Selective Serotonin Reuptake Inhibitors (SSRIs) in Pregnancy: An Updated Review on Risks to Mother, Fetus, and Child

Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T. Perinatal depression: a systematic review of prevalence and incidence. Obstet Gynecol. 2005;106(5 Pt 1):1071–83. https://doi.org/10.1097/01.AOG.0000183597.31630.db.

Article  PubMed  Google Scholar 

Force UPST. Interventions to prevent perinatal depression: US Preventive Services Task Force recommendation statement. JAMA. 2019;321(6):580–7. https://doi.org/10.1001/jama.2019.0007.

Article  Google Scholar 

Molenaar NM, Bais B, Lambregtse-van den Berg MP, Mulder CL, Howell EA, Fox NS, et al. The international prevalence of antidepressant use before, during, and after pregnancy: a systematic review and meta-analysis of timing, type of prescriptions and geographical variability. J Affect Disord. 2020;264:82–9. https://doi.org/10.1016/j.jad.2019.12.014.

Andrade SE, Reichman ME, Mott K, Pitts M, Kieswetter C, Dinatale M, et al. Use of selective serotonin reuptake inhibitors (SSRIs) in women delivering liveborn infants and other women of child-bearing age within the U.S. Food and Drug Administration’s Mini-Sentinel program. Arch Women’s Ment Health. 2016;19(6):969–77. https://doi.org/10.1007/s00737-016-0637-1.

Andrade SE, Raebel MA, Brown J, Lane K, Livingston J, Boudreau D, et al. Use of antidepressant medications during pregnancy: a multisite study. Am J Obstet Gynecol. 2008;198(2):194.e1-5. https://doi.org/10.1016/j.ajog.2007.07.036.

CAS  Article  Google Scholar 

Ornoy A, Koren G. SSRIs and SNRIs (SRI) in pregnancy: effects on the course of pregnancy and the offspring: how far are we from having all the answers? Int J Mol Sci. 2019;20(10). https://doi.org/10.3390/ijms20102370.

Einarson A. The importance of critical evaluation of the literature regarding safety of antidepressant use in pregnancy. Acta Psychiatr Scand. 2013;127(2):115–6. https://doi.org/10.1111/acps.12046.

CAS  Article  PubMed  Google Scholar 

Swanson SA, Hernandez-Diaz S, Palmsten K, Mogun H, Olfson M, Huybrechts KF. Methodological considerations in assessing the effectiveness of antidepressant medication continuation during pregnancy using administrative data. Pharmacoepidemiol Drug Saf. 2015;24(9):934–42. https://doi.org/10.1002/pds.3798.

Article  PubMed  PubMed Central  Google Scholar 

Bérard A, Iessa N, Chaabane S, Muanda FT, Boukhris T, Zhao JP. The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: a systematic review and meta-analysis. Br J Clin Pharmacol. 2016;81(4):589–604. https://doi.org/10.1111/bcp.12849.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bérard A, Ramos E, Rey E, Blais L, St-André M, Oraichi D. First trimester exposure to paroxetine and risk of cardiac malformations in infants: the importance of dosage. Birth Defects Res B Dev Reprod Toxicol. 2007;80(1):18–27. https://doi.org/10.1002/bdrb.20099.

CAS  Article  PubMed  Google Scholar 

Bar-Oz B, Einarson T, Einarson A, Boskovic R, O’Brien L, Malm H, et al. Paroxetine and congenital malformations: meta-analysis and consideration of potential confounding factors. Clin Ther. 2007;29(5):918–26. https://doi.org/10.1016/j.clinthera.2007.05.003.

CAS  Article  PubMed  Google Scholar 

Huybrechts KF, Palmsten K, Avorn J, Cohen LS, Holmes LB, Franklin JM, et al. Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med. 2014;370(25):2397–407. https://doi.org/10.1056/NEJMoa1312828.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Wang S, Yang L, Wang L, Gao L, Xu B, Xiong Y. Selective serotonin reuptake inhibitors (SSRIs) and the risk of congenital heart defects: a meta-analysis of prospective cohort studies. J Am Heart Assoc. 2015;4(5). https://doi.org/10.1161/jaha.114.001681.

