Background: The published researches regarding the use of contrast media(CM) in patients taking metformin were very scarce.we conducted a systematic review and meta-analysis to explore the relationship between metformin and contrast-induced acute kidney injury(CI-AKI). Methods: We conducted comprehensive search for literature on associations between MAC and AF using the following databases: MEDLINE, PubMed, Embase, and the Web of Science. The pooled odds ratio (OR) or relative risk and the corresponding 95% confidence intervals (CIs) were calculated to assess the relationship between metformin and CI-AKI, as well as the incidence of lactic acidosis(LA). Results: 7 studies met our eligibility criteria on associations between metformin and CI-AKI, consisting of 2,325 individuals, including 279 cases of new CI-AKI patients during CM exposure. The pooled analysis demonstrated no statistically elevated risk of development CI-AKI in patients with uninterrupted use of metformin (Random-effects OR: 1.15, 95%CI: 0.70, 1.90; P =0.57). No cases of LA occurred during CM exposure. Conclusion: Metformin can be safely applied in patients with moderate renal impairment as low as eGFR ≥30 ml/min/1.73 m2 during the exposure of the CM.

The Author(s). Published by S. Karger AG, Basel