Update on Sudden Unexpected Death in Epilepsy

Watila M.M. Balarabe S.A. Ojo O. et al.

Overall and cause-specific premature mortality in epilepsy: a systematic review.

Epilepsy Behav. 87: 213-225Christensen J. Pedersen C.B. Sidenius P. et al.

Long-term mortality in children and young adults with epilepsy--A population-based cohort study.

Epilepsy Res. 114: 81-88Mbizvo G.K. Bennett K. Simpson C.R. et al.

Epilepsy-related and other causes of mortality in people with epilepsy: A systematic review of systematic reviews.

Epilepsy Res. 157: 106192

Kløvgaard M., Lynge T.H., Tsiropoulos I., et al., Sudden unexpected death in epilepsy in persons younger than 50 years: A retrospective nationwide cohort study in Denmark, Epilepsia, 62 (10), 2021, 2405-2415.

Thurman D.J. Logroscino G. Beghi E. et al.

The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy.

Epilepsia. 58: 17-26DeGiorgio C.M. Curtis A. Carapetian A. et al.

Why are epilepsy mortality rates rising in the United States? A population-based multiple cause-of-death study.

BMJ Open. 10: e035767Devinsky O. Spruill T. Thurman D. et al.

Recognizing and preventing epilepsy-related mortality: a call for action.

Neurology. 86: 779-786Neligan A. Bell G.S. Johnson A.L. et al.

The long-term risk of premature mortality in people with epilepsy.

Brain. 134: 388-395Fazel S. Wolf A. Långström N. et al.

Premature mortality in epilepsy and the role of psychiatric comorbidity: a total population study.

Lancet. 382: 1646-1654Kløvgaard M. Lynge T.H. Tsiropoulos I. et al.

Epilepsy-related mortality in children and young adults in denmark: a nationwide cohort study.

Neurology. 98: e213-e224Karlovich E. Devinsky O. Brandsoy M. et al.

SUDEP among young adults in the San Diego County Medical Examiner Office.

Epilepsia. 61: e17-e22Kløvgaard M. Lynge T.H. Tsiropoulos I. et al.

Comparing Seizure-Related Death and Suicide in Younger Adults with Epilepsy.

Ann Neurol. 90: 983-987

Deaths in epilepsy.

Med Rec. 77: 58-62Nashef L. So E.L. Ryvlin P. et al.

Unifying the definitions of sudden unexpected death in epilepsy.

Epilepsia. 53: 227-233Holst A.G. Winkel B.G. Risgaard B. et al.

Epilepsy and risk of death and sudden unexpected death in the young: a nationwide study.

Epilepsia. 54: 1613-1620Devinsky O. Bundock E. Hesdorffer D. et al.

Resolving ambiguities in SUDEP classification.

Epilepsia. 59: 1220-1233

Organization WH. ICD-11 for Mortality and Morbidity Statistics 2022.

() ()Verducci C. Friedman D. Donner E.J. et al.

SUDEP classification: discordances between forensic investigators and epileptologists.

Epilepsia. 61: e173-e178Keller A.E. Ho J. Whitney R. et al.

Autopsy-reported cause of death in a population-based cohort of sudden unexpected death in epilepsy.

Epilepsia. 62: 472-480

Sudden unexpected death in epilepsy.

Lancet. 378: 2028-2038Ficker D.M. So E.L. Shen W.K. et al.

Population-based study of the incidence of sudden unexplained death in epilepsy.

Neurology. 51: 1270-1274Thurman D.J. Hesdorffer D.C. French J.A.

Sudden unexpected death in epilepsy: assessing the public health burden.

Epilepsia. 55: 1479-1485Langan Y. Nolan N. Hutchinson M.

The incidence of sudden unexpected death in epilepsy (SUDEP) in South Dublin and Wicklow.

Seizure. 7: 355-358Harden C. Tomson T. Gloss D. et al.

Practice guideline summary: sudden unexpected death in epilepsy incidence rates and risk factors: report of the guideline development, dissemination, and implementation subcommittee of the american academy of neurology and the american epilepsy society.

Neurology. 88: 1674-1680Sveinsson O. Andersson T. Carlsson S. et al.

The incidence of SUDEP: a nationwide population-based cohort study.

