Arteaga C (2003) Targeting HER1/EGFR: a molecular approach to cancer therapy. Semin Oncol 30(Suppl 7):3–14
CAS PubMed Article Google Scholar
Baselga J (2001) Targeting the epidermal growth factor receptor: a clinical reality. J Clin Oncol 19(Suppl):41S-44S
Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB et al (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354:567–578
CAS PubMed Article Google Scholar
Cohen S, Carpenter G, King L Jr (1980) Epidermal growth factorreceptor- protein kinase interactions: co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity. J Biol Chem 255:4834–4842
CAS PubMed Article Google Scholar
Reimers N, Kasper HU, Weissenborn SJ, Stützer H, Preuss SF, Hoffmann TK et al (2007) Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. Int J Cancer 120(8):1731–1738
CAS PubMed Article Google Scholar
Albitar L, Pickett G, Morgan M, Wilken JA, Maihle NJ, Leslie KK (2010) EGFR isoforms and gene regulation in human endometrial cancer cells. Mol Cancer 9:166
PubMed PubMed Central Article Google Scholar
Mehta A, Chowdhary M, Sinha R (2015) Immunoscoring of epidermal growth factor receptor expression in recurrent cases of oral squamous cell carcinoma. J Oral Pathol Med 44(10):818–822
CAS PubMed Article Google Scholar
Hama T, Yuza Y, Saito Y, O-uchi J, Kondo S, Okabe M et al (2009) Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma. Oncologist 14(9):900–908
CAS PubMed Article Google Scholar
Sessions DG, Spector GJ, Lenox J, Haughey B, Chao C, Marks J (2002) Analysis of treatment results for oral tongue cancer. Laryngoscope 112:616–625
Ayazi B, Saleem K, Azim W, Shaikh A (2011) A clinicopathological study of oral cancers. Biomedica 27:29–32
Chen PH, Shieh TY, Ho PS, Tsai CC, Yang YH, Lin YC et al (2007) Prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan. BMC Cancer 7:101
CAS PubMed PubMed Central Article Google Scholar
Binmadi NO, Basile JR (2011) Perineural invasion in oral squamous cell carcinoma: a discussion of significance and review of the literature. Oral Oncol 47:1005–1010
Rapidis AD, Givalos N, Gakiopoulou H, Faratzis G, Stavrianos SD, Vilos GA et al (2005) Adenoid cystic carcinoma of the head and neck. Clinicopathological analysis of 23 patients and review of the literature. Oral Oncol 41:328–35
Nair D, Mair M, Singhvi H, Mishra A, Nair S, Agrawal J, Chaturvedi P (2018) Perineural invasion: independent prognostic factor in oral cancer that warrants adjuvant treatment. Head Neck 40(8):1780–1787
Adel M, Kao HK, Hsu CL, Huang JJ, Lee LY, Huang Y, Browne T et al (2015) Evaluation of lymphatic and vascular invasion in relation to clinicopathological factors and treatment outcome in oral cavity squamous cell carcinoma. Medicine 94(43):e1510
PubMed PubMed Central Article Google Scholar
Jakobsson PÅ, Eneroth CM, Killander D, Moberger G, Mårtensson B (1973) Histologic classification and grading of malignancy in carcinoma of the larynx. Acta Radiol Ther Phys Biol 12(1):1–8
CAS PubMed Article Google Scholar
Jones HB, Sykes A, Bayman N, Sloan P, Swindell R, Patel M, Musgrove B (2009) The impact of lymphovascular invasion on survival in oral carcinoma. Oral Oncol 45(1):10–15
CAS PubMed Article Google Scholar
Oliveira LR, Ribeiro-Silva A (2011) Prognostic significance of immunohistochemical biomarkers in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 40(3):298–307
CAS PubMed Article Google Scholar
Sarkis SA, Abdullah BH, Majeed BA, Talabani NG (2010) Immunohistochemical expression of epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma in relation to proliferation, apoptosis, angiogenesis and lymphangiogenesis. Head Neck Oncol 2(1):1–8
Baba Y, Fujii M, Tokumaru Y, Kato Y (2012) Present and future of EGFR inhibitors for head and neck squamous cell cancer. J Oncol 1:2012
Rahima B, Shingaki S, Nagata M, Saito C (2004) Prognostic significance of perineural invasion in oral and oropharyngeal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 97(4):423–431
