Abel T, Zukin RS (2008) Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr Opin Pharmacol 8:57–64. https://doi.org/10.1016/j.coph.2007.12.002

CAS  Article  PubMed  PubMed Central  Google Scholar 

Adams JM, Cory S (1975) Modified nucleosides and bizarre 5’-termini in mouse myeloma mRNA. Nature 255:28–33. https://doi.org/10.1038/255028a0

CAS  Article  PubMed  Google Scholar 

Alarcon CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF (2015) N6-methyladenosine marks primary microRNAs for processing. Nature 519:482–485. https://doi.org/10.1038/nature14281

CAS  Article  PubMed  PubMed Central  Google Scholar 

Al-Mahdawi S, Pinto RM, Ismail O, Varshney D, Lymperi S, Sandi C, Trabzuni D, Pook M (2008) The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues. Hum Mol Genet 17:735–746. https://doi.org/10.1093/hmg/ddm346

CAS  Article  PubMed  Google Scholar 

Alunni A, Bally-Cuif L (2016) A comparative view of regenerative neurogenesis in vertebrates. Development 143:741–753. https://doi.org/10.1242/dev.122796

CAS  Article  PubMed  PubMed Central  Google Scholar 

Arney KL, Fisher AG (2004) Epigenetic aspects of differentiation. J Cell Sci 117:4355–4363. https://doi.org/10.1242/jcs.01390

CAS  Article  PubMed  Google Scholar 

Audia JE, Campbell RM (2016) Histone modifications and cancer. Cold Spring Harb Perspect Biol 8(4):a019521. https://doi.org/10.1101/cshperspect.a019521

Article  PubMed  PubMed Central  Google Scholar 

Aumiller V, Forstemann K (2008) Roles of microRNAs beyond development–metabolism and neural plasticity. Biochim Biophys Acta 1779:692–696. https://doi.org/10.1016/j.bbagrm.2008.04.008

CAS  Article  PubMed  Google Scholar 

Bannister AJ, Kouzarides T (2011) Regulation of chromatin by histone modifications. Cell Res 21(3):381–395. https://doi.org/10.1038/cr.2011.22

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bennett SA, Tanaz R, Cobos SN, Torrente MP (2019) Epigenetics in amyotrophic lateral sclerosis: a role for histone post-translational modifications in neurodegenerative disease. Transl Res 204:19–30. https://doi.org/10.1016/j.trsl.2018.10.002

CAS  Article  PubMed  Google Scholar 

Berger SL (2002) Histone modifications in transcriptional regulation. Curr Opin Genet Dev 12:142–148. https://doi.org/10.1016/s0959-437x(02)00279-4

CAS  Article  PubMed  Google Scholar 

Berson A, Nativio R, Berger SL, Bonini NM (2018) Epigenetic regulation in neurodegenerative diseases. Trends Neurosci 41:587–598. https://doi.org/10.1016/j.tins.2018.05.005

CAS  Article  PubMed  PubMed Central  Google Scholar 

Berson A, Sartoris A, Nativio R, Van Deerlin V, Toledo JB, Porta S, Liu S, Chung CY, Garcia BA, Lee VM, Trojanowski JQ, Johnson FB, Berger SL, Bonini NM (2017) TDP-43 promotes neurodegeneration by impairing chromatin remodeling. Curr Biol 27:3579–3590. https://doi.org/10.1016/j.cub.2017.10.024

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bestor TH (2000) The DNA methyltransferases of mammals. Hum Mol Genet 9:2395–2402. https://doi.org/10.1093/hmg/9.16.2395

CAS  Article  PubMed  Google Scholar 

Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16:6–21. https://doi.org/10.1101/gad.947102

CAS  Article  PubMed  Google Scholar 

Bochtler M, Kolano A, Xu GL (2017) DNA demethylation pathways: additional players and regulators. BioEssays 39:1–13. https://doi.org/10.1002/bies.201600178

CAS  Article  PubMed  Google Scholar 

Bodi Z, Button JD, Grierson D, Fray RG (2010) Yeast targets for mRNA methylation. Nucleic Acids Res 38:5327–5335. https://doi.org/10.1093/nar/gkq266

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bourinaris T, Houlden H (2018) C9orf72 and its relevance in parkinsonism and movement disorders: a comprehensive review of the literature. Mov Disord Clin Pract 5:575–585. https://doi.org/10.1002/mdc3.12677

Article  PubMed  PubMed Central  Google Scholar 

Brenner C, Fuks F (2006) DNA methyltransferases: facts, clues, mysteries. Curr Top Microbiol Immunol 301:45–66. https://doi.org/10.1007/3-540-31390-7_3

CAS  Article  PubMed  Google Scholar 

Bronisz A, Carey HA, Godlewski J, Sif S, Ostrowski MC, Sharma SM (2014) The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF). J Biol Chem 289:326–334. https://doi.org/10.1074/jbc.M113.493874

