Significance of fermented rice beverage on management of antibiotic associated diarrhea (AAD) on Wistar rats

Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/60574

metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v60i10.37145Title: Significance of fermented rice beverage on management of antibiotic associated diarrhea (AAD) on Wistar ratsAuthors: Mishra, Birendra Kumar
Das, Sujit
Prajapati, Jashbhai B.
Patel, Maulik
Ghodasara, Dineshkumar J.
Pathan, Mohsinkhan
Hati, SubrotaKeywords: Cecum;Chubitchi;Colon;SCFAs;Garo Hills;Goatweed;Gut microflora;Heaptoprotective;Licorice weed;Liver;Menil;Sweet-broom;Traditional foodIssue Date: Sep-2022Publisher: NIScPR-CSIR, IndiaAbstract: Antibiotic associated diarrhoea (AAD) is caused mostly by disruption of the physiological gut microflora. One potential strategy to prevent this is the concurrent use of probiotic bacteria or yeast. Tribal populations of West Garo Hill region of Meghalaya use locally available unique microflora to prepare fermented food products whichserve as a potential source of novel probiotic organisms and bioactive compounds. In this context, here, we have evaluated the potentiality of laboratory made functional fermented rice beverage in mitigating AAD on animal models viz. Wistar rats. The animal models were administered with fermented rice beverage (test group A1), combination of indigenous Lactobacillus isolates (test group A2), a yeast isolate (test group A3), loperamide (test group STD), normal control (test group NC) and disease control (test group DC). Furthermore, various diarrhea assessment parameters were checked from each group followed by analysis of fecal microbiome, haematological parameters, histopathology of colon, liver and cecal short chain fatty acids (SCFAs) determination. NC and A1 was least affected by AAD induction with a faecal consistency score of 1 on the final day of the study. After day 10, a significant reduction (P Page(s): 759-770ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:IJEB Vol.60(10) [Oct 2022]

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