Neurology. 89: 170-177Einarsdottir A.B. Sveinsson O. Olafsson E.

Sudden unexpected death in epilepsy. A nationwide population-based study.

Epilepsia. 60: 2174-2181Cihan E. Devinsky O. Hesdorffer D.C. et al.

Temporal trends and autopsy findings of SUDEP based on medico-legal investigations in the United States.

Neurology. 95: e867-e877Keller A.E. Whitney R. Li S.A. et al.

Incidence of sudden unexpected death in epilepsy in children is similar to adults.

Neurology. 91: e107-e111Harowitz J. Crandall L. McGuone D. et al.

Seizure-related deaths in children: The expanding spectrum.

Epilepsia. 62: 570-582Thurman D.J. Beghi E. Begley C.E. et al.

Standards for epidemiologic studies and surveillance of epilepsy.

Epilepsia. 52: 2-26Tomson T. Sveinsson O. Carlsson S. et al.

Evolution over time of SUDEP incidence: A nationwide population-based cohort study.

Epilepsia. 59: e120-e124Ryvlin P. So E.L. Gordon C.M. et al.

Long-term surveillance of SUDEP in drug-resistant epilepsy patients treated with VNS therapy.

Epilepsia. 59: 562-572Tomson T. Nashef L. Ryvlin P.

Sudden unexpected death in epilepsy: current knowledge and future directions.

Lancet Neurol. 7: 1021-1031Serdyuk S. Davtyan K. Burd S. et al.

Cardiac arrhythmias and sudden unexpected death in epilepsy: Results of long-term monitoring.

Heart Rhythm. 18: 221-228Liu J. Peedicail J.S. Gaxiola-Valdez I. et al.

Postictal brainstem hypoperfusion and risk factors for sudden unexpected death in epilepsy.

Neurology. 95: e1694-e1705Christiansen S.N. Jacobsen S.B. Andersen J.D. et al.

Differential Methylation in the GSTT1 Regulatory Region in Sudden Unexplained Death and Sudden Unexpected Death in Epilepsy.

Int J Mol Sci. 22: 2790Patodia S. Tachrount M. Somani A. et al.

MRI and pathology correlations in the medulla in sudden unexpected death in epilepsy (SUDEP): a postmortem study.

Neuropathol Appl Neurobiol. 47: 157-170La A. Rm H. Guye M. Kumar R. et al.

Altered brain connectivity in sudden unexpected death in epilepsy (SUDEP) revealed using resting-state fMRI.

Neuroimage Clin. 24: 102060Allen L.A. Vos S.B. Kumar R. et al.

Cerebellar, limbic, and midbrain volume alterations in sudden unexpected death in epilepsy.

Epilepsia. 60: 718-729Vilella L. Lacuey N. Hampson J.P. et al.

Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP).

Neurology. 92: e171-e182Mueller S.G. Nei M. Bateman L.M. et al.

Brainstem network disruption: a pathway to sudden unexplained death in epilepsy?.

Hum Brain Mapp. 39: 4820-4830Myers K.A. Bello-Espinosa L.E. Symonds J.D. et al.

Heart rate variability in epilepsy: a potential biomarker of sudden unexpected death in epilepsy risk.

Epilepsia. 59: 1372-1380Sivathamboo S. Friedman D. Laze J. et al.

Association of short-term heart rate variability and sudden unexpected death in epilepsy.

Neurology. 97: e2357-e2367Somani A. El-Hachami H. Patodia S. et al.

Regional microglial populations in central autonomic brain regions in SUDEP.

Epilepsia. 62: 1318-1328Somani A. Perry C. Patodia S. et al.

Neuropeptide depletion in the amygdala in sudden unexpected death in epilepsy: a postmortem study.

Epilepsia. 61: 310-318Patodia S. Somani A. O'Hare M. et al.

The ventrolateral medulla and medullary raphe in sudden unexpected death in epilepsy.

Brain. 141: 1719-1733Ryvlin P. Nashef L. Lhatoo S.D. et al.

Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study.

Lancet Neurol. 12: 966-977Devinsky O. Hesdorffer D.C. Thurman D.J. et al.

Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention.

Lancet Neurol. 15: 1075-1088Szurhaj W. Leclancher A. Nica A. et al.

