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Research Article
Wu W.a,b· Zheng X.baInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, China
bDepartment of Public Health and Preventive Medicine, Wuxi School of Medicine Jiangnan University, Wuxi, China
Xiaowei Zheng, zxw19921212@163.com
AbstractIntroduction: Previous studies had reported the impact of weight changes in middle age on the incidence of cardiovascular disease (CVD), but the results were inconsistent. In present study, we aimed to investigate the impact of a 4-year weight change on the risk of CVD in middle-aged and elderly Chinese individuals. Methods: Using nationally representative data from the China Health and Retirement Longitudinal Study, 7,530 participants (age: 58.2 ± 8.9 years) were included. Weight change was calculated by subtracting weight at baseline from that at 4-year follow-up. Weight change over 4 years was divided into 5 categories (loss ≥5 kg; loss 2–5 kg; stable (change ≤2 kg); gain 2–5 kg; and gain ≥5 kg). Results: During the follow-up period, a total of 758 respondents experienced CVD (including 319 stroke and 477 cardiac events). The multivariable ORs of CVD for gain ≥5 kg compared to stable weight (change ≤2 kg) was 1.50 (95% CI, 1.14–1.97) versus 1.41(1.09–1.83) for losing ≥5 kg. Multivariable-adjusted logistic regression model with restricted cubic splines showed a U-shaped association between weight change and the risk of CVD (p for nonlinearity <0.001). The significant associations did not change in subgroup and sensitivity analysis. Weight change was also associated with higher risk of stroke and cardiac events. Conclusion: Weight changes (weight gain or loss more than 5 kg) during middle age were associated with an increased risk of CVD in middle-aged and elderly Chinese individuals.
© 2022 The Author(s). Published by S. Karger AG, Basel
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Received: April 22, 2022
Accepted: August 04, 2022
Published online: August 25, 2022
Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 4
ISSN: 1662-4025 (Print)
eISSN: 1662-4033 (Online)
For additional information: https://www.karger.com/OFA
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