Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Rizzoli R, Reginster JY, Arnal JF, Bautmans I, Beaudart C, Bischoff-Ferrari H, Biver E, Boonen S, Brandi ML, Chines A, Cooper C, Epstein S, Fielding RA, Goodpaster B, Kanis JA, Kaufman JM, Laslop A, Malafarina V, Manas LR, Mitlak BH, Oreffo RO, Petermans J, Reid K, Rolland Y, Sayer AA, Tsouderos Y, Visser M, Bruyere O. Quality of life in sarcopenia and frailty. Calcif Tissue Int. 2013;93(2):101–20.

Article  CAS  Google Scholar 

Goates S, Du K, Arensberg MB, Gaillard T, Guralnik J, Pereira SL. Economic impact of hospitalizations in US adults with sarcopenia. J Frailty Aging. 2019;8(2):93–9.

PubMed  CAS  Google Scholar 

C. Nordic Burden of Disease. Life expectancy and disease burden in the nordic countries: results from the global burden of diseases, injuries, and risk factors study 2017. Lancet Public Health. 2019;4(12):e658–69.

Article  Google Scholar 

Jiahao L, Jiajin L, Yifan L. Effects of resistance training on insulin sensitivity in the elderly: a meta-analysis of randomized controlled trials. J Exerc Sci Fit. 2021;19(4):241–51.

Article  Google Scholar 

Grgic J, Garofolini A, Orazem J, Sabol F, Schoenfeld BJ, Pedisic Z. Effects of resistance training on muscle size and strength in very elderly adults: a systematic review and meta-analysis of randomized controlled trials. Sports Med. 2020;50(11):1983–99.

Article  Google Scholar 

Ramos-Campo DJ, Andreu-Caravaca L, Carrasco-Poyatos M, Benito PJ, Rubio-Arias JA. Effects of circuit resistance training on body composition, strength, and cardiorespiratory fitness in middle-aged and older women: a systematic review and meta-analysis. J Aging Phys Act. 2021;30:1–14.

Pillon NJ, Gabriel BM, Dollet L, Smith JAB, SardonPuig L, Botella J, Bishop DJ, Krook A, Zierath JR. Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity. Nat Commun. 2020;11(1):470.

Article  CAS  Google Scholar 

Lavin KM, Bell MB, McAdam JS, Peck BD, Walton RG, Windham ST, Tuggle SC, Long DE, Kern PA, Peterson CA, Bamman MM. Muscle transcriptional networks linked to resistance exercise training hypertrophic response heterogeneity. Physiol Genomics. 2021;53(5):206–21.

Article  CAS  Google Scholar 

Raue U, Trappe TA, Estrem ST, Qian HR, Helvering LM, Smith RC, Trappe S. Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults. J Appl Physiol. 2012;112(10):1625–36.

Article  CAS  Google Scholar 

Olstad OK, Gautvik VT, LeBlanc M, Kvernevik KJ, Utheim TP, Runningen A, Wiig H, Kirkegaard C, Raastad T, Reppe S, Gautvik KM. Postmenopausal osteoporosis is a musculoskeletal disease with a common genetic trait which responds to strength training: a translational intervention study. Ther Adv Musculoskelet Dis In press. 2020;12:1759720X20929443.

Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo CL, Atkins JL, Lewis JR, Duong T, Hong S, Biggs ML, Luan J, Sarnowski C, Lunetta KL, Tanaka T, Wojczynski MK, Cvejkus R, Nethander M, Ghasemi S, Yang J, Zillikens MC, Walter S, Sicinski K, Kague E, Ackert-Bicknell CL, Arking DE, Windham BG, Boerwinkle E, Grove ML, Graff M, Spira D, Demuth I, van der Velde N, de Groot L, Psaty BM, Odden MC, Fohner AE, Langenberg C, Wareham NJ, Bandinelli S, van Schoor NM, Huisman M, Tan Q, Zmuda J, Mellstrom D, Karlsson M, Bennett DA, Buchman AS, De Jager PL, Uitterlinden AG, Volker U, Kocher T, Teumer A, Rodriguez-Manas L, Garcia FJ, Carnicero JA, Herd P, Bertram L, Ohlsson C, Murabito JM, Melzer D, Kuchel GA, Ferrucci L, Karasik D, Rivadeneira F, Kiel DP, Pilling LC. Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nat Commun. 2021;12(1):654.

Article  CAS  Google Scholar 

Raastad T, Kvernevik KJ, Johansen M, Runningen A, Dullerud R, Kvamme N, Solberg P, Gautvik KM. Marked Improvement in Physical Function through Gains in Muscle Strength and Thigh Muscle Size after Heavy-Load Strength Training in Women with Established Postmenopausal Osteoporosis. J Osteopor Phys Act. 2015;3:8.

Google Scholar 

Reppe S, Refvem H, Gautvik VT, Olstad OK, Hovring PI, Reinholt FP, Holden M, Frigessi A, Jemtland R, Gautvik KM. Eight genes are highly associated with BMD variation in postmenopausal Caucasian women. Bone. 2010;46(3):604–12.