Cardiac Autonomic Dysfunction and Risk of Sudden Unexpected Death in Epilepsy.

Neurology. 96: e2619-e2626Devinsky O. Kim A. Friedman D. et al.

Incidence of cardiac fibrosis in SUDEP and control cases.

Neurology. 91: e55-e61van der Lende M. Surges R. Sander J.W. et al.

Cardiac arrhythmias during or after epileptic seizures.

J Neurol Neurosurg Psychiatry. 87: 69-74Schuele S.U. Bermeo A.C. Locatelli E. et al.

Ictal asystole: a benign condition?.

Epilepsia. 49: 168-171Moseley B.D. Ghearing G.R. Benarroch E.E. et al.

Early seizure termination in ictal asystole.

Epilepsy Res. 97: 220-224Schuele S.U. Bermeo A.C. Alexopoulos A.V. et al.

Anoxia-ischemia: a mechanism of seizure termination in ictal asystole.

Epilepsia. 51: 170-173Bank A.M. Dworetzky B.A. Lee J.W.

Sudden unexpected death in epilepsy in a patient with a cardiac pacemaker.

Seizure. 61: 38-40Surges R. Adjei P. Kallis C. et al.

Pathologic cardiac repolarization in pharmacoresistant epilepsy and its potential role in sudden unexpected death in epilepsy: a case-control study.

Epilepsia. 51: 233-242Li M.C.H. O'Brien T.J. Todaro M. et al.

Acquired cardiac channelopathies in epilepsy: Evidence, mechanisms, and clinical significance.

Epilepsia. 60: 1753-1767Chahal C.A.A. Salloum M.N. Alahdab F. et al.

Systematic review of the genetics of sudden unexpected death in epilepsy: potential overlap with sudden cardiac death and arrhythmia-related genes.

J Am Heart Assoc. 9: e012264Hamdy R.M. Elaziz O.H.A. El Attar R.S. et al.

Evaluation of QT dispersion in epileptic patients and its association with SUDEP risk.

Epilepsy Res. 180: 106860Bagnall R.D. Crompton D.E. Semsarian C.

Genetic Basis of Sudden Unexpected Death in Epilepsy.

Front Neurol. 8: 348Goldman A.M. Behr E.R. Semsarian C. et al.

Sudden unexpected death in epilepsy genetics: Molecular diagnostics and prevention.

Epilepsia. 57: 17-25Bagnall R.D. Crompton D.E. Petrovski S. et al.

Exome-based analysis of cardiac arrhythmia, respiratory control, and epilepsy genes in sudden unexpected death in epilepsy.

Ann Neurol. 79: 522-534Bagnall R.D. Crompton D.E. Cutmore C. et al.

Genetic analysis of PHOX2B in sudden unexpected death in epilepsy cases.

Neurology. 83: 1018-1021Goldman A.M. Glasscock E. Yoo J. et al.

Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death.

Sci Translational Med. 1: 2ra6Young C. Shankar R. Palmer J. et al.

Does intellectual disability increase sudden unexpected death in epilepsy (SUDEP) risk?.

Seizure. 25: 112-116Kuchenbuch M. Barcia G. Chemaly N. et al.

KCNT1 epilepsy with migrating focal seizures shows a temporal sequence with poor outcome, high mortality and SUDEP.

Brain. 142: 2996-3008Cooper M.S. McIntosh A. Crompton D.E. et al.

Mortality in Dravet syndrome.

Epilepsy Res. 128: 43-47Bayat A. Kløvgaard M. Johannesen K.M. et al.

Deciphering the premature mortality in PIGA-CDG – An untold story.

Epilepsy Res. 170: 106530Kim Y. Bravo E. Thirnbeck C.K. et al.

Severe peri-ictal respiratory dysfunction is common in Dravet syndrome.

J Clin Invest. 128: 1141-1153Griffin A. Hamling K.R. Hong S. et al.

Preclinical Animal Models for Dravet Syndrome: Seizure Phenotypes, Comorbidities and Drug Screening.

Front Pharmacol. 9: 573Auerbach D.S. Jones J. Clawson B.C. et al.

Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome.

