ERLEADA (apalutamide) [prescribing information]. Janssen Pharmaceutical Companies, Horsham, PA; 2020.

ERLEADA (apalutamide). [Summary of Product Characteristics]. The electronic Medicines Compendium (eMC) Web site (https://www.ema.europa.eu/en/documents/product-information/erleada-epar-product-information_en.pdf) and https://www.ema.europa.eu/en/medicines/human/EPAR/erleada.

Smith MR, Saad F, Chowdhury S, Oudard S, Hadaschik BA, Graff JN, et al. Apalutamide and overall survival in prostate cancer. Eur Urol. 2021;79:150–8.

CAS  Article  Google Scholar 

Smith MR, Saad F, Chowdhury S, Oudard S, Hadaschik BA, Graff JN, et al. Apalutamide treatment and metastasis-free survival in prostate cancer. N. Engl J Med. 2018;378:1408–18.

CAS  Article  Google Scholar 

Saad F, Cella D, Basch E, Hadaschik BA, Mainwaring PN, Oudard S, et al. Effect of apalutamide on health-related quality of life in patients with non-metastatic castration-resistant prostate cancer: an analysis of the SPARTAN randomised, placebo-controlled, phase 3 trial. Lancet Oncol. 2018;19:1404–16.

CAS  Article  Google Scholar 

Oudard S, Hadaschik BA, Saad F, Cella D, Basch E, Mainwaring PN, et al. Health-related quality of life (HRQoL) at final analysis of the SPARTAN study of apalutamide (APA) vs placebo (PBO) in patients (pts) with non-metastatic castration-resistant prostate cancer (nmCRPC) receiving androgen deprivation therapy (ADT). Ann Oncol. 2020;31:S521. 632P

Article  Google Scholar 

Myint ZW, Momo HD, Otto DE, Yan D, Wang P, Kolesar JM. Evaluation of fall and fracture risk among men with prostate cancer treated with androgen receptor inhibitors: A systematic review and meta-analysis. JAMA Netw Open. 2020;3:e2025826.

Article  Google Scholar 

Hussain S, Breunis H, Timilshina N, Alibhai S. Falls in men on androgen deprivation therapy for prostate cancer. J Geriatr Oncol. 2010;1:32–39.

Article  Google Scholar 

Winters-Stone KM, Moe E, Graff JN, Dieckmann NF, Stoyles S, Borsch C, et al. Falls and frailty in prostate cancer survivors: current, past, and never users of androgen deprivation therapy. J Am Geriatr Soc. 2017;65:1414–9.

Article  Google Scholar 

Wu FJ, Sheu SY, Lin HC, Chung SD. Increased fall risk in patients receiving androgen deprivation therapy for prostate cancer. Urology. 2016;95:145–50.

Article  Google Scholar 

Small EJ, Saad F, Chowdhury S, Oudard S, Hadaschik BA, Graff JN, et al. Apalutamide and overall survival in non-metastatic castration-resistant prostate cancer. Ann Oncol. 2019;30:1813–20.

CAS  Article  Google Scholar 

Panel on Prevention of Falls in Older Persons, American Geriatrics Society, British Geriatrics Society. Summary of the Updated American Geriatrics Society/British Geriatrics Society clinical practice guideline for prevention of falls in older persons. J Am Geriatr Soc. 2011;59:148–57.

Article  Google Scholar 

National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) v4.0. https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm#ctc_40.

Burns E, Kakara R. Deaths from falls among persons aged ≥65 years—United States, 2007-2016. MMWR Morb Mortal Wkly Rep. 2018;67:509–14.

Article  Google Scholar 

Toomey A, Friedman L. Mortality in cancer patients after a fall-related injury: the impact of cancer spread and type. Injury. 2014;45:1710–6.

Article  Google Scholar 

Sterling DA, O’Connor JA, Bonadies J. Geriatric falls: injury severity is high and disproportionate to mechanism. J Trauma. 2001;50:116–9.

CAS  Article  Google Scholar 

Bergen G, Stevens MR, Burns ER. Falls and fall injuries among adults aged ≥65 years—United States, 2014. MMWR Morb Mortal Wkly Rep. 2016;65:993–8.

Article  Google Scholar 

Centers for Disease Control and Prevention. Older adult falls: important facts about falls. https://www.cdc.gov/homeandrecreationalsafety/falls/adultfalls.html.

Tinetti ME, Gordon C, Sogolow E, Lapin P, Bradley EH. Fall-risk evaluation and management: challenges in adopting geriatric care practices. Gerontologist. 2006;46:717–25.

Article  Google Scholar 

Wildes TM, Dua P, Fowler SA, Miller JP, Carpenter CR, Avidan MS, et al. Systematic review of falls in older adults with cancer. J Geriatr Oncol. 2015;6:70–83.

Article  Google Scholar 

Huang MH, Blackwood J, Godoshian M, Pfalzer L. Factors associated with self-reported falls, balance or walking difficulty in older survivors of breast, colorectal, lung, or prostate cancer: results from Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey linkage. PLoS One. 2018;13:e0208573.

CAS  Article  Google Scholar 

Mohile SG, Fan L, Reeve E, Jean-Pierre P, Mustian K, Peppone L, et al. Association of cancer with geriatric syndromes in older Medicare beneficiaries. J Clin Oncol. 2011;29:1458–64.

Article  Google Scholar 

Guerard EJ, Deal AM, Williams GR, Jolly TA, Nyrop KA, Muss HB. Falls in older adults with cancer: evaluation by oncology providers. J Oncol Pr. 2015;11:470–4.

Article  Google Scholar 

Centers for Disease Control and Prevention. Algorithm for fall risk screening, assessment, and intervention. https://www.cdc.gov/steadi/pdf/STEADI-Algorithm-508.pdf.

Stone CA, Lawlor PG, Savva GM, Bennett K, Kenny RA. Prospective study of falls and risk factors for falls in adults with advanced cancer. J Clin Oncol. 2012;30:2128–33.

Article  Google Scholar 

Vande Walle N, Kenis C, Heeren P, Van Puyvelde K, Decoster L, Beyer I, et al. Fall predictors in older cancer patients: a multicenter prospective study. BMC Geriatr. 2014;14:135.

Article  Google Scholar 

Williams GR, Deal AM, Nyrop KA, Pergolotti M, Guerard EJ, Jolly TA, et al. Geriatric assessment as an aide to understanding falls in older adults with cancer. Support Care Cancer. 2015;23:2273–80.

Article  Google Scholar