Zanotti L, Paderno A, Piazza C, Pagan E, Bignotti E, Romani C et al (2017) Epidermal growth factor receptor detection in serum and saliva as a diagnostic and prognostic tool in oral cancer. Laryngoscope 127(11):E408–E414
CAS PubMed Article Google Scholar
Hashmi AA, Hussain ZF, Aijaz S, Irfan M, Khan EY, Naz S et al (2018) Immunohistochemical expression of epidermal growth factor receptor (EGFR) in South Asian head and neck squamous cell carcinoma: association with various risk factors and clinico-pathologic and prognostic parameters. World J Surg Oncol 16(1):1–9
PubMed PubMed Central Article Google Scholar
Akheel M, George RK, Jain A, Chahwala Q, Wadhwania A (2019) Surgical margins and nodal metastasis are prognostic factors in oral squamous cell carcinoma: a meta-analysis. Clin Cancer Investig J 8(2):47
Brandwein-Gensler M, Teixeira MS, Lewis CM, Lee B, Rolnitzky L, Hille JJ et al (2005) Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol 29(2):167–178
Srinivasan M, Jewell SD (2001) Evaluation of TGF-α and EGFR expression in oral leukoplakia and oral submucous fibrosis by quantitative immunohistochemistry. Oncology 61(4):284–292
CAS PubMed Article Google Scholar
Ang KK, Berkey BA, Tu X, Zhang HZ, Katz R, Hammond EH, Fu KK, Milas L (2002) Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Can Res 62(24):7350–7356
Lee JW, Soung YH, Kim SY, Nam HK, Park WS, Nam SW et al (2005) Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck. Clin Cancer Res 11(8):2879–2882
CAS PubMed Article Google Scholar
Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N et al (2006) Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol 24(25):4170–4176
CAS PubMed Article Google Scholar
Loree TR, Strong EW (1990) Significance of positive margins in oral cavity squamous carcinoma. Am J Surg 160(4):410–414
CAS PubMed Article Google Scholar
Mistry RC, Qureshi SS, Kumaran C (2005) Post-resection mucosal margin shrinkage in oral cancer: quantification and significance. J Surg Oncol 91(2):131–133
Cheng A, Cox D, Schmidt BL (2008) Oral squamous cell carcinoma margin discrepancy after resection and pathologic processing. J Oral Maxillofac Surg 66(3):523–529
Helliwell T, Woolgar J (2011) Dataset for histopathology reporting of mucosal malignancies of the oral cavity. Royal College of Pathologists, London
Keski-Säntti H, Atula T, Törnwall J, Koivunen P, Mäkitie A (2006) Elective neck treatment versus observation in patients with T1/T2 N0 squamous cell carcinoma of oral tongue. Oral Oncol 42(1):95–100
Melchers LJ, Schuuring E, van Dijk BA, De Bock GH, Witjes MJ, Van der Laan BF et al (2012) Tumour infiltration depth⩾ 4 mm is an indication for an elective neck dissection in pT1cN0 oral squamous cell carcinoma. Oral Oncol 48(4):337–42
CAS PubMed Article Google Scholar
Balasubramanian D, Ebrahimi A, Gupta R, Gao K, Elliott M, Palme CE, Clark JR (2014) Tumour thickness as a predictor of nodal metastases in oral cancer: comparison between tongue and floor of mouth subsites. Oral Oncol 50(12):1165–1168
Süslü N, Hoşal AŞ, Aslan T, Sözeri B, Dolgun A (2013) Carcinoma of the oral tongue: a case series analysis of prognostic factors and surgical outcomes. J Oral Maxillofac Surg 71(7):1283–1290
Nuratna IN, Wisesa IB (2016) Association of Epidermal Growth Factor Receptor (EGFR) with tumor location and clinicopathological aspect in head and neck squamous cell carcinoma. Bali Med J 5(2):283–289
Taberna M, Torres M, Alejo M, Mena M, Tous S, Marquez S, Pavón MA, León X, García J, Guix M, Hijano R, Bonfill T, Aguilà A, Lozano A, Mesía R, Alemany L, Bravo IG (2018) The use of HPV16-E5, EGFR, and pEGFR as prognostic biomarkers for oropharyngeal cancer patients. Front Oncol 11(8):589. https://doi.org/10.3389/fonc.2018.00589 (PMID:30619735;PMCID:PMC6297752.YenTC)
Kaur G, Phogat D, Manu V (2021) Study of EGFR mutations in head and neck squamous cell carcinomas. Autops Case Rep 19:11
Liao CT, Chang JT, Wang HM, Ng SH, Hsueh C, Lee LY, Lin CH, Chen IH, Huang SF, Cheng AJ, Yen TC (2008) Analysis of risk factors of predictive local tumor control in oral cavity cancer. Ann Surg Oncol 15(3):915–22
留言 (0)