aDepartment of Medical Oncology, Dana-Farber Cancer Institute

bHarvard Medical School, Boston, Massachusetts

cBreast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

dDivision of Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS, Milan, Italy

eDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

Correspondence to Dario Trapani, MD, Department of Medical Oncology, Breast Oncology, Dana-Farber Cancer Institute, Brookline Avenue 450, 02215, Boston, MA 02215, USA. E-mail: [email protected]