Jang JY, Blum A, Liu J, Finkel T (2018) The role of mitochondria in aging. J Clin Investig 128(9):3662–3670. https://doi.org/10.1172/jci120842
Article PubMed PubMed Central Google Scholar
Kirkwood TB (2005) Understanding the odd science of aging. Cell 120(4):437–447. https://doi.org/10.1016/j.cell.2005.01.027
CAS Article PubMed Google Scholar
Kirkland JL, Tchkonia T (2017) Cellular senescence: a translational perspective. EBioMedicine 21:21–28. https://doi.org/10.1016/j.ebiom.2017.04.013
Article PubMed PubMed Central Google Scholar
Pignolo RJ, Passos JF, Khosla S, Tchkonia T, Kirkland JL (2020) Reducing senescent cell burden in aging and disease. Trends Mol Med 26(7):630–638. https://doi.org/10.1016/j.molmed.2020.03.005
CAS Article PubMed PubMed Central Google Scholar
Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, Fearnside J, Tatoud R, Blanc V, Lindon JC, Mitchell SC, Holmes E, McCarthy MI, Scott J, Gauguier D, Nicholson JK (2006) Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci USA 103(33):12511–12516. https://doi.org/10.1073/pnas.0601056103
CAS Article PubMed PubMed Central Google Scholar
Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, Hu C, Wong FS, Szot GL, Bluestone JA, Gordon JI, Chervonsky AV (2008) Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature 455(7216):1109–1113. https://doi.org/10.1038/nature07336
CAS Article PubMed PubMed Central Google Scholar
Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 101(44):15718–15723. https://doi.org/10.1073/pnas.0407076101
CAS Article PubMed PubMed Central Google Scholar
Sergeev IN, Aljutaily T, Walton G, Huarte E (2020) Effects of synbiotic supplement on human gut microbiota, body composition and weight loss in obesity. Nutrients 12:1. https://doi.org/10.3390/nu12010222
Quigley EMM (2017) Microbiota-brain-gut axis and neurodegenerative diseases. Curr Neurol Neurosci Rep 17(12):94. https://doi.org/10.1007/s11910-017-0802-6
CAS Article PubMed Google Scholar
Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet MF, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK (2016) Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell 167(6):1469-1480.e1412. https://doi.org/10.1016/j.cell.2016.11.018
CAS Article PubMed PubMed Central Google Scholar
Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T, Xie Z, Chu X, Yang J, Wang H, Chang S, Gong Y, Ruan L, Zhang G, Yan S, Lian W, Du C, Yang D, Zhang Q, Lin F, Liu J, Zhang H, Ge C, Xiao S, Ding J, Geng M (2019) Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression. Cell Res 29(10):787–803. https://doi.org/10.1038/s41422-019-0216-x
CAS Article PubMed PubMed Central Google Scholar
Chen K, Zheng X, Feng M, Li D, Zhang H (2017) Gut microbiota-dependent metabolite trimethylamine N-oxide contributes to cardiac dysfunction in western diet-induced obese mice. Front Physiol 8:139. https://doi.org/10.3389/fphys.2017.00139
Article PubMed PubMed Central Google Scholar
Rohrmann S, Linseisen J, Allenspach M, von Eckardstein A, Müller D (2016) plasma concentrations of trimethylamine-N-oxide are directly associated with dairy food consumption and low-grade inflammation in a german adult population. J Nutr 146(2):283–289. https://doi.org/10.3945/jn.115.220103
CAS Article PubMed Google Scholar
Pascal MC, Burini JF, Chippaux M (1984) Regulation of the trimethylamine N-oxide (TMAO) reductase in escherichia coli: analysis of tor::mud1 operon fusion. Mol Gen Genet MGG 195(1–2):351–355. https://doi.org/10.1007/bf00332770
CAS Article PubMed Google Scholar
Craciun S, Marks JA, Balskus EP (2014) Characterization of choline trimethylamine-lyase expands the chemistry of glycyl radical enzymes. ACS Chem Biol 9(7):1408–1413. https://doi.org/10.1021/cb500113p
CAS Article PubMed Google Scholar
Zhu Y, Jameson E, Crosatti M, Schäfer H, Rajakumar K, Bugg TD, Chen Y (2014) Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. Proc Natl Acad Sci USA 111(11):4268–4273. https://doi.org/10.1073/pnas.1316569111