PLoS One. 8: e77843

Dravet syndrome: a sodium channel interneuronopathy.

Curr Opin Physiol. 2: 42-50Han Z. Chen C. Christiansen A. et al.

Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome.

Sci Transl Med. 12: eaaz6100Lhatoo S.D. Faulkner H.J. Dembny K. et al.

An electroclinical case-control study of sudden unexpected death in epilepsy.

Ann Neurol. 68: 787-796Alexandre V. Mercedes B. Valton L. et al.

Risk factors of postictal generalized EEG suppression in generalized convulsive seizures.

Neurology. 85: 1598-1603Kuo J. Zhao W. Li C.S. et al.

Postictal immobility and generalized EEG suppression are associated with the severity of respiratory dysfunction.

Epilepsia. 57: 412-417Tao J.X. Yung I. Lee A. et al.

Tonic phase of a generalized convulsive seizure is an independent predictor of postictal generalized EEG suppression.

Epilepsia. 54: 858-865Sarkis R.A. Thome-Souza S. Poh M.Z. et al.

Autonomic changes following generalized tonic clonic seizures: an analysis of adult and pediatric patients with epilepsy.

Epilepsy Res. 115: 113-118

Postictal generalized EEG suppression and postictal immobility: what do we know?.

Epileptic Disord. 22: 245-251Wagnon J.L. Korn M.J. Parent R. et al.

Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy.

Hum Mol Genet. 24: 506-515

Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models.

Sci Transl Med. 7: 282ra46Aiba I. Wehrens X.H. Noebels J.L.

Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death.

Proc Natl Acad Sci U S A. 113: E4895-E4903Jansen N.A. Schenke M. Voskuyl R.A. et al.

Apnea Associated with Brainstem Seizures in Cacna1a (S218L) Mice Is Caused by Medullary Spreading Depolarization.

J Neurosci. 39: 9633-9644Loonen I.C.M. Jansen N.A. Cain S.M. et al.

Brainstem spreading depolarization and cortical dynamics during fatal seizures in Cacna1a S218L mice.

Brain. 142: 412-425Wenker I.C. Teran F.A. Wengert E.R. et al.

Postictal death is associated with tonic phase apnea in a mouse model of sudden unexpected death in epilepsy.

Ann Neurol. 89: 1023-1035Lhatoo S.D. Nei M. Raghavan M. et al.

Nonseizure SUDEP: Sudden unexpected death in epilepsy without preceding epileptic seizures.

Epilepsia. 57: 1161-1168Sveinsson O. Andersson T. Mattsson P. et al.

Clinical risk factors in SUDEP: a nationwide population-based case-control study.

Neurology. 94: e419-e429Hesdorffer D.C. Tomson T. Benn E. et al.

Combined analysis of risk factors for SUDEP.

Epilepsia. 52: 1150-1159Hesdorffer D.C. Tomson T. Benn E. et al.

Do antiepileptic drugs or generalized tonic-clonic seizure frequency increase SUDEP risk? A combined analysis.

Epilepsia. 53: 249-252Langan Y. Nashef L. Sander J.W.

Case-control study of SUDEP.

Neurology. 64: 1131-1133Verducci C. Friedman D. Donner E. et al.

Genetic generalized and focal epilepsy prevalence in the North American SUDEP Registry.

Neurology. 94: e1757-e1763Lamberts R.J. Thijs R.D. Laffan A. et al.

Sudden unexpected death in epilepsy: people with nocturnal seizures may be at highest risk.

Epilepsia. 53: 253-257van der Lende M. Hesdorffer D.C. Sander J.W. et al.

Nocturnal supervision and SUDEP risk at different epilepsy care settings.

Neurology. 91: e1508-e1518Verducci C. Hussain F. Donner E. et al.

SUDEP in the North American SUDEP Registry: The full spectrum of epilepsies.

Neurology. 93: e227-e236Hebel J.M. Surges R. Stodieck S.R.G. et al.

SUDEP following the second seizure in new-onset epilepsy due to limbic encephalitis.

Seizure. 62: 124-126Doumlele K. Friedman D. Buchhalter J. et al.

Sudden unexpected death in epilepsy among patients with benign childhood epilepsy with centrotemporal spikes.

