Probiotics and the Treatment of Parkinson's Disease: An Update

Alipour Nosrani E, Tamtaji OR, Alibolandi Z, Sarkar P, Ghazanfari M, Azami Tameh A, Taghizadeh M, Banikazemi Z, Hadavi R, Naderi Taheri M (2020) Neuroprotective effects of probiotics bacteria on animal model of Parkinson’s disease induced by 6-hydroxydopamine: A behavioral, biochemical, and histological study. J Immunoassay Immunochem 42:106–120

PubMed  Article  Google Scholar 

Asl ZR, Sepehri G, Salami M (2019) Probiotic treatment improves the impaired spatial cognitive performance and restores synaptic plasticity in an animal model of Alzheimer’s disease. Behav Brain Res 376:112183

Article  Google Scholar 

Azad M, Kalam A, Sarker M, Li T, Yin J (2018) Probiotic species in the modulation of gut microbiota: an overview. BioMed Res Int. https://doi.org/10.1155/2018/9478630

Article  PubMed  PubMed Central  Google Scholar 

Bagheri S, Heydari A, Alinaghipour A, Salami M (2019) Effect of probiotic supplementation on seizure activity and cognitive performance in PTZ-induced chemical kindling. Epilepsy Behav 95:43–50

PubMed  Article  Google Scholar 

Barichella M, Pacchetti C, Bolliri C, Cassani E, Iorio L, Pusani C, Pinelli G, Privitera G, Cesari I, Faierman SA (2016) Probiotics and prebiotic fiber for constipation associated with Parkinson disease: an RCT. Neurology 87(12):1274–1280

CAS  PubMed  Article  Google Scholar 

Bessler H, Djaldetti R, Salman H, Bergman M, Djaldetti M (1999) IL-1β, IL-2, IL-6 and TNF-α production by peripheral blood mononuclear cells from patients with Parkinson’s disease. Biomed Pharmacother 53(3):141–145

CAS  PubMed  Article  Google Scholar 

Block ML, Zecca L, Hong J-S (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8(1):57–69

CAS  PubMed  Article  Google Scholar 

Borre YE, O’Keeffe GW, Clarke G, Stanton C, Dinan TG, Cryan JF (2014) Microbiota and neurodevelopmental windows: implications for brain disorders. Trends Mol Med 20(9):509–518

PubMed  Article  Google Scholar 

Borzabadi S, Oryan S, Eidi A, Aghadavod E, Kakhaki RD, Tamtaji OR, Taghizadeh M, Asemi Z (2018) The effects of probiotic supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinsonâ s disease: a randomized, double-blind, placebo-controlled trial. Arch Iran Med 21(7):289–295

PubMed  Google Scholar 

Cassani E, Privitera G, Pezzoli G, Pusani C, Madio C, Iorio L, Barichella M (2011) Use of probiotics for the treatment of constipation in Parkinson’s disease patients. Minerva Gastroenterol Dietol 57(2):117–121

CAS  PubMed  Google Scholar 

Castelli V, d’Angelo M, Lombardi F, Alfonsetti M, Antonosante A, Catanesi M, Benedetti E, Palumbo P, Cifone MG, Giordano A (2020) Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson’s disease models. Aging (Albany, NY) 12(5):4641

CAS  Article  Google Scholar 

Chen Y, Hou Y, Yang J, Du R, Chen C, Chen F, Wang H, Ge R, Chen J (2018) P75 involved in the ubiquitination of α-synuclein in rotenone-based Parkinson’s disease models. Neuroscience 388:367–373

CAS  PubMed  Article  Google Scholar 

Daliri EBM, Lee BH, Oh DH (2019) Safety of probiotics in health and disease. In: Singh RB, Watson RR, Takahashi T (eds) The role of functional food security in global health. Academic Press, Cambridge, pp 603–622

Google Scholar 

Distrutti E, O’Reilly JA, McDonald C, Cipriani S, Renga B, Lynch MA, Fiorucci S (2014) Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP. PLoS ONE 9(9):e106503. https://doi.org/10.1371/journal.pone.0106503

CAS  Article  PubMed  PubMed Central  Google Scholar 

Dong L, Lu F, Zu J, Zhang W, Xu C, Jin G, Yang X, Xiao Q, Cui C, Xu R (2020) MiR-133b inhibits MPP+-induced apoptosis in Parkinson’s disease model by inhibiting the ERK1/2 signaling pathway. Eur Rev Med Pharmacol Sci 24(21):11192–11198

PubMed  Google Scholar 

Doron S, Snydman DR (2015) Risk and safety of probiotics. Clin Infect Dis 60(Suppl 2):129–134. https://doi.org/10.1093/cid/civ085

Article  Google Scholar 

Dwyer Z, Chaiquin M, Landrigan J, Ayoub K, Shail P, Rocha J, Childers CL, Storey KB, Philpott DJ, Sun H (2021) The impact of dextran sodium sulphate and probiotic pre-treatment in a murine model of Parkinson’s disease. J Neuroinflammation 18(1):1–15

Article  Google Scholar 

Forssten S, Ouwehand AC (2020) Dose-response recovery of probiotic strains in simulated gastro-intestinal passage. Microorganisms. https://doi.org/10.3390/microorganisms8010112

