Supported by the Core Research for Evolutional Science and Technology (JPMJCR17H3), the Japan Society for the Promotion of Science KAKENHI (18K15948 and 20K21599), and The Japanese Respiratory Society Research Grants Program 2021 by Boehringer Ingelheim.

Author Contributions: Concept and design: A.S., K.S., Y.N., and N.H. Data acquisition: A.S., K.S., Y.N., A.A., M.I., Y.S., N.O., M.K., J.F., and N.H. Analysis and interpretation; A.S., K.S., Y.N., A.E., J.H., Y.S., and N.H. Drafting the manuscript: A.S., K.S., and N.H. Revising the manuscript: all authors. Final approval of the manuscript: all authors.