Editorial overview: Protein–carbohydrate complexes and glycosylation

Joseph Zaia's research group focusses on analytical biochemistry of glycoproteins and proteoglycans. They have developed methods for combined glycomics, proteomics and glycoproteomics from tissue slides. They have produced a set of bioinformatics tools for interpretation of mass spectrometry-based glycomics and glycoproteomics data sets. Their major goals are to track changes in protein glycosylation during biological mechanisms. Specific projects include (i) mapping changes in extracellular matrix protein glycosylation during brain disease mechanisms and (ii) analysis of the roles of viral spike protein glycosylation in evolution of pathogenic enveloped viruses. Dr. Zaia has published more than 150 articles in peer reviewed scientific journals and has an H-index of 54. He is an editor of Analytical and Bioanalytical Chemistry.

Sylvie Ricard-Blum earned her PhD in Biochemistry in 1986 from the University of Lyon (France). Then she worked in Pasteur Institute (Lyon), where she became a Principal Investigator (PI), moved to the Institute of Structural Biology (Grenoble) in 1998, and became Professor of Biochemistry at the University of Lyon in 2004. Her work, combining biochemistry, biophysics, and bioinformatics, aims at studying the structure–interaction–function relationships of the extracellular matrix, with a focus on intrinsically disordered proteins and proteoglycans. Her team has identified hundreds of interactions, built numerous interactomes including those of glycosaminoglycans, and created the interaction database MatrixDB.

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