•• Anderson KN, Lind JN, Simeone RM, Bobo WV, Mitchell AA, Riehle-Colarusso T, et al. Maternal use of specific antidepressant medications during early pregnancy and the risk of selected birth defects. JAMA Psychiat. 2020;77(12):1246–55. https://doi.org/10.1001/jamapsychiatry.2020.2453. This large case-control study demonstrates that associations between individual SSRIs and congenital heart defects disappear after adjusting for confounding by indication.

Article  Google Scholar 

Wisner KL, Oberlander TF, Huybrechts KF. The association between antidepressant exposure and birth defects—are we there yet? JAMA Psychiat. 2020;77(12):1215–6. https://doi.org/10.1001/jamapsychiatry.2020.1512.

Article  Google Scholar 

De Vries C, Gadzhanova S, Sykes MJ, Ward M, Roughead E. A systematic review and meta-analysis considering the risk for congenital heart defects of antidepressant classes and individual antidepressants. Drug Saf. 2021;44(3):291–312. https://doi.org/10.1007/s40264-020-01027-x.

CAS  Article  PubMed  Google Scholar 

Biffi A, Cantarutti A, Rea F, Locatelli A, Zanini R, Corrao G. Use of antidepressants during pregnancy and neonatal outcomes: an umbrella review of meta-analyses of observational studies. J Psychiatr Res. 2020;124:99–108. https://doi.org/10.1016/j.jpsychires.2020.02.023.

Article  PubMed  Google Scholar 

Melov SJ, Shetty PS, Pasupathy D, Kirby A, Sholler GF, Winlaw DS, et al. Selective serotonin reuptake inhibitor or serotonin-norepinephrine reuptake inhibitors and epidemiological characteristics associated with prenatal diagnosis of congenital heart disease. Prenat Diagn. 2021;41(1):35–42. https://doi.org/10.1002/pd.5846.

CAS  Article  PubMed  Google Scholar 

Gadot Y, Koren G. The use of antidepressants in pregnancy: focus on maternal risks. J Obstet Gynaecol Can. 2015;37(1):56–63. https://doi.org/10.1016/s1701-2163(15)30364-9.

Article  PubMed  Google Scholar 

Toh S, Mitchell AA, Louik C, Werler MM, Chambers CD, Hernández-Díaz S. Selective serotonin reuptake inhibitor use and risk of gestational hypertension. Am J Psychiatry. 2009;166(3):320–8. https://doi.org/10.1176/appi.ajp.2008.08060817.

Article  PubMed  PubMed Central  Google Scholar 

Reis M, Källén B. Delivery outcome after maternal use of antidepressant drugs in pregnancy: an update using Swedish data. Psychol Med. 2010;40(10):1723–33. https://doi.org/10.1017/s0033291709992194.

CAS  Article  PubMed  Google Scholar 

Palmsten K, Hernández-Díaz S, Huybrechts KF, Williams PL, Michels KB, Achtyes ED, et al. Use of antidepressants near delivery and risk of postpartum hemorrhage: cohort study of low income women in the United States. BMJ. 2013;347: f4877. https://doi.org/10.1136/bmj.f4877.

Article  PubMed  PubMed Central  Google Scholar 

Jiang HY, Xu LL, Li YC, Deng M, Peng CT, Ruan B. Antidepressant use during pregnancy and risk of postpartum hemorrhage: a systematic review and meta-analysis. J Psychiatr Res. 2016;83:160–7. https://doi.org/10.1016/j.jpsychires.2016.09.001.

Article  PubMed  Google Scholar 

Lupattelli A, Spigset O, Koren G, Nordeng H. Risk of vaginal bleeding and postpartum hemorrhage after use of antidepressants in pregnancy: a study from the Norwegian Mother and Child Cohort Study. J Clin Psychopharmacol. 2014;34(1):143–8. https://doi.org/10.1097/jcp.0000000000000036.

CAS  Article  PubMed  Google Scholar 

Palmsten K, Huybrechts KF, Michels KB, Williams PL, Mogun H, Setoguchi S, et al. Antidepressant use and risk for preeclampsia. Epidemiology. 2013;24(5):682–91. https://doi.org/10.1097/EDE.0b013e31829e0aaa.

Article  PubMed  PubMed Central  Google Scholar 

Qiu C, Sanchez SE, Lam N, Garcia P, Williams MA. Associations of depression and depressive symptoms with preeclampsia: results from a Peruvian case-control study. BMC Womens Health. 2007;7:15. https://doi.org/10.1186/1472-6874-7-15.

