Abaci A, Catli G, Anik A et al (2013) The relation of serum nesfatin-1 level with metabolic and clinical parameters in obese and healthy children. Pediatr Diabetes 14:189–195

CAS  PubMed  Google Scholar 

Akinci A, Cetin D, Ilhan N (2012) Plasma kisspeptin levels in girls with premature thelarche. J Clin Res Pediatr Endocrinol 4:61–65

PubMed  PubMed Central  Article  Google Scholar 

Altıncık A, Sayın O (2018) Serum Nesfatin-1 levels in girls with idiopathic central precocious puberty. J Clin Res Pediatr Endocrinol 10:8

PubMed  PubMed Central  Article  Google Scholar 

Anthroplus Who (2007) growth reference 5–19 years. Geneva: WHO

Anwar GM, Yamamah G, Ibrahim A et al (2014) Nesfatin-1 in childhood and adolescent obesity and its association with food intake, body composition and insulin resistance. Regul Pept 188:21–24

CAS  PubMed  Article  Google Scholar 

Ayada C, Toru Ü, Korkut Y (2015) Nesfatin-1 and its effects on different systems. Hippokratia 19:4–10

CAS  PubMed  PubMed Central  Google Scholar 

Barreiro M, Tena-Sempere M (2004) Ghrelin and reproduction: a novel signal linking energy status and fertility? Mol Cell Endocrinol 226:1–9

CAS  PubMed  Article  Google Scholar 

Bellone S, Rapa A, Vivenza D et al (2002) Circulating ghrelin levels as function of gender, pubertal status and adiposity in childhood. J Endocrinol Invest 25:RC13–RC15

CAS  PubMed  Article  Google Scholar 

Biro FM, Greenspan LC, Galvez MP et al (2013) Onset of breast development in a longitudinal cohort. Pediatrics 132:1019–1027

PubMed  PubMed Central  Article  Google Scholar 

Blum WF, Englaro P, Hanitsch S et al (1997) Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab 82:2904–2910

CAS  PubMed  Google Scholar 

Brix N, Ernst A, Lauridsen LLB et al (2020) Childhood overweight and obesity and timing of puberty in boys and girls: cohort and sibling-matched analyses. Int J Epidemiol 49:834–844

PubMed  PubMed Central  Article  Google Scholar 

Budak E, Fernandez Sanchez M, Bellver J et al (2006) Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertil Steril 85:1563–1581

CAS  PubMed  Article  Google Scholar 

Catli G, Anik A, Kume T et al (2015) Serum nesfatin-1 and leptin levels in non-obese girls with premature thelarche. J Endocrinol Invest 38:909–913

CAS  PubMed  Article  Google Scholar 

Chehab FF, Mounzih K, Lu R et al (1997) Early onset of reproductive function in normal female mice treated with leptin. Science 275:88–90

CAS  PubMed  Article  Google Scholar 

Cheng HL, Sainsbury A, Garden F et al (2018) Ghrelin and peptide YY change during puberty: relationships with adolescent growth, development, and obesity. J Clin Endocrinol Metab 103:2851–2860

PubMed  Article  Google Scholar 

Dundar B, Pirgon O, Sangun O et al (2013) Elevated leptin levels in nonobese girls with premature thelarche. J Investig Med 61:984–988

CAS  PubMed  Article  Google Scholar 

Durmaz E, Asci A, Erkekoglu P et al (2018) Urinary bisphenol A levels in Turkish girls with premature thelarche. Hum Exp Toxicol 37:1007–1016

CAS  PubMed  Article  Google Scholar 

Eckert-Lind C, Busch AS, Petersen JH et al (2020) Worldwide secular trends in age at pubertal onset assessed by breast development among girls: a systematic review and meta-analysis. JAMA Pediatr 174:e195881–e195881

PubMed  PubMed Central  Article  Google Scholar 

El-Eshmawy MM, Abdel Aal IA, El Hawary AK (2010) Association of ghrelin and leptin with reproductive hormones in constitutional delay of growth and puberty. Reprod Biol Endocrinol 8:153–153

CAS  PubMed  PubMed Central  Article  Google Scholar 

Fernandez-Fernandez R, Martini A, Navarro V et al (2006) Novel signals for the integration of energy balance and reproduction. Mol Cell Endocrinol 254:127–132

PubMed  Article  Google Scholar 

Furuta M, Funabashi T, Kimura F (2002) Suppressive action of orexin A on pulsatile luteinizing hormone secretion is potentiated by a low dose of estrogen in ovariectomized rats. Neuroendocrinology 75:151–157

