Contrast enhanced ultrasound and protein shakes are no alternatives for inulin clearance and meat to assess renal functional reserve in humans
Kidney and Blood Pressure Research
Abstract
Introduction: The measurement of renal functional reserve (RFR) can unmask glomerular hyperfiltration in residual nephrons but its determination is time-consuming. In this study we assessed whether contrast-enhanced ultrasound (CEUS) is a valuable alternative to the gold standard inulin-clearance, and whether L-arginine or protein shakes lead to similar changes in glomerular filtration rate (GFR) as animal proteins in men and women.
Methods: Changes in GFR and renal microperfusion were studied in 25 healthy subjects (8 men, 17 women) by simultaneously performing inulin clearance and CEUS (perfusion index, PI) before and 1 and 2 hours after different protein loads (L-arginine, protein shake or meat). Doppler parameters - renal resistive index (RRI) and pulsatility index (PuI) - were also measured
Results: None of the oral protein loads induced significant changes in CEUS-assessed PI. Only meat increased inulin clearance (from 111.2±16.0 to 149.8±27.2 ml/min, p
The Author(s). Published by S. Karger AG, Basel
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