Article  PubMed  PubMed Central  Google Scholar 

Kurki T, Hiilesmaa V, Raitasalo R, Mattila H, Ylikorkala O. Depression and anxiety in early pregnancy and risk for preeclampsia. Obstet Gynecol. 2000;95(4):487–90. https://doi.org/10.1016/s0029-7844(99)00602-x.

CAS  Article  PubMed  Google Scholar 

Laporte S, Chapelle C, Caillet P, Beyens MN, Bellet F, Delavenne X, et al. Bleeding risk under selective serotonin reuptake inhibitor (SSRI) antidepressants: a meta-analysis of observational studies. Pharmacol Res. 2017;118:19–32. https://doi.org/10.1016/j.phrs.2016.08.017.

CAS  Article  PubMed  Google Scholar 

Paton C, Ferrier IN. SSRIs and gastrointestinal bleeding. BMJ. 2005;331(7516):529–30. https://doi.org/10.1136/bmj.331.7516.529.

Article  PubMed  PubMed Central  Google Scholar 

Skalkidou A, Sundström-Poromaa I, Wikman A, Hesselman S, Wikström AK, Elenis E. SSRI use during pregnancy and risk for postpartum haemorrhage: a national register-based cohort study in Sweden. BJOG. 2020;127(11):1366–73. https://doi.org/10.1111/1471-0528.16210.

CAS  Article  PubMed  Google Scholar 

•• Palmsten K, Chambers CD, Wells A, Bandoli G. Patterns of prenatal antidepressant exposure and risk of preeclampsia and postpartum haemorrhage. Paediatr Perinat Epidemiol. 2020;34(5):597–606. https://doi.org/10.1111/ppe.12660. This health claims data study describes a dose-dependent increase in risk of pre-eclampsia and postpartum hemorrhage with perinatal SSRI exposure.

Article  PubMed  PubMed Central  Google Scholar 

Kim DR, Pinheiro E, Luther JF, Eng HF, Dills JL, Wisniewski SR, et al. Is third trimester serotonin reuptake inhibitor use associated with postpartum hemorrhage? J Psychiatr Res. 2016;73:79–85. https://doi.org/10.1016/j.jpsychires.2015.11.005.

Article  PubMed  Google Scholar 

Bixby AL, VandenBerg A, Bostwick JR. Clinical management of bleeding risk with antidepressants. Ann Pharmacother. 2018;53(2):186–94. https://doi.org/10.1177/1060028018794005.

CAS  Article  PubMed  Google Scholar 

Heller HM, Ravelli ACJ, Bruning AHL, de Groot CJM, Scheele F, van Pampus MG, et al. Increased postpartum haemorrhage, the possible relation with serotonergic and other psychopharmacological drugs: a matched cohort study. BMC Pregnancy Childbirth. 2017;17(1):166. https://doi.org/10.1186/s12884-017-1334-4.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bolte AC, van Geijn HP, Dekker GA. Pathophysiology of preeclampsia and the role of serotonin. Eur J Obstet Gynecol Reprod Biol. 2001;95(1):12–21. https://doi.org/10.1016/s0301-2115(00)00367-5.

CAS  Article  PubMed  Google Scholar 

Yaron I, Shirazi I, Judovich R, Levartovsky D, Caspi D, Yaron M. Fluoxetine and amitriptyline inhibit nitric oxide, prostaglandin E2, and hyaluronic acid production in human synovial cells and synovial tissue cultures. Arthritis Rheum. 1999;42(12):2561–8. https://doi.org/10.1002/1529-0131(199912)42:12%3c2561::Aid-anr8%3e3.0.Co;2-u.

CAS  Article  PubMed  Google Scholar 

Finkel MS, Laghrissi-Thode F, Pollock BG, Rong J. Paroxetine is a novel nitric oxide synthase inhibitor. Psychopharmacol Bull. 1996;32(4):653–8.

CAS  PubMed  Google Scholar 

Salvi V, Grua I, Cerveri G, Mencacci C, Barone-Adesi F. The risk of new-onset diabetes in antidepressant users - a systematic review and meta-analysis. PLoS ONE. 2017;12(7): e0182088. https://doi.org/10.1371/journal.pone.0182088.

CAS  Article  PubMed  PubMed Central 

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