Influence of donor age and comorbidities on transduced human adipose-derived stem cell in vitro osteogenic potential

Collon K, Gallo MC, Lieberman JR. Musculoskeletal tissue engineering: regional gene therapy for bone repair. Biomaterials. 2021;275:120901.

CAS  PubMed  Google Scholar 

Giannoudis PV, Einhorn TA, Marsh D. Fracture healing: the diamond concept. Injury. 2007;38:S3–6.

PubMed  Google Scholar 

Baldwin P, Li DJ, Auston DA, Mir HS, Yoon RS, Koval KJ. Autograft, Allograft, and Bone Graft Substitutes: Clinical Evidence and Indications for Use in the Setting of Orthopaedic Trauma Surgery. J Orthop Trauma. 2019;33:203–13.

PubMed  Google Scholar 

Ahlmann E, Patzakis M, Roidis N, Shepherd L, Holtom P. Comparison of anterior and posterior iliac crest bone grafts in terms of harvest-site morbidity and functional outcomes. J Bone Joint Surg Am. 2002;84:716–20.

PubMed  Google Scholar 

Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7:211–28.

CAS  PubMed  Google Scholar 

Lieberman JR, Daluiski A, Stevenson S, Wu L, McAllister P, Lee YP, et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg Am. 1999;81:905–17.

CAS  PubMed  Google Scholar 

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–7.

CAS  PubMed  Google Scholar 

Chen TL, Bates RL, Dudley A, Hammonds RG Jr., Amento EP. Bone morphogenetic protein-2b stimulation of growth and osteogenic phenotypes in rat osteoblast-like cells: comparison with TGF-beta 1. J Bone Miner Res. 1991;6:1387–93.

CAS  PubMed  Google Scholar 

Cuomo AV, Virk M, Petrigliano F, Morgan EF, Lieberman JR. Mesenchymal stem cell concentration and bone repair: potential pitfalls from bench to bedside. J Bone Joint Surg Am. 2009;91:1073–83.

PubMed  Google Scholar 

Ihn H, Kang H, Iglesias B, Sugiyama O, Tang A, Hollis R, et al. Regional Gene Therapy with Transduced Human Cells: The Influence of “Cell Dose” on Bone Repair. Tissue Eng Part A. 2021;27:1422–33.

CAS  PubMed  Google Scholar 

Feeley BT, Conduah AH, Sugiyama O, Krenek L, Chen IS, Lieberman JR. In vivo molecular imaging of adenoviral versus lentiviral gene therapy in two bone formation models. J Orthop Res. 2006;24:1709–21.

CAS  PubMed  Google Scholar 

Musgrave DS, Bosch P, Lee JY, Pelinkovic D, Ghivizzani SC, Whalen J, et al. Ex vivo gene therapy to produce bone using different cell types. Clin Orthop Relat Res. 2000;378:290–305.

Vakhshori V, Bougioukli S, Sugiyama O, Kang HP, Tang AH, Park SH, et al. Ex vivo regional gene therapy with human adipose-derived stem cells for bone repair. Bone. 2020;138:115524.

CAS  PubMed  PubMed Central  Google Scholar 

Pelled G, Sheyn D, Tawackoli W, Jun DS, Koh Y, Su S, et al. BMP6-Engineered MSCs Induce Vertebral Bone Repair in a Pig Model: A Pilot Study. Stem Cells Int. 2016;2016:6530624.

PubMed  Google Scholar 

Miyazaki M, Zuk PA, Zou J, Yoon SH, Wei F, Morishita Y, et al. Comparison of human mesenchymal stem cells derived from adipose tissue and bone marrow for ex vivo gene therapy in rat spinal fusion model. Spine (Phila Pa 1976). 2008;33:863–9.

Google Scholar 

Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation. 1968;6:230–47.

CAS  PubMed  Google Scholar 

Via AG, Frizziero A, Oliva F. Biological properties of mesenchymal Stem Cells from different sources. Muscles Ligaments Tendons J. 2012;2:154–62.

PubMed  Google Scholar 

Hass R, Kasper C, Böhm S, Jacobs R. Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal. 2011;9:12.

CAS  PubMed  PubMed Central  Google Scholar 

Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13:4279–95.

CAS  PubMed  PubMed Central  Google Scholar 

Liao HT, Chen CT. Osteogenic potential: comparison between bone marrow and adipose-derived mesenchymal stem cells. World J Stem Cells. 2014;6:288–95.

PubMed  PubMed Central  Google Scholar 

Zhu Y, Liu T, Song K, Fan X, Ma X, Cui Z. Adipose-derived stem cell: a better stem cell than BMSC. Cell Biochem Funct. 2008;26:664–75.

CAS  PubMed  Google Scholar 

Dragoo JL, Choi JY, Lieberman JR, Huang J, Zuk PA, Zhang J, et al. Bone induction by BMP-2 transduced stem cells derived from human fat. J Orthop Res. 2003;21:622–9.

CAS  PubMed  Google Scholar 

Bougioukli S, Sugiyama O, Pannell W, Ortega B, Tan MH, Tang AH, et al. Gene Therapy for Bone Repair Using Human Cells: Superior Osteogenic Potential of Bone Morphogenetic Protein 2-Transduced Mesenchymal Stem Cells Derived from Adipose Tissue Compared to Bone Marrow. Hum Gene Ther. 2018;29:507–19.

CAS  PubMed  PubMed Central  Google Scholar 

Maredziak M, Marycz K, Tomaszewski KA, Kornicka K, Henry BM. The Influence of Aging on the Regenerative Potential of Human Adipose Derived Mesenchymal Stem Cells. Stem Cells Int. 2016;2016:2152435.

