Crowley VE, Yeo GS, O’Rahilly S. Obesity therapy: altering the energy intake-and-expenditure balance sheet. Nat Rev Drug Discov. 2002;1:276–86.
CAS PubMed Article Google Scholar
Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev. 2004;84:277–359.
CAS PubMed Article Google Scholar
Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012;150:366–76.
CAS PubMed PubMed Central Article Google Scholar
Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014;156:304–16.
CAS PubMed PubMed Central Article Google Scholar
Cipolla-Neto J, Amaral FG, Afeche SC, Tan DX, Reiter RJ. Melatonin, energy metabolism, and obesity: a review. J Pineal Res. 2014;56:371–81.
CAS PubMed Article Google Scholar
Yin J, Li Y, Han H, Chen S, Gao J, Liu G, et al. Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high-fat diet-fed mice. J Pineal Res. 2018;65:e12524.
Stacchiotti A, Grossi I, Garcia-Gomez R, Patel GA, Salvi A, Lavazza A, et al. Melatonin effects on non-alcoholic fatty liver disease are related to microRNA-34a-5p/Sirt1 axis and autophagy. Cells. 2019;8:1053.
CAS PubMed Central Article Google Scholar
de Farias T, Cruz MM, de Sa R, Severi I, Perugini J, Senzacqua M, et al. Melatonin supplementation decreases hypertrophic obesity and inflammation induced by high-fat diet in mice. Front Endocrinol (Lausanne). 2019;10:750.
Wolden-Hanson T, Mitton DR, McCants RL, Yellon SM, Wilkinson CW, Matsumoto AM, et al. Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology. 2000;141:487–97.
CAS PubMed Article Google Scholar
Agil A, Navarro-Alarcon M, Ruiz R, Abuhamadah S, El-Mir MY, Vazquez GF. Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats. J Pineal Res. 2011;50:207–12.
Raskind MA, Burke BL, Crites NJ, Tapp AM, Rasmussen DD. Olanzapine-induced weight gain and increased visceral adiposity is blocked by melatonin replacement therapy in rats. Neuropsychopharmacology. 2007;32:284–8.
CAS PubMed Article Google Scholar
Fernandez Vazquez G, Reiter RJ, Agil A. Melatonin increases brown adipose tissue mass and function in Zucker diabetic fatty rats: implications for obesity control. J Pineal Res. 2018;64:e12472.
Tan DX, Manchester LC, Fuentes-Broto L, Paredes SD, Reiter RJ. Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity. Obes Rev. 2011;12:167–88.
CAS PubMed Article Google Scholar
Halpern B, Mancini MC, Bueno C, Barcelos IP, de Melo ME, Lima MS, et al. Melatonin increases brown adipose tissue volume and activity in patients with melatonin deficiency: a proof-of-concept study. Diabetes. 2019;68:947–52.
CAS PubMed Article Google Scholar
Jimenez-Aranda A, Fernandez-Vazquez G, Campos D, Tassi M, Velasco-Perez L, Tan DX, et al. Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats. J Pineal Res. 2013;55:416–23.
CAS PubMed Article Google Scholar
Cuevas-Ramos D, Mehta R, Aguilar-Salinas CA. Fibroblast growth factor 21 and browning of white adipose tissue. Front Physiol. 2019;10:37.
PubMed PubMed Central Article Google Scholar
Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, Liu F, et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 2008;57:1246–53.
CAS PubMed Article Google Scholar
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012;26:271–81.
CAS PubMed PubMed Central Article Google Scholar
Zhou H, Li D, Zhu P, Ma Q, Toan S, Wang J, et al. Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury. J Pineal Res. 2018;65:e12503.
Zhou H, Du W, Li Y, Shi C, Hu N, Ma S et al. Effects of melatonin on fatty liver disease: the role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy. J Pineal Res. 2018. https://doi.org/10.1111/jpi.12450.
Rong B, Feng R, Liu C, Wu Q, Sun C. Reduced delivery of epididymal adipocyte-derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice. J Pineal Res. 2019;66:e12561.