JAMA Neurol. 74: 645-649Jha A. Oh C. Hesdorffer D. et al.

Sudden unexpected death in epilepsy: a personalized prediction tool.

Neurology. 96: e2627-e2638Esmaeili B. Dworetzky B.A. Glynn R.J. et al.

The probability of sudden unexpected death in epilepsy given postictal prone position.

Epilepsy Behav. 116: 107775Aurlien D. Gjerstad L. Taubøll E.

The role of antiepileptic drugs in sudden unexpected death in epilepsy.

Seizure. 43: 56-60Sveinsson O. Andersson T. Mattsson P. et al.

Pharmacologic treatment and SUDEP risk: A nationwide, population-based, case-control study.

Neurology. 95: e2509-e2518Ryvlin P. Cucherat M. Rheims S.

Risk of sudden unexpected death in epilepsy in patients given adjunctive antiepileptic treatment for refractory seizures: a meta-analysis of placebo-controlled randomised trials.

Lancet Neurol. 10: 961-968Cross J.H. Galer B.S. Gil-Nagel A. et al.

Impact of fenfluramine on the expected SUDEP mortality rates in patients with Dravet syndrome.

Seizure. 93: 154-159Ryvlin P. Rheims S. Hirsch L.J. et al.

Neuromodulation in epilepsy: state-of-the-art approved therapies.

Lancet Neurol. 20: 1038-1047Ryvlin P. Cross J.H. Rheims S.

Epilepsy surgery in children and adults.

Lancet Neurol. 13: 1114-1126Henning O. Nakken K.O. Lossius M.I.

People with epilepsy and their relatives want more information about risks of injuries and premature death.

Epilepsy Behav. 82: 6-10Long L. Cotterman-Hart S. Shelby J.

To reveal or conceal? Adult patient perspectives on SUDEP disclosure.

Epilepsy Behav. 86: 79-84Morton B. Richardson A. Duncan S.

Sudden unexpected death in epilepsy (SUDEP): don't ask, don't tell?.

J Neurol Neurosurg Psychiatry. 77: 199-202Asadi-Pooya A.A. Trinka E. Brigo F. et al.

Counseling about sudden unexpected death in epilepsy (SUDEP): A global survey of neurologists' opinions.

Epilepsy Behav. 128: 108570Barra S.N. Providência R. Paiva L. et al.

A review on advanced atrioventricular block in young or middle-aged adults.

Pacing Clin Electrophysiol. 35: 1395-1405Radhakrishnan D.M. Ramanujam B. Srivastava P. et al.

Effect of providing sudden unexpected death in epilepsy (SUDEP) information to persons with epilepsy (PWE) and their caregivers-Experience from a tertiary care hospital.

Acta Neurol Scand. 138: 417-424Shankar R. Henley W. Boland C. et al.

Decreasing the risk of sudden unexpected death in epilepsy: structured communication of risk factors for premature mortality in people with epilepsy.

Eur J Neurol. 25: 1121-1127Surges R. von Wrede R. Porschen T. et al.

Knowledge of sudden unexpected death in epilepsy (SUDEP) among 372 patients attending a German tertiary epilepsy center.

Epilepsy Behav. 80: 360-364

Should all patients be told about sudden unexpected death in epilepsy (SUDEP)? Pros and Cons.

Epilepsia. 49: 99-101Barbour K. Hesdorffer D.C. Tian N. et al.

Automated detection of sudden unexpected death in epilepsy risk factors in electronic medical records using natural language processing.

Epilepsia. 60: 1209-1220Maguire M.J. Jackson C.F. Marson A.G. et al.

Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP).

Cochrane Database Syst Rev. 4: Cd011792Schulz R. Bien C.G. May T.W.

Decreasing SUDEP incidence in a tertiary epilepsy center between 1981 and 2016: Effects of better patient supervision.

Epilepsy Behav. 92: 1-4Ryvlin P. Ciumas C. Wisniewski I. et al.

Wearable devices for sudden unexpected death in epilepsy prevention.

Epilepsia. 59: 61-66Sun J.J. Perera B. Henley W. et al.

Seizure and Sudden Unexpected Death in Epilepsy (SUDEP) characteristics in an urban UK intellectual disability service.

Seizure. 80: 18-23

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