PubMed  PubMed Central  Google Scholar 

Kornicka K, Marycz K, Tomaszewski KA, Marędziak M, Śmieszek A. The Effect of Age on Osteogenic and Adipogenic Differentiation Potential of Human Adipose Derived Stromal Stem Cells (hASCs) and the Impact of Stress Factors in the Course of the Differentiation Process. Oxid Med Cell Longev. 2015;2015:309169.

PubMed  PubMed Central  Google Scholar 

Dufrane D. Impact of Age on Human Adipose Stem Cells for Bone Tissue Engineering. Cell Transplant. 2017;26:1496–504.

PubMed  PubMed Central  Google Scholar 

Mantovani C, Raimondo S, Haneef MS, Geuna S, Terenghi G, Shawcross SG, et al. Morphological, molecular and functional differences of adult bone marrow- and adipose-derived stem cells isolated from rats of different ages. Exp Cell Res. 2012;318:2034–48.

CAS  PubMed  Google Scholar 

Beane OS, Fonseca VC, Cooper LL, Koren G, Darling EM. Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/stromal cells. PLoS ONE. 2014;9:e115963.

PubMed  PubMed Central  Google Scholar 

de Girolamo L, Lopa S, Arrigoni E, Sartori MF, Baruffaldi Preis FW, Brini AT. Human adipose-derived stem cells isolated from young and elderly women: their differentiation potential and scaffold interaction during in vitro osteoblastic differentiation. Cytotherapy. 2009;11:793–803.

PubMed  Google Scholar 

Payr S, Schuseil T, Unger M, Seeliger C, Tiefenboeck T, Balmayor ER, et al. Effect of donor age and 3D-cultivation on osteogenic differentiation capacity of adipose-derived mesenchymal stem cells. Sci Rep. 2020;10:10408.

CAS  PubMed  PubMed Central  Google Scholar 

Chen HT, Lee MJ, Chen CH, Chuang SC, Chang LF, Ho ML, et al. Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures. J Cell Mol Med. 2012;16:582–93.

CAS  PubMed  PubMed Central  Google Scholar 

Dzhoyashvili NA, Efimenko AY, Kochegura TN, Kalinina NI, Koptelova NV, Sukhareva OY, et al. Disturbed angiogenic activity of adipose-derived stromal cells obtained from patients with coronary artery disease and diabetes mellitus type 2. J Transl Med. 2014;12:337.

PubMed  PubMed Central  Google Scholar 

Espagnolle N, Hebraud B, Descamps JG, Gadelorge M, Joubert MV, Ferreira LDS, et al. Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells. Stem Cells Int. 2020;2020:4173578.

PubMed  PubMed Central  Google Scholar 

Frazier TP, Gimble JM, Devay JW, Tucker HA, Chiu ES, Rowan BG. Body mass index affects proliferation and osteogenic differentiation of human subcutaneous adipose tissue-derived stem cells. BMC Cell Biol. 2013;14:34.

CAS  PubMed  PubMed Central  Google Scholar 

Yang HJ, Kim KJ, Kim MK, Lee SJ, Ryu YH, Seo BF, et al. The stem cell potential and multipotency of human adipose tissue-derived stem cells vary by cell donor and are different from those of other types of stem cells. Cells Tissues Organs. 2014;199:373–83.

PubMed  Google Scholar 

Zhang M, Li Y, Rao P, Huang K, Luo D, Cai X, et al. Blockade of receptors of advanced glycation end products ameliorates diabetic osteogenesis of adipose-derived stem cells through DNA methylation and Wnt signalling pathway. Cell Prolif. 2018;51:e12471.

PubMed  PubMed Central  Google Scholar 

Zhu M, Heydarkhan-Hagvall S, Hedrick M, Benhaim P, Zuk P. Manual isolation of adipose-derived stem cells from human lipoaspirates. J Vis Exp. 2013;79:e50585.

Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–7.

CAS  PubMed  Google Scholar 

Alaee F, Bartholomae C, Sugiyama O, Virk MS, Drissi H, Wu Q, et al. Biodistribution of LV-TSTA transduced rat bone marrow cells used for “ex-vivo” regional gene therapy for bone repair. Curr Gene Ther. 2015;15:481–91.

CAS  PubMed  Google Scholar 

Iyer M, Wu L, Carey M, Wang Y, Smallwood A, Gambhir SS. Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters. Proc Natl Acad Sci USA. 2001;98:14595–600.

CAS  PubMed  PubMed Central  Google Scholar 

Virk MS, Sugiyama O, Park SH, Gambhir SS, Adams DJ, Drissi H, et al. “Same day” ex-vivo regional gene therapy: a novel strategy to enhance bone repair. Mol Ther. 2011;19:960–8.

CAS  PubMed  PubMed Central  Google Scholar 

Virk MS, Conduah A, Park SH, Liu N, Sugiyama O, Cuomo A, et al. Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model. Bone. 2008;42:921–31.

CAS  PubMed  Google Scholar 

Zhan XS, El-Ashram S, Luo DZ, Luo HN, Wang BY, Chen SF, et al. A Comparative Study of Biological Characteristics and Transcriptome Profiles of Mesenchymal Stem Cells from Different Canine Tissues. Int J Mol Sci. 2019;20:1–16.

Gregory CA, Gunn WG, Peister A, Prockop DJ. An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Anal Biochem. 2004;329:77–84.

CAS  PubMed 

留言 (0)

沒有登入
gif