Xu L, Nagata N, Nagashimada M, Zhuge F, Ni Y, Chen G, et al. SGLT2 inhibition by empagliflozin promotes fat utilization and browning and attenuates inflammation and insulin resistance by polarizing M2 macrophages in diet-induced obese mice. EBioMedicine. 2017;20:137–49.
PubMed PubMed Central Article Google Scholar
Ni Y, Nagashimada M, Zhuge F, Zhan L, Nagata N, Tsutsui A, et al. Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: a comparison with vitamin E. Sci Rep. 2015;5:17192.
CAS PubMed PubMed Central Article Google Scholar
Ni Y, Nagashimada M, Zhan L, Nagata N, Kobori M, Sugiura M, et al. Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, beta-cryptoxanthin. Endocrinology. 2015;156:987–99.
CAS PubMed Article Google Scholar
Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, et al. CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Diabetes. 2012;61:1680–90.
CAS PubMed PubMed Central Article Google Scholar
Muller TD, Klingenspor M, Tschop MH. Revisiting energy expenditure: how to correct mouse metabolic rate for body mass. Nat Metab. 2021;3:1134–6.
Julien SG, Kim SY, Brunmeir R, Sinnakannu JR, Ge X, Li H, et al. Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle. PLoS Biol. 2017;15:e1002597.
PubMed PubMed Central Article Google Scholar
Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, et al. FGF-21 as a novel metabolic regulator. J Clin Invest. 2005;115:1627–35.
CAS PubMed PubMed Central Article Google Scholar
Hua L, Zhuo Y, Jiang D, Li J, Huang X, Zhu Y, et al. Identification of hepatic fibroblast growth factor 21 as a mediator in 17beta-estradiol-induced white adipose tissue browning. FASEB J. 2018;32:5602–11.
CAS PubMed Article Google Scholar
Yin J, Li Y, Han H, Ma J, Liu G, Wu X, et al. Administration of exogenous melatonin improves the diurnal rhythms of the gut microbiota in mice fed a high-fat diet. mSystems. 2020;5:e00002-20.
PubMed PubMed Central Article Google Scholar
Prunet-Marcassus B, Desbazeille M, Bros A, Louche K, Delagrange P, Renard P, et al. Melatonin reduces body weight gain in sprague dawley rats with diet-induced obesity. Endocrinology. 2003;144:5347–52.
CAS PubMed Article Google Scholar
Angers K, Haddad N, Selmaoui B, Thibault L. Effect of melatonin on total food intake and macronutrient choice in rats. Physiol Behav. 2003;80:9–18.
CAS PubMed Article Google Scholar
Bubenik GA, Pang SF. The role of serotonin and melatonin in gastrointestinal physiology: ontogeny, regulation of food intake, and mutual serotonin-melatonin feedback. J Pineal Res. 1994;16:91–9.
CAS PubMed Article Google Scholar
Ravussin E, Galgani JE. The implication of brown adipose tissue for humans. Annu Rev Nutr. 2011;31:33–47.
CAS PubMed PubMed Central Article Google Scholar
Heldmaier G, Hoffmann K. Melatonin stimulates growth of brown adipose tissue. Nature. 1974;247:224–5.
CAS PubMed Article Google Scholar
Heldmaier G, Steinlechner S, Rafael J, Vsiansky P. Photoperiodic control and effects of melatonin on nonshivering thermogenesis and brown adipose tissue. Science. 1981;212:917–9.
CAS PubMed Article Google Scholar
Holtorf AP, Heldmaier G, Thiele G, Steinlechner S. Diurnal changes in sensitivity to melatonin in intact and pinealectomized Djungarian hamsters: effects on thermogenesis, cold tolerance, and gonads. J Pineal Res. 1985;2:393–403.
CAS PubMed Article Google Scholar
Halpern B, Mancini MC, Mendes C, Machado CML, Prando S, Sapienza MT, et al. Melatonin deficiency decreases brown adipose tissue acute thermogenic capacity of in rats measured by (18)F-FDG PET. Diabetol Metab Syndr. 2020;12:82.
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