

Article  PubMed  Google Scholar 

Sin JC, Tabah A, Campher MJ, Laupland KB, Eley VA. The effect of dexmedetomidine on postanesthesia care unit discharge and recovery: a systematic review and meta-analysis. Anesth Analg 2022; 134: 1229–44. https://doi.org/10.1213/ane.0000000000005843

CAS  Article  PubMed  Google Scholar 

Weerink MA, Struys M, Hannivoort LN, Barends CR, Absalom AR, Colin P. Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine. Clin Pharmacokinet 2017; 56: 893–913. https://doi.org/10.1007/s40262-017-0507-7

CAS  Article  PubMed  PubMed Central  Google Scholar 

POISE Study Group, Devereaux PJ, Yang H, et al. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet 2008; 371: 1839–47. https://doi.org/10.1016/s0140-6736(08)60601-7

Article  Google Scholar 

Roshanov PS, Rochwerg B, Patel A, et al. Withholding versus continuing angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers before noncardiac surgery: an analysis of the vascular events in noncardiac surgery patients cohort evaluation prospective cohort. Anesthesiology 2017; 126: 16–27. https://doi.org/10.1097/aln.0000000000001404

CAS  Article  PubMed  Google Scholar 

von Elm E, Altman DG, Egger M, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007; 370: 1453–7. https://doi.org/10.1016/s0140-6736(07)61602-x

Article  Google Scholar 

Collins GS, Reitsma JB, Altman DG, Moons KG. Transparent reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): the TRIPOD statement. J Clin Epidemiol 2015; 68: 134–43. https://doi.org/10.1016/j.jclinepi.2014.11.010

Article  PubMed  Google Scholar 

McHugh ML. Interrater reliability: the kappa statistic. Biochem Med (Zagreb) 2012; 22: 276–82.

Article  Google Scholar 

White IR, Daniel R, Royston P. Avoiding bias due to perfect prediction in multiple imputation of incomplete categorical variables. Comput Stat Data Anal 2010; 54: 2267–75. https://doi.org/10.1016/j.csda.2010.04.005

Article  PubMed  PubMed Central  Google Scholar 

Landerman LR, Land KC, Pieper CF. An empirical evaluation of the predictive mean matching method for imputing missing values. Sociol Methods Res 1997; 26: 3–33.

Article  Google Scholar 

Royston P, Moons KG, Altman DG, Vergouwe Y. Prognosis and prognostic research: developing a prognostic model. BMJ 2009; 338: b604. https://doi.org/10.1136/bmj.b604

Article  PubMed  Google Scholar 

Ko KH, Jun IJ, Lee S, Lim Y, Yoo B, Kim KM. Effective dose of dexmedetomidine to induce adequate sedation in elderly patients under spinal anesthesia. Korean J Anesthesiol 2015; 68: 575–80. https://doi.org/10.4097/kjae.2015.68.6.575

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bland JM, Altman DG. Statistics notes: bootstrap resampling methods. BMJ 2015; 350: h2622. https://doi.org/10.1136/bmj.h2622

Article  PubMed  Google Scholar 

Harrell FE Jr. Regression Modeling Strategies: With Applications to Linear Models, Logistic and Ordinal Regression, and Survival Analysis, 2nd ed. New York: Springer; 2015.

Book  Google Scholar 

Leung L, Lee LH, Lee B, Chau A, Wang EH. The safety of high-dose dexmedetomidine after cardiac surgery: a historical cohort study. Can J Anesth 2022; 69: 323–32. https://doi.org/10.1007/s12630-021-02167-z

CAS  Article  PubMed  Google Scholar 

Giovannitti JA Jr, Thoms SM, Crawford JJ. Alpha-2 adrenergic receptor agonists: a review of current clinical applications. Anesth Prog 2015; 62: 31–9. https://doi.org/10.2344/0003-3006-62.1.31

Article  PubMed  PubMed Central  Google Scholar 

Herndon CL, Levitsky MM, Ezuma C, Sarpong NO, Shah RP, Cooper HJ. Lower dosing of bupivacaine spinal anesthesia is not associated with improved perioperative outcomes after total joint arthroplasty. Arthroplast Today 2021; 11: 6–9. https://doi.org/10.1016/j.artd.2021.05.020

Article  PubMed  PubMed Central  Google Scholar 

American College of Surgeons Committee on Trauma. Advanced Trauma Life Support (Student Manual). Chicago: American College of Surgeons; 2018.

