A Unique CD27-IgD- B Cell Population in the Sputum of Severe Eosinophilic Asthma Associated with Airway Autoimmunity

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"A Unique CD27-IgD- B Cell Population in the Sputum of Severe Eosinophilic Asthma Associated with Airway Autoimmunity." American Journal of Respiratory Cell and Molecular Biology, 67(4), pp. 506–511

Ethical approval of the project was provided by the National Healthcare Group Domain Specific Review Board (Ref. 2018/00910). All subjects gave written informed consent.

Supported by grants from the National Research Foundation, under its Campus for Research Excellence and Technological Enterprise (CREATE) and National Medical Research Council (Project ID: MOH-000146-01).

Author Contributions: H.F.L. and V.A. conceived the idea and take responsibility for the overall guarantee of the paper. N.S.T. and M.M. developed the experimental design and wrote the first draft of the manuscript. S.Y.L. and C.H.T. were involved in flow cytometry and protein assay analysis. A.R. and K.F. participated in the development of ELISpot. Y.Y.H. and A.L. were involved in the planning and acquisition of a multiparametric flow cytometry panel. W.S.D.T., W.L., and W.S.F.W. performed the multiplex assay and PBMC processing. N.S.T., M.F.L., and H.F.L. participated in patient care, recruitment, and coordination. M.M., P.N., and D.Y.W. provided scientific advice. H.F.L., V.A., and N.S.T. analyzed data. All authors have read and consented to the final manuscript draft.

This letter has a data supplement, which is accessible from this issue’s table of contents online at www.atsjournals.org.

Author disclosures are available with the text of this letter at www.atsjournals.org.

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