Flemming W (1965) Contributions to the knowledge of the cell and its vital processes. J Cell Biol 25(1):3–69

CAS  Article  Google Scholar 

Bischoff M, Parfitt DE, Zernicka-Goetz M (2008) Formation of the embryonic-abembryonic axis of the mouse blastocyst: relationships between orientation of early cleavage divisions and pattern of symmetric/asymmetric divisions. Development 135(5):953–962. https://doi.org/10.1242/dev.014316

CAS  Article  PubMed  Google Scholar 

Piotrowska-Nitsche K, Zernicka-Goetz M (2005) Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryo. Mech Dev 122(4):487–500. https://doi.org/10.1016/j.mod.2004.11.014

CAS  Article  PubMed  Google Scholar 

Tabansky I, Lenarcic A, Draft RW, Loulier K, Keskin DB, Rosains J, Rivera-Feliciano J, Lichtman JW et al (2013) Developmental bias in cleavage-stage mouse blastomeres. Curr Biol 23(1):21–31. https://doi.org/10.1016/j.cub.2012.10.054

CAS  Article  PubMed  Google Scholar 

Burton A, Muller J, Tu S, Padilla-Longoria P, Guccione E, Torres-Padilla ME (2013) Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Cell Rep 5(3):687–701. https://doi.org/10.1016/j.celrep.2013.09.044

CAS  Article  PubMed  Google Scholar 

Plachta N, Bollenbach T, Pease S, Fraser SE, Pantazis P (2011) Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nat Cell Biol 13(2):117–123. https://doi.org/10.1038/ncb2154

CAS  Article  PubMed  Google Scholar 

Torres-Padilla ME, Parfitt DE, Kouzarides T, Zernicka-Goetz M (2007) Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature 445(7124):214–218. https://doi.org/10.1038/nature05458

CAS  Article  PubMed  PubMed Central  Google Scholar 

Conklin EG (1905) Mosaic development in ascidian eggs. J Exp Zool 2(2):145–223. https://doi.org/10.1002/jez.1400020202

Article  Google Scholar 

Keller GM (1995) In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol 7(6):862–869. https://doi.org/10.1016/0955-0674(95)80071-9

CAS  Article  PubMed  Google Scholar 

Surani MA, Hayashi K, Hajkova P (2007) Genetic and epigenetic regulators of pluripotency. Cell 128(4):747–762. https://doi.org/10.1016/j.cell.2007.02.010

CAS  Article  PubMed  Google Scholar 

Dhara SK, Stice SL (2008) Neural differentiation of human embryonic stem cells. J Cell Biochem 105(3):633–640. https://doi.org/10.1002/jcb.21891

CAS  Article  PubMed  PubMed Central  Google Scholar 

Mukherjee S, Kong J, Brat DJ (2015) Cancer stem cell division: when the rules of asymmetry are broken. Stem Cells Dev 24(4):405–416. https://doi.org/10.1089/scd.2014.0442

Article  PubMed  Google Scholar 

Lewis KM, Petritsch C (2013) Asymmetric cell division: implications for glioma development and treatment. Transl Neurosci 4(4):484–503. https://doi.org/10.2478/s13380-013-0148-8

Article  PubMed  Google Scholar 

Lim S, Kaldis P (2013) Cdks, cyclins and CKIs: roles beyond cell cycle regulation. Dev 140(15):3079–3093. https://doi.org/10.1242/dev.091744

CAS  Article  Google Scholar 

He S, Nakada D, Morrison SJ (2009) Mechanisms of stem cell self-renewal. Annu Rev Cell Dev Biol 25:377–406. https://doi.org/10.1146/annurev.cellbio.042308.113248

CAS  Article  PubMed  Google Scholar 

Silva-Vargas V, Delgado AC, Doetsch F (2018) Symmetric Stem Cell Division at the Heart of Adult Neurogenesis. Neuron 98(2):246–248. https://doi.org/10.1016/j.neuron.2018.04.005

CAS  Article  PubMed  Google Scholar 

Beach D, Durkacz B, Nurse P (1982) Functionally homologous cell cycle control genes in budding and fission yeast. Nature 300(5894):706–709. https://doi.org/10.1038/300706a0

CAS  Article  PubMed  Google Scholar 

Evans T, Rosenthal ET, Youngblom J, Distel D, Hunt T (1983) Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 33(2):389–396. https://doi.org/10.1016/0092-8674(83)90420-8

CAS  Article  PubMed  Google Scholar 

Nurse P, Thuriaux P (1980) Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe. Genetics 96(3):627–637

