We herein describe a nickel-catalyzed cyanation reaction of aryl/alkenyl halides with alkyl isocyanides. Both aryl/alkenyl iodines and bromides are competent electrophiles that react with alkyl isocyanides, affording nitrile compounds in moderate to good yields. A range of functional groups such as halogens, hydroxyl, formyl, acetamino are fairly compatible to the nickel catalysis. This protocol features broad functional group tolerance, simple reaction conditions, and gram-scale synthesis.

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