CAS  PubMed  Article  Google Scholar 

García-Galiano D, Pineda R, Ilhan T et al (2012) Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis. Endocrinology 153:1959–1971

PubMed  Article  Google Scholar 

García-Galiano D, Tena-Sempere M (2013) Emerging roles of NUCB2/nesfatin-1 in the metabolic control of reproduction. Curr Pharm Des 19:6966–6972

PubMed  Article  Google Scholar 

Gavela-Pérez T, Navarro P, Soriano-Guillén L et al (2016) High prepubertal leptin levels are associated with earlier menarcheal age. J Adolesc Health 59:177–181

PubMed  Article  Google Scholar 

Goforth PB, Myers MG (2017) Roles for orexin/hypocretin in the control of energy balance and metabolism. In: Lawrence AJ, de Lecea L (eds) Behavioral Neuroscience of orexin/hypocretin. Springer, Cham, pp 137–156

Google Scholar 

He F, Guan P, Liu Q et al (2017) The relationship between obesity and body compositions with respect to the timing of puberty in Chongqing adolescents: a cross-sectional study. BMC Public Health 17:664

PubMed  PubMed Central  Article  Google Scholar 

Iqbal J, Pompolo S, Sakurai T et al (2001) Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus. J Neuroendocrinol 13:1033–1041

CAS  PubMed  Article  Google Scholar 

Isse A, Tao Y-H, Naji W et al (2017) Role of orexin in reproductive system. J Dent Sci 16:122–124

Google Scholar 

Kawamura K, Sato N, Fukuda J et al (2003) Ghrelin inhibits the development of mouse preimplantation embryos in vitro. Endocrinology 144:2623–2633

CAS  PubMed  Article  Google Scholar 

Kelly Y, Zilanawala A, Sacker A et al (2017) Early puberty in 11-year-old girls: millennium cohort study findings. Arch Dis Child 102:232–237

PubMed  Article  Google Scholar 

Kohsaka A, Watanobe H, Kakizaki Y et al (2001) A significant participation of orexin-A, a potent orexigenic peptide, in the preovulatory luteinizing hormone and prolactin surges in the rat. Brain Res 898:166–170

CAS  PubMed  Article  Google Scholar 

Kurnaz E, Şen Y, Aydın S (2017) Plasma kisspeptin and ghrelin levels in puberty variant cases. J Pediatr Endocrinol Metab 30:569–573

CAS  PubMed  Article  Google Scholar 

Lian Q, Mao Y, Luo S et al (2019) Puberty timing associated with obesity and central obesity in Chinese Han girls. BMC Pediatr 19:1

PubMed  PubMed Central  Article  Google Scholar 

Marshall WA, Tanner JM (1969) Variations in pattern of pubertal changes in girls. Arch Dis Child 44:291

CAS  PubMed  PubMed Central  Article  Google Scholar 

Matkovic V, Ilich JZ, Skugor M et al (1997) Leptin is inversely related to age at menarche in human females*. J Clin Endocrinol Metab 82:3239–3245

CAS  PubMed  Google Scholar 

Matzeu A, Martin-Fardon R (2022) Understanding the role of orexin neuropeptides in drug addiction: preclinical studies and translational value. Front Behav Neurosci 15:787595

PubMed  PubMed Central  Article  Google Scholar 

Moschos S, Chan JL, Mantzoros CS (2002) Leptin and reproduction: a review. Fertil Steril 77:433–444

PubMed  Article  Google Scholar 

Pasquino A, Piccolo F, Scalamandre A et al (1980) Hypothalamic-pituitary-gonadotropic function in girls with premature thelarche. Arch Dis Child 55:941–944

CAS  PubMed  PubMed Central  Article  Google Scholar 

Pu S, Jain MR, Kalra PS et al (1998) Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Regul Pept 78:133

CAS  PubMed  Google Scholar 

Rosati S, Maarouf R, Brown K et al (2015) Histrelin for central precocious puberty—a single surgeon experience. J Surg Res 198:355–359

CAS  PubMed  Article  Google Scholar 

Şahin Z (2015) Experimental Studies on the Interaction of Kisspeptin, Rfrp-3 and Nesfatin-1 in Neuroendocrine Regulation of Puberty and Reproduction. In:Fırat University, Institute of Health Sciences, Medicine Program, Department of Physiology, Elazığ

Sasson R, Dearth RK, White RS et al (2006) Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons. Neuroendocrinology 84:353–363

CAS  PubMed