CAS  Article  Google Scholar 

Nurse P, Thuriaux P, Nasmyth K (1976) Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe. Mol Gen Genet 146(2):167–178. https://doi.org/10.1007/BF00268085

CAS  Article  PubMed  Google Scholar 

Reed SI, Ferguson J, Groppe JC (1982) Preliminary characterization of the transcriptional and translational products of the Saccharomyces cerevisiae cell division cycle gene CDC28. Mol Cell Biol 2(4):412–425. https://doi.org/10.1128/mcb.2.4.412

CAS  Article  PubMed  PubMed Central  Google Scholar 

Sherr CJ (1994) G1 phase progression: cycling on cue. Cell 79(4):551–555. https://doi.org/10.1016/0092-8674(94)90540-1

CAS  Article  PubMed  Google Scholar 

Sherr CJ (1996) Cancer cell cycles. Sci 274(5293):1672–1677. https://doi.org/10.1126/science.274.5293.1672

CAS  Article  Google Scholar 

Pavletich NP (1999) Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors. J Mol Biol 287(5):821–828. https://doi.org/10.1006/jmbi.1999.2640

CAS  Article  PubMed  Google Scholar 

Shah K, Lahiri DK (2014) Cdk5 activity in the brain - multiple paths of regulation. J Cell Sci 127(Pt 11):2391–2400. https://doi.org/10.1242/jcs.147553

CAS  Article  PubMed  PubMed Central  Google Scholar 

Lagace DC, Benavides DR, Kansy JW, Mapelli M, Greengard P, Bibb JA, Eisch AJ (2008) Cdk5 is essential for adult hippocampal neurogenesis. Proc Natl Acad Sci U S A 105(47):18567–18571. https://doi.org/10.1073/pnas.0810137105

Article  PubMed  PubMed Central  Google Scholar 

Shupp A, Casimiro MC, Pestell RG (2017) Biological functions of CDK5 and potential CDK5 targeted clinical treatments. Oncotarget 8(10):17373–17382. https://doi.org/10.18632/oncotarget.14538

Article  PubMed  PubMed Central  Google Scholar 

Lew J, Beaudette K, Litwin CM, Wang JH (1992) Purification and characterization of a novel proline-directed protein kinase from bovine brain. J Biol Chem 267(19):13383–13390. https://doi.org/10.1016/S0021-9258(18)42222-3

CAS  Article  PubMed  Google Scholar 

Wang X, Tsai JW, Imai JH, Lian WN, Vallee RB, Shi SH (2009) Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature 461(7266):947–955. https://doi.org/10.1038/nature08435

CAS  Article  PubMed  PubMed Central  Google Scholar 

Costa MR, Wen G, Lepier A, Schroeder T, Gotz M (2008) Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex. Dev 135(1):11–22. https://doi.org/10.1242/dev.009951

CAS  Article  Google Scholar 

Morales AV, Mira H (2019) Adult Neural Stem Cells: Born to Last. Front Cell Dev Biol 7:96. https://doi.org/10.3389/fcell.2019.00096

Article  PubMed  PubMed Central  Google Scholar 

Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J et al (2011) Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell 20(3):328–340. https://doi.org/10.1016/j.ccr.2011.08.011

CAS  Article  PubMed  PubMed Central  Google Scholar 

Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK et al (2021) The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol 23(8):1231–1251. https://doi.org/10.1093/neuonc/noab106

CAS  Article  PubMed  PubMed Central  Google Scholar 

Beck B, Blanpain C (2013) Unravelling cancer stem cell potential. Nat Rev Cancer 13(10):727–738. https://doi.org/10.1038/nrc3597

CAS  Article  PubMed  Google Scholar 

Hitomi M, Chumakova AP, Silver DJ, Knudsen AM, Pontius WD, Murphy S, Anand N, Kristensen BW et al (2021) Asymmetric cell division promotes therapeutic resistance in glioblastoma stem cells. JCI Insight 6 (3). https://doi.org/10.1172/jci.insight.130510

Lathia JD, Hitomi M, Gallagher J, Gadani SP, Adkins J, Vasanji A, Liu L, Eyler CE et al (2011) Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions. Cell Death Dis 2:e200. https://doi.org/10.1038/cddis.2011.80

CAS  Article  PubMed  PubMed Central  Google Scholar 

Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414(6859):105–111. https://doi.org/10.1038/35102167

CAS  Article  PubMed  Google Scholar 

Xiang H, Yuan L, Gao X, Alexander PB, Lopez O, Lau C, Ding Y, Chong M et al (2017) UHRF1 is required for basal stem cell proliferation in response to airway injury. Cell Discov 3:17019. https://doi.org/10.1038/celldisc.2017.19