Article  CAS  Google Scholar 

Buyers P, Smith R. Trephine for full-thickness iliac-crest biopsy. Br Med J. 1967;1(5541):682–3.

Article  Google Scholar 

Fonseca J, Machado FVC, Santin LC, Andrello AC, Schneider LP, Fernandes Belo L, Rodrigues A, FernandesRugila D, Furlanetto KC, Hernandes NA, Pitta F. Handgrip strength as a reflection of general muscle strength in chronic obstructive pulmonary disease. COPD. 2021;18(3):299–306.

Article  Google Scholar 

Fragala MS, Alley DE, Shardell MD, Harris TB, McLean RR, Kiel DP, Cawthon PM, Dam TT, Ferrucci L, Guralnik JM, Kritchevsky SB, Vassileva MT, Gudnason V, Eiriksdottir G, Koster A, Newman A, Siggeirsdottir K, Satterfield S, Studenski SA, Kenny AM. Comparison of handgrip and leg extension strength in predicting slow gait speed in older adults. J Am Geriatr Soc. 2016;64(1):144–50.

Article  Google Scholar 

Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulos GD, Glass DJ. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol. 2001;3(11):1009–13.

Article  CAS  Google Scholar 

Ranjbar K, Fayazi B. Vascularisation of Skeletal Muscle. In: Valarmathi MT, editor. Muscle Cells - Recent Advances and Future Perspectives. IntechOpen Book Series; 2020. 1. https://doi.org/10.5772/intechopen.77689. ISBN978-1-78923-968-3. https://www.intechopen.com/books/7870.

Groennebaek T, Vissing K. Impact of Resistance Training on Skeletal Muscle Mitochondrial Biogenesis, Content, and Function. Front Physiol. 2017;8:713.

Article  Google Scholar 

Grevendonk L, Connell NJ, McCrum C, Fealy CE, Bilet L, Bruls YMH, Mevenkamp J, Schrauwen-Hinderling VB, Jorgensen JA, Moonen-Kornips E, Schaart G, Havekes B, de Vogel-van J, den Bosch MCE, Bragt K, Meijer P, Schrauwen JH. Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function. Nat Commun. 2021;12(1):4773.

Article  CAS  Google Scholar 

Porter C, Reidy PT, Bhattarai N, Sidossis LS, Rasmussen BB. Resistance exercise training alters mitochondrial function in human skeletal muscle. Med Sci Sports Exerc. 2015;47(9):1922–31.

Article  CAS  Google Scholar 

Holloszy JO. Regulation of mitochondrial biogenesis and GLUT4 expression by exercise. Compr Physiol. 2011;1(2):921–40.

Article  Google Scholar 

Memme JM, Hood DA. Molecular Basis for the Therapeutic Effects of Exercise on Mitochondrial Defects. Front Physiol. 2020;11:615038.

Article  Google Scholar 

Zhu Y, Gui W, Tan B, Du Y, Zhou J, Wu F, Li H, Lin X. IGF2 deficiency causes mitochondrial defects in skeletal muscle. Clin Sci (Lond). 2021;135(7):979–90.

Article  CAS  Google Scholar 

Lyons A, Coleman M, Riis S, Favre C, O’Flanagan CH, Zhdanov AV, Papkovsky DB, Hursting SD, O’Connor R. Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells. J Biol Chem. 2017;292(41):16983–98.

Article  CAS  Google Scholar 

Hou X, Li Z, Higashi Y, Delafontaine P, Sukhanov S. Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy. J Aging Res. 2020;2020:4939310.

Article  Google Scholar 

Riis S, Murray JB, O’Connor R. IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3beta-Nrf2-BNIP3 Pathway. Cells. 2020;9(1):147.

Article  CAS  Google Scholar 

Verdijk LB, Snijders T, Holloway TM, Kranenburg JVAN. LCCVAN Loon, Resistance Training Increases Skeletal Muscle Capillarization in Healthy Older Men. Med Sci Sports Exerc. 2016;48(11):2157–64.

Article  CAS  Google Scholar 

Snijders T, Nederveen JP, Joanisse S, Leenders M, Verdijk LB, van Loon LJ, Parise G. Muscle fibre capillarization is a critical factor in muscle fibre hypertrophy during resistance exercise training in older men. J Cachexia Sarcopenia Muscle. 2017;8(2):267–76.

Article  Google Scholar 

Njalsson R. Glutathione synthetase deficiency. Cell Mol Life Sci. 2005;62(17):1938–45.

Article  CAS  Google Scholar 

Mullard A. 2021 FDA approvals. Nat Rev Drug Discov. 2022;21(2):83–8.

Article  CAS  Google Scholar 

Melov S, Tarnopolsky MA, Beckman K, Felkey K, Hubbard A. Resistance exercise reverses aging in human skeletal muscle. PLoS ONE. 2007;2(5):e465.

Article  CAS  Google Scholar 

Phillips BE, Williams JP, Gustafsson T, Bouchard C, Rankinen T, Knudsen S, Smith K, Timmons JA, Atherton PJ. Molecular networks of human muscle adaptation to exercise and age. PLoS Genet. 2013;9(3):e1003389.

Article  CAS  Google Scholar 

留言 (0)

沒有登入
gif