World Health Organization, Chagas Disease. www.who.int/health-topics/chagas-disease, 2022 (accessed 04 May 2022).

Coura JR. The main sceneries of chagas disease transmission. The vectors, blood and oral transmissions—A comprehensive review. Mem Inst Oswaldo Cruz. 2015;110:277–82. https://doi.org/10.1590/0074-0276140362.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Scarim CB, Chung CM. Nitroheterocyclic derivatives: privileged scaffold for drug development against Chagas disease. Med Chem Res. 2019;28:2099–108. https://doi.org/10.1007/s00044-019-02453-y.

CAS  Article  Google Scholar 

Jackson Y, Alirol E, Getaz L, Wolff H, Combescure C, Chappuis F. Tolerance and safety of nifurtimox in patients with chronic Chagas disease. Clin Infect Dis. 2010;51:e69-e75. https://doi.org/10.1086/656917.

CAS  Article  Google Scholar 

Olivera MJ, Fory JA, Olivera AJ. Therapeutic drug monitoring of benznidazole and nifurtimox: A systematic review and quality assessment of published clinical practice guidelines. Rev Soc Bras Med Trop. 2017;50:748–55. https://doi.org/10.1590/0037-8682-0399-2016.

Article  PubMed  Google Scholar 

Azevedo-Barbosa H, Ferreira-Silva GA, Silva CF, Souza TB, Dias DF, Paula ACC, Ionta M, Carvalho DT. Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E down-regulation and induces cell cycle arrest at G1/S transition in estrogen-positive MCF-7 cell line. Toxicol Vitr. 2019;59:150–60. https://doi.org/10.1016/j.tiv.2019.04.023.

CAS  Article  Google Scholar 

Daniel AN, Sartoretto SM, Schmidt G, Caparroz-Assef SM, Bersani-Amado CA, Kenji R, Cuman N. Anti-inflammatory and antinociceptive activities of eugenol essential oil in experimental animal models. Rev Bras Farmacogn. 2009;19:212–7.

CAS  Article  Google Scholar 

Souza TB, Raimundo POB, Andrade SF, Hipólito TMM, Silva NC, Dias ALT, Ikegaki M, Rocha RP, Coelho LFL, Veloso MP, Carvalho DT, Dias DF. Synthesis and antimicrobial activity of 6-triazolo-6-deoxy eugenol glucosides. Carbohydr Res 2015;41:1–8. https://doi.org/10.1016/j.carres.2015.04.002.

CAS  Article  Google Scholar 

Machado M, Dinis AM, Salgueiro L, Custódio JBA, Cavaleiro C, Sousa MC. Anti-Giardia activity of Syzygium aromaticum essential oil and eugenol: effects on growth, viability, adherence, and ultrastructure. Exp Parasitol. 2011;127:732–9. https://doi.org/10.1016/j.exppara.2011.01.011.

CAS  Article  PubMed  Google Scholar 

Souza TB, Caldas IS, Paula FR, Rodrigues CC, Carvalho DT, Dias DF. Synthesis, activity, and molecular modeling studies of 1,2,3‐triazole derivatives from natural phenylpropanoids as new trypanocidal agents. Chem Biol Drug Des. 2020;95:124–9. https://doi.org/10.1111/cbdd.13628.

CAS  Article  PubMed  Google Scholar 

Alkhaldi AAM, Koning HP, Bukhari SNA. Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds. Drug Des Devel Ther. 2019;13:1179–85. https://doi.org/10.2147/DDDT.S204733.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Braga SFP, Alves EVP, Ferreira RS, Fradico JRP, Lage PS, Duarte MC, Ribeiro TG, Júnior PAS, Romanha AJ, Tonini ML, Steindel M, Coelho EF, Oliveira RB. Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones. Eur J Med Chem. 2014;71:282–9. https://doi.org/10.1016/j.ejmech.2013.11.011.

CAS  Article  PubMed  Google Scholar 

Brancaglion GA, Toyota AR, Machado JVC, Júnior AAF, Silveira AT, Vilas Boas AF, Santos EG, Caldas IS, Carvalho DT. In vitro and in vivo trypanocidal activities of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2H-cromen-2-one, a new synthetic coumarin of low cytotoxicity against mammalian cells. Chem Biol Drug Des. 2018;92:1888–98. https://doi.org/10.1111/cbdd.13362.

CAS  Article  PubMed  Google Scholar 

Brandão GC, Kroon EG, Souza DER, Filho JDS, Oliveira AB. Chemistry and antiviral activity of Arrabidaea pulchra (Bignoniaceae). Molecules 2013;18:9919–32. https://doi.org/10.3390/molecules18089919.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Twentyman PR, Luscombe M. A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity. Br J Cancer. 1987;56:279–85. https://doi.org/10.1038/bjc.1987.190.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Romanha AJ, et al. In vitro and in vivo experimental models for drug screening and development for Chagas disease. Mem Inst Oswaldo Cruz. 2010;105:233–8.

CAS  Article  Google Scholar 

Sales-Junior PA, Junior COR, Hyaric ML, Almeida MV, Romanha AJ. The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms. Mem Inst Oswaldo Cruz. 2014;109:362–4.

Article  Google Scholar 

Buckner FS, Verlinde CL, Flamme ACL, Vooorhis WCV. Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase. Antimicrob Agents Chemother. 1996;40:2592–7.

CAS  Article  Google Scholar