Google Scholar 

Reddy SV, Balaji D, Ahmed SN. Dexmedetomidine versus esmolol to attenuate the hemodynamic response to laryngoscopy and tracheal intubation: a randomized double-blind clinical study. Int J Appl Basic Med Res 2014; 4: 95–100. https://doi.org/10.4103/2229-516x.136788

Article  PubMed  PubMed Central  Google Scholar 

Beloeil H, Garot M, Lebuffe G, et al. Balanced opioid-free anesthesia with dexmedetomidine versus balanced anesthesia with remifentanil for major or intermediate noncardiac surgery. Anesthesiology 2021; 134: 541–51. https://doi.org/10.1097/aln.0000000000003725

CAS  Article  PubMed  Google Scholar 

Jones GM, Murphy CV, Gerlach AT, Goodman EM, Pell LJ. High-dose dexmedetomidine for sedation in the intensive care unit: an evaluation of clinical efficacy and safety. Ann Pharmacother 2011; 45: 740–7. https://doi.org/10.1345/aph.1p726

CAS  Article  PubMed  Google Scholar 

Demiri M, Antunes T, Fletcher D, Martinez V. Perioperative adverse events attributed to α2-adrenoceptor agonists in patients not at risk of cardiovascular events: systematic review and meta-analysis. Br J Anaesth 2019; 123: 795–807. https://doi.org/10.1016/j.bja.2019.07.029

CAS  Article  PubMed  Google Scholar 

Fu Q, Ogoh S. Sex differences in baroreflex function in health and disease. J Physiol Sci 2019; 69: 851–9. https://doi.org/10.1007/s12576-019-00727-z

CAS  Article  PubMed  Google Scholar 

Gillis EE, Sullivan JC. Sex Differences in hypertension: recent advances. Hypertension 2016; 68: 1322–7. https://doi.org/10.1161/hypertensionaha.116.06602

CAS  Article  PubMed  Google Scholar 

Zonneveld TP, Richard E, Vergouwen MD, et al. Blood pressure-lowering treatment for preventing recurrent stroke, major vascular events, and dementia in patients with a history of stroke or transient ischaemic attack. Cochrane Database Syst Rev 2018; 7: CD007858. https://doi.org/10.1002/14651858.cd007858.pub2

Article  PubMed  Google Scholar 

Choi YF, Wong TW, Lau CC. Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubation. Emerg Med J 2004; 21: 700–2. https://doi.org/10.1136/emj.2002.004143

CAS  Article  PubMed  PubMed Central  Google Scholar 

Guritzky RP, Arain SR, Ebert TJ. Mechanism of hypotension from midazolam: direct vascular versus indirect effects in humans. Available from URL: http://www.asaabstracts.com/strands/asaabstracts/abstract.htm?year=2001&index=3&absnum=1808 (accessed June 2022).

Kaye AD, Urman RD, Cornett EM, et al. Enhanced recovery pathways in orthopedic surgery. J Anaesthesiol Clin Pharmacol 2019; 35: S35–9. https://doi.org/10.4103/joacp.joacp_35_18

Article  PubMed  PubMed Central  Google Scholar 

Babyak MA. What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Psychosom Med 2004; 66: 411–21. https://doi.org/10.1097/01.psy.0000127692.23278.a9

Article  PubMed  Google Scholar 

Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996; 49: 1373–9. https://doi.org/10.1016/s0895-4356(96)00236-3

CAS  Article  PubMed  Google Scholar 

Meng L, Yu W, Wang T, Zhang L, Heerdt PM, Gelb AW. Blood pressure targets in perioperative care. Hypertension 2018; 72: 806–17. https://doi.org/10.1161/hypertensionaha.118.11688

CAS  Article  PubMed  Google Scholar 

Bijker JB, van Klei WA, Kappen TH, van Wolfswinkel L, Moons KG, Kalkman CJ. Incidence of intraoperative hypotension as a function of the chosen definition: literature definitions applied to a retrospective cohort using automated data collection. Anesthesiology 2007; 107: 213–20. https://doi.org/10.1097/01.anes.0000270724.40897.8e

Article  PubMed  Google Scholar 

Tsimihodimos V, Gonzalez-Villalpando C, Meigs JB, Ferrannini E. Hypertension and diabetes mellitus: coprediction and time trajectories. Hypertension 2018; 71: 422–8. https://doi.org/10.1161/hypertensionaha.117.10546

CAS  Article  PubMed  Google Scholar