CAS Article PubMed PubMed Central Google Scholar
Andreesen JR (1994) Glycine metabolism in anaerobes. Antonie Van Leeuwenhoek 66(1–3):223–237. https://doi.org/10.1007/bf00871641
CAS Article PubMed Google Scholar
Ke Y, Li D, Zhao M, Liu C, Liu J, Zeng A, Shi X, Cheng S, Pan B, Zheng L, Hong H (2018) Gut flora-dependent metabolite trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress. Free Radical Biol Med 116:88–100. https://doi.org/10.1016/j.freeradbiomed.2018.01.007
Flood JF, Morley JE (1998) Learning and memory in the SAMP8 mouse. Neurosci Biobehav Rev 22(1):1–20. https://doi.org/10.1016/s0149-7634(96)00063-2
CAS Article PubMed Google Scholar
Brunt VE, Gioscia-Ryan RA, Casso AG, VanDongen NS, Ziemba BP, Sapinsley ZJ, Richey JJ, Zigler MC, Neilson AP, Davy KP, Seals DR (2020) Trimethylamine-N-oxide promotes age-related vascular oxidative stress and endothelial dysfunction in mice and healthy humans. Hypertension 76(1):101–112. https://doi.org/10.1161/hypertensionaha.120.14759
CAS Article PubMed Google Scholar
Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A (2019) Cellular senescence: aging, cancer, and injury. Physiol Rev 99(2):1047–1078. https://doi.org/10.1152/physrev.00020.2018
CAS Article PubMed Google Scholar
Hernandez-Segura A, Nehme J, Demaria M (2018) Hallmarks of cellular senescence. Trends Cell Biol 28(6):436–453. https://doi.org/10.1016/j.tcb.2018.02.001
CAS Article PubMed Google Scholar
Casella G, Tsitsipatis D, Abdelmohsen K, Gorospe M (2019) mRNA methylation in cell senescence. Wiley Interdiscip Rev RNA 10(6):e1547. https://doi.org/10.1002/wrna.1547
Article PubMed PubMed Central Google Scholar
He S, Sharpless NE (2017) Senescence in health and disease. Cell 169(6):1000–1011. https://doi.org/10.1016/j.cell.2017.05.015
CAS Article PubMed PubMed Central Google Scholar
Adams PD (2009) Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell 36(1):2–14. https://doi.org/10.1016/j.molcel.2009.09.021
CAS Article PubMed Google Scholar
Bernadotte A, Mikhelson VM, Spivak IM (2016) Markers of cellular senescence telomere shortening as a marker of cellular senescence. Aging 8(1):3–11
Rezzani R, Nardo L, Favero G, Peroni M, Rodella LF (2014) Thymus and aging: morphological, radiological, and functional overview. Age (Dordr) 36(1):313–351. https://doi.org/10.1007/s11357-013-9564-5
Childs BG, Durik M, Baker DJ, van Deursen JM (2015) Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat Med 21(12):1424–1435. https://doi.org/10.1038/nm.4000
CAS Article PubMed PubMed Central Google Scholar
Salminen A, Kauppinen A, Kaarniranta K (2012) Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal 24(4):835–845. https://doi.org/10.1016/j.cellsig.2011.12.006
CAS Article PubMed Google Scholar
Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6(12):2853–2868. https://doi.org/10.1371/journal.pbio.0060301
CAS Article PubMed Google Scholar
Basisty N, Kale A, Jeon OH, Kuehnemann C, Payne T, Rao C, Holtz A, Shah S, Sharma V, Ferrucci L, Campisi J, Schilling B (2020) A proteomic atlas of senescence-associated secretomes for aging biomarker development. PLoS Biol 18(1):e3000599. https://doi.org/10.1371/journal.pbio.3000599
CAS Article PubMed PubMed Central Google Scholar
Wiley CD, Liu S, Limbad C, Zawadzka AM, Beck J, Demaria M, Artwood R, Alimirah F, Lopez-Dominguez JA, Kuehnemann C, Danielson SR, Basisty N, Kasler HG, Oron TR, Desprez PY, Mooney SD, Gibson BW, Schilling B, Campisi J, Kapahi P (2019) SILAC analysis reveals increased secretion of hemostasis-related factors by senescent cells. Cell Rep 28(13):3329-3337.e5. https://doi.org/10.1016/j.celrep.2019.08.049
CAS Article PubMed PubMed Central Google Scholar
Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J (2013) p53-Dependent release of alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol 201(4):613–629. https://doi.org/10.1083/jcb.201206006
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