Enhanced anxiolytic and analgesic effectiveness or a better safety profile of morphine and tramadol combination in cholestatic and addicted mice

aCognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University

bDepartment of Pharmacology School of Medicine, Tehran University of Medical Sciences

cIranian National Center for Addiction Studies, Tehran University of Medical Sciences

dDepartment of Neuroendocrinology, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Received 6 August 2022 Accepted 18 August 2022

Correspondence to Prof. Mohammad-Reza Zarrindast, Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, P.O.Box: 13145-784, Tehran, Iran, Tel/fax: +9821 66402569; e-mail: [email protected]

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