Liu JY, Fu WQ, Zheng XJ, Li W, Ren LW, Wang JH, Yang C, Du GH. Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest. Acta Pharmacol Sin. 2021;42:97-117. https://doi.org/10.1038/s41401-020-0404-8

Harmouch E, Seitlinger J, Chaddad H, Ubeaud-Sequier G, Barths J, Saidu S, Laurent Désaubry L, Grandemange S, Massfelder T, Fuhrmann G, Fioretti F, Dontenwill M, Benkirane-Jessel N, Idoux-Gillet Y. Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes. Sci Rep. 2020;10:13750. https://doi.org/10.1038/s41598-020-70820-6

Sabbagh Q, Andre-Gregoire G, Guevel L, Gavard J. Vesiclemia: counting on extracellular vesicles for glioblastoma patients. Oncogene. 2020;39:6043-6052. https://doi.org/10.1038/s41388-020-01420-x

Avci NG, Ebrahimzadeh-Pustchi S, Akay YM, Esquenazi Y, Tandon N, Zhu JJ, Akay M. NF-κB inhibitor with Temozolomide results in significant apoptosis in glioblastoma via the NF-κB(p65) and actin cytoskeleton regulatory pathways. Sci Rep. 2020;10:1-14. https://doi.org/10.1038/s41598-020-70392-5

Narayanan S, Gupta P, Nazim U, Ali M, Karadkhelkar N, Ahmad M, Chen ZS. Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines. Int J Biochem Cell Biol. 2019;110:21-8. https://doi.org/10.1016/j.biocel.2019.02.004

Zhu Q, Sheng Y, Li W, Wang J, Ma Y, Du B, Tang Y. Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits bladder cancer cell growth via the mitochondrial apoptosis and JNK pathways. Toxicol Appl Pharmacol. 2019;371:41-54. https://doi.org/10.1016/j.taap.2019.03.027

Yang L, Hu Y, Zhou G, Chen Q, Song Z. Erianin suppresses hepatocellular carcinoma cells through down-regulation of PI3K/AKT, p38 and ERK MAPK signaling pathways. Biosci Rep. 2020; 40: BSR20193137 https://doi.org/10.1042/BSR20193137

Li M, He Y, Peng C, Xie X, Hu G. Erianin inhibits human cervical cancer cell through regulation of tumor protein p53 via the extracellular signal-regulated kinase signaling pathway. Oncol Lett. 2018;16:5006-12. https://doi.org/10.3892/ol.2018.9267

Zhang X, Wang Y, Li X, Yang A, Li Z, Wang D. The anti-carcinogenesis properties of erianin in the modulation of oxidative stress-mediated apoptosis and immune response in liver cancer. Aging. 2019;11:10284-300. https://doi.org/10.18632/aging.102456

Wang H, Zhang T, Sun W, Wang Z, Zuo D, Zhou Z, Li S, Xu J, Yin F, Hua Y, Cai Z. Erianin induces G2/M-phase arrest, apoptosis, and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo. Cell Death Dis. 2016;6:e2247. https://doi.org/10.1038/cddis.2016.138

Chen P, Wu Q, Feng J, Yan L, Sun Y, Liu S, Yu Xiang, Zhang M , Pan T, Chen X, Duan T, Zhai L, Zhai B, Wang W, Zhang R, Chen B, Han X, Li Y, Chen L, Liu Y, Huang X, Jin T, Zhang W, Luo H, Chen X, Li Y, Li Q, Li G, Zhang Q, Zhuo L, Yang Z, Tang H, Xie T, Ouyang X, Sui X. Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis. Signal Transduct Target Ther. 2020;5:51. https://doi.org/10.1038/s41392-020-0149-3

Liu YT, Hsieh MJ, Lin JT, Chen G, Lin CC, Lo YS, Chuang YC, Hsi YT, Chen MK, Chou MC. Erianin induces cell apoptosis through ERK pathway in human nasopharyngeal carcinoma. Biomed Pharmacother. 2019;111:262-9. https://doi.org/10.1016/j.biopha.2018.12.081

Sun J, Fu X, Wang Y, Liu Y, Zhang Y, Hao T, Hu X. Erianin inhibits the proliferation of T47D cells by inhibiting cell cycles, inducing apoptosis and suppressing migration. Am J Transl Res. 2016;8:3077-86.

Chen YT, Hsieh MJ, Chen PN, Weng CJ, Yang SF, Lin CW. Erianin Induces Apoptosis and Autophagy in Oral Squamous Cell Carcinoma Cells. Am J Chin Med. 2020;48:183-200. https://doi.org/10.1142/S0192415X2050010X

Zhang Y, Zhang Q, Wei F, Liu N. Progressive study of effects of erianin on anticancer activity. Onco Targets Ther. 2019;12:5457-65. https://doi.org/10.2147/OTT.S200161

Cao Y, Gong Y, Liu L, Zhou Y, Fang X, Zhang C, Li Y, Li J. The use of human umbilical vein endothelial cells (HUVECs) as an in vitro model to assess the toxicity of nanoparticles to endothelium: a review. J Appl Toxicol. 2017;37:1359-69. https://doi.org/10.1002/jat.3470

Gao JJ, Xue X, Gao ZH, Cui SX, Cheng YN, Xu WF, Tang W, Qu XJ. LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo. Microvasc Res. 2011;82:122-30. https://doi.org/10.1016/j.mvr.2011.05.008

Koparal AT. Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid. Z Naturforsch C. 2015;70:159-64. https://doi.org/10.1515/znc-2014-4178

Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene. 2006;25:4798-811. https://doi.org/10.1038/sj.onc.1209608

Degterev A, Boyce M, Yuan J. A decade of caspases. Oncogene. 2003; 22: 8543-67. https://doi.org/10.1038/sj.onc.1207107

Boice A, Bouchier-Hayes L. Targeting apoptotic caspases in cancer. Biochim. Biophys. Acta - Mol. Cell Res. 2020;1867:118688. https://doi.org/10.1016/j.bbamcr.2020.118688

Liu Z, Huang L, Sun L, Nie H, Liang Y, Huang J, Wu F, Hu X. Ecust004 Suppresses Breast Cancer Cell Growth, Invasion, and Migration via EMT Regulation. Drug Des Devel Ther. 2021;15:3451-61. https://doi.org/10.2147/DDDT.S309132

Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 2000;7:1166-73. https://doi.org/10.1038/sj.cdd.4400783

Smaili SS, Hsu TT, Carvalho ACP, Rosenstock TR, Sharpe JC, Youle RJ. Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling. Brazilian J Med Biol Res. 2003;36:183-90. https://doi.org/10.1590/S0100-879X2003000200004

Pijuan J, Barceló C, Moreno DF, Maiques O, Sisó P, Marti RM, Macia A, Panosa A. In vitro cell migration, invasion, and adhesion assays: From cell imaging to data analysis. Front Cell Dev Biol. 2019;7:107. https://doi.org/10.3389/fcell.2019.00107

Sun Y, Li G, Zhou Q, Shao D, Lv J, Zhou J. Dual targeting of cell growth and phagocytosis by erianin for human colorectal cancer. Drug Des Devel Ther. 2020;14:3301-13. https://doi.org/10.2147/DDDT.S259006

Zhang HQ, Xie XF, Li GM, Chen JR, Li MT, Xu X, Xiong QY, Chen GR, Yin YP, Peng F, Chen Y, Peng C. Erianin inhibits human lung cancer cell growth via PI3K/Akt/mTOR pathway in vitro and in vivo. Phytother Res. Phytother Res. 2021;35:4511-25. https://doi.org/10.1002/ptr.7154