Mitofusin-2 mediates cannabidiol-induced neuroprotection against cerebral ischemia in rats

Hankey GJ. Stroke. Lancet. 2017;389:641–54.

PubMed  Article  Google Scholar 

Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, et al. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. 2018;134:293–301.

CAS  PubMed  Article  Google Scholar 

Campbell BCV, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM, et al. Ischaemic stroke. Nat Rev Dis Prim. 2019;5:70.

PubMed  Article  Google Scholar 

Larrea D, Pera M, Gonnelli A, Quintana-Cabrera R, Akman HO, Guardia-Laguarta C, et al. MFN2 mutations in Charcot-Marie-Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics. Hum Mol Genet. 2019;28:1782–800.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Martorell-Riera A, Segarra-Mondejar M, Munoz JP, Ginet V, Olloquequi J, Perez-Clausell J, et al. Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death. EMBO J. 2014;33:2388–407.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Munoz JP, Ivanova S, Sanchez-Wandelmer J, Martinez-Cristobal P, Noguera E, Sancho A, et al. Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J. 2013;32:2348–61.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Xin Y, Wu W, Qu J, Wang X, Lei S, Yuan L, et al. Inhibition of Mitofusin-2 promotes cardiac fibroblast activation via the PERK/ATF4 pathway and reactive oxygen species. Oxid Med Cell Longev. 2019;2019:3649808.

PubMed  PubMed Central  Article  Google Scholar 

Rocha AG, Franco A, Krezel AM, Rumsey JM, Alberti JM, Knight WC, et al. MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science. 2018;360:336–41.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Jiang S, Nandy P, Wang W, Ma X, Hsia J, Wang C, et al. Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex. Mol Neurodegener. 2018;13:5.

PubMed  PubMed Central  Article  Google Scholar 

Peng C, Rao W, Zhang L, Wang K, Hui H, Wang L, et al. Mitofusin 2 ameliorates hypoxia-induced apoptosis via mitochondrial function and signaling pathways. Int J Biochem Cell Biol. 2015;69:29–40.

CAS  PubMed  Article  Google Scholar 

Peng C, Rao W, Zhang L, Gao F, Hui H, Wang K, et al. Mitofusin 2 exerts a protective role in ischemia reperfusion injury through increasing autophagy. Cell Physiol Biochem. 2018;46:2311–24.

CAS  PubMed  Article  Google Scholar 

Romer Thomsen K, Thylstrup B, Kenyon EA, Lees R, Baandrup L, Feldstein Ewing SW, et al. Cannabinoids for the treatment of cannabis use disorder: new avenues for reaching and helping youth? Neurosci Biobehav Rev. 2022;132:169–80.

PubMed  Article  Google Scholar 

Liktor-Busa E, Keresztes A, LaVigne J, Streicher JM, Largent-Milnes TM. Analgesic potential of terpenes derived from Cannabis sativa. Pharmacol Rev. 2021;73:98–126.

CAS  PubMed  Article  Google Scholar 

Landucci E, Mazzantini C, Lana D, Davolio PL, Giovannini MG, Pellegrini-Giampietro DE. Neuroprotective effects of cannabidiol but not delta(9)-tetrahydrocannabinol in rat hippocampal slices exposed to oxygen-glucose deprivation: studies with cannabis extracts and selected cannabinoids. Int J Mol Sci. 2021;22:9773.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Osborne AL, Solowij N, Weston-Green K. A systematic review of the effect of cannabidiol on cognitive function: relevance to schizophrenia. Neurosci Biobehav Rev. 2017;72:310–24.

CAS  PubMed  Article  Google Scholar 

Dash R, Ali MC, Jahan I, Munni YA, Mitra S, Hannan MA, et al. Emerging potential of cannabidiol in reversing proteinopathies. Ageing Res Rev. 2021;65:101209.

CAS  PubMed  Article  Google Scholar 

Khodadadi H, Salles EL, Jarrahi A, Costigliola V, Khan MB, Yu JC, et al. Cannabidiol ameliorates cognitive function via regulation of IL-33 and TREM2 upregulation in a murine model of Alzheimer’s disease. J Alzheimers Dis. 2021;80:973–7.

CAS  PubMed  Article  Google Scholar 

de Almeida CMO, Brito MMC, Bosaipo NB, Pimentel AV, Tumas V, Zuardi AW, et al. Cannabidiol for rapid eye movement sleep behavior disorder. Mov Disord. 2021;36:1711–5.