Article  PubMed  PubMed Central  Google Scholar 

Georgescu D, Ancusa OE, Georgescu LA, Ionita I, Reisz D (2016) Nonmotor gastrointestinal disorders in older patients with Parkinson’s disease: is there hope? Clin Interv Aging 11:1601

CAS  PubMed  PubMed Central  Article  Google Scholar 

Guo S, Al-Sadi R, Said HM, Ma TY (2013) Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14. Am J Pathol 182(2):375–387

CAS  PubMed  PubMed Central  Article  Google Scholar 

Hannan MA, Dash R, Sohag AAM, Haque M, Moon IS (2020) Neuroprotection against oxidative stress: phytochemicals targeting TrkB signaling and the Nrf2-ARE antioxidant system. Front Mol Neurosci 13:116

PubMed  PubMed Central  Article  Google Scholar 

Hashimoto M, Hsu LJ, Xia Y, Takeda A, Sisk A, Sundsmo M, Masliah E (1999) Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro. NeuroReport 10(4):717–721

CAS  PubMed  Article  Google Scholar 

Hassanzadeh K, Rahimmi A (2018) Oxidative stress and neuroinflammation in the story of Parkinson’s disease: could targeting these pathways write a good ending? J Cell Physiol 234(1):23–32. https://doi.org/10.1002/jcp.26865

CAS  Article  PubMed  Google Scholar 

Hosseinifard E-S, Morshedi M, Bavafa-Valenlia K, Saghafi-Asl M (2019) The novel insight into anti-inflammatory and anxiolytic effects of psychobiotics in diabetic rats: possible link between gut microbiota and brain regions. Eur J Nutr 58(8):3361–3375

CAS  PubMed  Article  Google Scholar 

Howells D, Porritt MJ, Wong J, Batchelor P, Kalnins R, Hughes A, Donnan G (2000) Reduced BDNF mRNA expression in the Parkinson’s disease substantia nigra. Exp Neurol 166(1):127–135

CAS  PubMed  Article  Google Scholar 

Hsieh T-H, Kuo C-W, Hsieh K-H, Shieh M-J, Peng C-W, Chen Y-C, Chang Y-L, Huang Y-Z, Chen C-C, Chang P-K (2020) Probiotics alleviate the progressive deterioration of motor functions in a mouse model of Parkinson’s disease. Brain Sci 10(4):206

CAS  PubMed Central  Article  Google Scholar 

Ibrahim A, Ali RAR, Manaf MRA, Ahmad N, Tajurruddin FW, Qin WZ, Desa SHM, Ibrahim NM (2020) Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease: A randomised controlled trial. PLoS ONE 15(12):e0244680

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ishii T, Furuoka H, Kaya M, Kuhara T (2021) Oral Administration of probiotic bifidobacterium breve improves facilitation of hippocampal memory extinction via restoration of aberrant higher induction of neuropsin in an MPTP-induced mouse model of Parkinson’s disease. Biomedicines 9(2):167

CAS  PubMed  PubMed Central  Article  Google Scholar 

Jankovic J (2008) Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79(4):368–376

CAS  PubMed  Article  Google Scholar 

Jankovic J, Stacy M (2007) Medical management of levodopa-associated motor complications in patients with Parkinson’s disease. CNS Drugs 21(8):677–692

CAS  PubMed  Article  Google Scholar 

Jiménez-Pranteda ML, Pérez-Davó A, Monteoliva-Sánchez M, Ramos-Cormenzana A, Aguilera M (2015) Food omics validation: towards understanding key features for gut microbiota, probiotics and human health. Food Anal Methods 8(2):272–289

Article  Google Scholar 

Jin W (2020) Regulation of BDNF-TrkB signaling and potential therapeutic strategies for Parkinson’s disease. J Clin Med 9(1):257

CAS  PubMed Central  Article  Google Scholar 

Kim YS, Joh TH (2006) Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson’s disease. Exp Mol Med 38(4):333–347

CAS  PubMed  Article  Google Scholar 

Kim GH, Kim JE, Rhie SJ, Yoon S (2015) The role of oxidative stress in neurodegenerative diseases. Experimental Neurobiology 24(4):325

PubMed  PubMed Central  Article  Google Scholar 

Kouchaki E, Kakhaki RD, Tamtaji OR, Dadgostar E, Behnam M, Zaribaf A, Nikoueinejad H, Akbari H, Asemi Z (2018) Correlation of serum levels and gene expression of tumor necrosis factor-α-induced protein-8 like-2 with Parkinson disease severity. Metab Brain Dis 33(6):1955–1959

CAS  PubMed  Article  Google Scholar 

Kraemer BR, Snow JP, Vollbrecht P, Pathak A, Valentine WM, Deutch AY, Carter BD (2014) A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress. J Biol Chem 289(31):21205–21216

PubMed  PubMed Central  Article  Google Scholar 

Lavasani S, Dzhambazov B, Nouri M, Fåk F, Buske S, Molin G, Thorlacius H, Alenfall J, Jeppsson B, Weström B (2010) A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells. PLoS ONE 5(2):9009

Article  Google Scholar 

Lee Y-J, Cho H-N, Soh J-W, Jhon GJ, Cho C-K, Chung H-Y, Bae S, Lee S-J, Lee Y-S (2003) Oxidative stress-induced apoptosis is mediated by ERK1/2 phosphorylation. Exp Cell Res 291(1):251–266

CAS  PubMed 

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