CAS  Article  PubMed  Google Scholar 

Canaani D, Kahana C, Lavi S, Groner Y (1979) Identification and mapping of N6-methyladenosine containing sequences in simian virus 40 RNA. Nucleic Acids Res 6:2879–2899. https://doi.org/10.1093/nar/6.8.2879

CAS  Article  PubMed  PubMed Central  Google Scholar 

Carey HA, Bronisz A, Cabrera J, Hildreth BR, Cuitino M, Fu Q, Ahmad A, Toribio RE, Ostrowski MC, Sharma SM (2016) Failure to target RANKL signaling through p38-MAPK results in defective osteoclastogenesis in the microphthalmia cloudy-eyed mutant. J Cell Physiol 231:630–640. https://doi.org/10.1002/jcp.25108

CAS  Article  PubMed  PubMed Central  Google Scholar 

Carissimi C, Fulci V, Macino G (2009) MicroRNAs: novel regulators of immunity. Autoimmun Rev 8:520–524. https://doi.org/10.1016/j.autrev.2009.01.008

CAS  Article  PubMed  Google Scholar 

Che XQ, Zhao QH, Huang Y, Li X, Ren RJ, Chen SD, Guo QH, Wang G (2018) Mutation screening of the CHCHD2 gene for Alzheimer’s disease and frontotemporal dementia in Chinese Mainland population. J Alzheimers Dis 61:1283–1288. https://doi.org/10.3233/JAD-170692

CAS  Article  PubMed  Google Scholar 

Chen CC, Wang KY, Shen CK (2012) The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases. J Biol Chem 287:33116–33121. https://doi.org/10.1074/jbc.C112.406975

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chen X, Yu C, Guo M, Zheng X, Ali S, Huang H, Zhang L, Wang S, Huang Y, Qie S, Wang J (2019) Down-regulation of m6A mRNA methylation is involved in dopaminergic neuronal death. Acs Chem Neurosci 10:2355–2363. https://doi.org/10.1021/acschemneuro.8b00657

CAS  Article  PubMed  Google Scholar 

Cheng X (1995) Structure and function of DNA methyltransferases. Annu Rev Biophys Biomol Struct 24:293–318. https://doi.org/10.1146/annurev.bb.24.060195.001453

CAS  Article  PubMed  Google Scholar 

Chen-Kiang S, Nevins JR, Darnell JJ (1979) N-6-methyl-adenosine in adenovirus type 2 nuclear RNA is conserved in the formation of messenger RNA. J Mol Biol 135:733–752. https://doi.org/10.1016/0022-2836(79)90174-8

CAS  Article  PubMed  Google Scholar 

Chestnut BA, Chang Q, Price A, Lesuisse C, Wong M, Martin LJ (2011) Epigenetic regulation of motor neuron cell death through DNA methylation. J Neurosci 31:16619–16636. https://doi.org/10.1523/JNEUROSCI.1639-11.2011

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chou CC, Zhang Y, Umoh ME, Vaughan SW, Lorenzini I, Liu F, Sayegh M, Donlin-Asp PG, Chen YH, Duong DM, Seyfried NT, Powers MA, Kukar T, Hales CM, Gearing M, Cairns NJ, Boylan KB, Dickson DW, Rademakers R, Zhang YJ, Petrucelli L, Sattler R, Zarnescu DC, Glass JD, Rossoll W (2018) TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Nat Neurosci 21:228–239. https://doi.org/10.1038/s41593-017-0047-3

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chuang DM, Leng Y, Marinova Z, Kim HJ, Chiu CT (2009) Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci 32:591–601. https://doi.org/10.1016/j.tins.2009.06.002

CAS  Article  PubMed  PubMed Central  Google Scholar 

Cobos SN, Bennett SA, Torrente MP (2019) The impact of histone post-translational modifications in neurodegenerative diseases. Biochim Biophys Acta Mol Basis Dis 1865:1982–1991. https://doi.org/10.1016/j.bbadis.2018.10.019

CAS  Article  PubMed  Google Scholar 

Coppede F (2014) The potential of epigenetic therapies in neurodegenerative diseases. Front Genet 5:220. https://doi.org/10.3389/fgene.2014.00220

CAS  Article  PubMed  PubMed Central  Google Scholar 

Cudkowicz ME, Andres PL, Macdonald SA, Bedlack RS, Choudry R, Brown RJ, Zhang H, Schoenfeld DA, Shefner J, Matson S, Matson WR, Ferrante RJ (2009) Phase 2 study of sodium phenylbutyrate in ALS. Amyotroph Lateral Scler 10(2):99–106. https://doi.org/10.1080/17482960802320487

CAS  Article  PubMed  Google Scholar 

de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370:737–749.