PubMed  Article  Google Scholar 

Khaksar S, Bigdeli M, Samiee A, Shirazi-Zand Z. Antioxidant and anti-apoptotic effects of cannabidiol in model of ischemic stroke in rats. Brain Res Bull. 2022;180:118–30.

CAS  PubMed  Article  Google Scholar 

Sun S, Hu F, Wu J, Zhang S. Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons. Redox Biol. 2017;11:577–85.

CAS  PubMed  Article  Google Scholar 

Meyer E, Bonato JM, Mori MA, Mattos BA, Guimaraes FS, Milani H, et al. Cannabidiol confers neuroprotection in rats in a model of transient global cerebral ischemia: impact of hippocampal synaptic neuroplasticity. Mol Neurobiol. 2021;58:5338–55.

CAS  PubMed  Article  Google Scholar 

Ceprian M, Jimenez-Sanchez L, Vargas C, Barata L, Hind W, Martinez-Orgado J. Cannabidiol reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke. Neuropharmacology. 2017;116:151–9.

CAS  PubMed  Article  Google Scholar 

Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol. 2007;150:613–23.

CAS  Article  Google Scholar 

Morales P, Jagerovic N. Synthetic and natural derivatives of cannabidiol. Adv Exp Med Biol. 2021;1297:11–25.

CAS  PubMed  Article  Google Scholar 

Li M, Xu B, Li X, Li Y, Qiu S, Chen K, et al. Mitofusin 2 confers the suppression of microglial activation by cannabidiol: insights from in vitro and in vivo models. Brain Behav Immun. 2022;104:155–70.

CAS  PubMed  Article  Google Scholar 

Xu B, Xu J, Cai N, Li M, Liu L, Qin Y, et al. Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3beta-mediated oxidative stress and IRE1alpha/TRAF2/JNK pathway. Free Radic Biol Med. 2021;163:281–96.

CAS  PubMed  Article  Google Scholar 

Zhong J, Dong W, Qin Y, Xie J, Xiao J, Xu J, et al. Roflupram exerts neuroprotection via activation of CREB/PGC-1alpha signalling in experimental models of Parkinson’s disease. Br J Pharmacol. 2020;177:2333–50.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhong J, Li M, Xu J, Dong W, Qin Y, Qiu S, et al. Roflupram attenuates alpha-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant alpha-synuclein. Toxicol Appl Pharmacol. 2022;436:115859.

CAS  PubMed  Article  Google Scholar 

El-Hakim Y, Mani KK, Eldouh A, Pandey S, Grimaldo MT, Dabney A, et al. Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats. Biol Sex Differ. 2021;12:14.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Xu B, Wang T, Xiao J, Dong W, Wen HZ, Wang X, et al. FCPR03, a novel phosphodiesterase 4 inhibitor, alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3beta/ beta-catenin signaling pathway. Biochem Pharmacol. 2019;163:234–49.

CAS  PubMed  Article  Google Scholar 

Hind WH, England TJ, O’Sullivan SE. Cannabidiol protects an in vitro model of the blood-brain barrier from oxygen-glucose deprivation via PPARgamma and 5-HT1A receptors. Br J Pharmacol. 2016;173:815–25.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chen J, Yu H, Zhong J, Feng H, Wang H, Cheng Y, et al. The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion. Brain Res Bull. 2018;137:98–106.

CAS  PubMed  Article  Google Scholar 

Gbel J, Engelhardt E, Pelzer P, Sakthivelu V, Jahn HM, Jevtic M, et al. Mitochondria-endoplasmic reticulum contacts in reactive astrocytes promote vascular remodeling. Cell Metab. 2020;31:791–808.

PubMed  PubMed Central  Article  Google Scholar 

Wang XL, Feng ST, Wang ZZ, Yuan YH, Chen NH, Zhang Y. Parkin, an E3 ubiquitin ligase, plays an essential role in mitochondrial quality control in Parkinson’s disease. Cell Mol Neurobiol. 2021;41:1395–411.

CAS  PubMed  Article  Google Scholar 

Di Domenico F, Casalena G, Jia J, Sultana R, Barone E, Cai J, et al. Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion. J Neurochem. 2012;121:680–92.

PubMed  PubMed Central  Article  Google Scholar 

Wang H, Du YS, Xu WS, Li CJ, Sun H, Hu KR, et al. Exogenous glutathione exerts a therapeutic effect in ischemic stroke rats by interacting with intrastriatal dopamine. Acta Pharmacol Sin. 2022;43:541–51.

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