Endogenous Adenosine 5′-Monophosphate, But Not Acetylcholine or Histamine, is Associated with Asthma Control, Quality of Life, and Exacerbations

Masoli M, Fabian D, Holt S et al (2004) The global burden of asthma: executive summary of the GINA dissemination committee report. Allergy 59(5):469–478. https://doi.org/10.1111/j.1398-9995.2004.00526.x

Article  PubMed  Google Scholar 

Stern J, Pier J, Litonjua AA (2020) Asthma epidemiology and risk factors. Semin Immunopathol 42(1):5–15. https://doi.org/10.1007/s00281-020-00785-1

Article  PubMed  Google Scholar 

Global Initiative for Asthma (2020) Global Strategy for Asthma Management and Prevention www.ginasthma.org

Hallstrand TS, Leuppi JD, Joos G et al (2018) ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing. Eur Respir J 52(5):1801033. https://doi.org/10.1183/13993003.01033-2018

CAS  Article  PubMed  Google Scholar 

Kistemaker LE, Gosens R (2015) Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling. Trends Pharmacol Sci 36(3):164–171. https://doi.org/10.1016/j.tips.2014.11.005

CAS  Article  PubMed  Google Scholar 

Gori S, Vermeulen M, Remes-Lenicov F et al (2017) Acetylcholine polarizes dendritic cells toward a Th2-promoting profile. Allergy 72(2):221–231. https://doi.org/10.1111/all.12926

CAS  Article  PubMed  Google Scholar 

Dunford PJ, Holgate ST (2010) The role of histamine in asthma. Adv Exp Med Biol 709:53–66. https://doi.org/10.1007/978-1-4419-8056-4_6

CAS  Article  PubMed  Google Scholar 

van den Berge M, Polosa R, Kerstjens HA et al (2004) The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol 114(4):737–746. https://doi.org/10.1016/j.jaci.2004.05.071

CAS  Article  PubMed  Google Scholar 

Taylor DA, Jensen MW, Kanabar V et al (1999) A dose-dependent effect of the novel inhaled corticosteroid ciclesonide on airway responsiveness to adenosine-5′-monophosphate in asthmatic patients. Am J Respir Crit Care Med 160(1):237–243. https://doi.org/10.1164/ajrccm.160.1.9809046

CAS  Article  PubMed  Google Scholar 

Cockcroft DW (2010) Direct challenge tests: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 138(2 Suppl):18s–24s. https://doi.org/10.1378/chest.10-0088

CAS  Article  PubMed  Google Scholar 

Tsurikisawa N, Oshikata C, Tsuburai T et al (2010) Bronchial reactivity to histamine is correlated with airway remodeling in adults with moderate to severe asthma. J Asthma 47(8):841–848. https://doi.org/10.3109/02770903.2010.504876

CAS  Article  PubMed  Google Scholar 

Kim CK, Hagan JB (2004) Sputum tests in the diagnosis and monitoring of asthma. Ann Allergy Asthma Immunol 93(2):112–122. https://doi.org/10.1016/s1081-1206(10)61462-7

Article  PubMed  Google Scholar 

Nathan RA, Sorkness CA, Kosinski M et al (2004) Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 113(1):59–65. https://doi.org/10.1016/j.jaci.2003.09.008

Article  PubMed  Google Scholar 

Juniper EF, Norman GR, Cox FM et al (2001) Comparison of the standard gamble, rating scale, AQLQ and SF-36 for measuring quality of life in asthma. Eur Respir J 18(1):38–44. https://doi.org/10.1183/09031936.01.00088301

CAS  Article  PubMed  Google Scholar 

Wang G, Wang F, Gibson PG et al (2017) Severe and uncontrolled asthma in China: a cross-sectional survey from the Australasian severe asthma network. J Thorac Dis 9(5):1333–1344. https://doi.org/10.21037/jtd.2017.04.74

Article  PubMed  PubMed Central  Google Scholar 

Zhou X, Ding FM, Lin JT et al (2009) Validity of asthma control test for asthma control assessment in Chinese primary care settings. Chest 135(4):904–910. https://doi.org/10.1378/chest.08-0967

Article  PubMed  Google Scholar 

Jia CE, Zhang HP, Lv Y et al (2013) The asthma control Test and asthma control questionnaire for assessing asthma control: systematic review and meta-analysis. J Allergy Clin Immunol 131(3):695–703. https://doi.org/10.1016/j.jaci.2012.08.023

Article  PubMed  Google Scholar 

Reddel HK, Taylor DR, Bateman ED et al (2009) An official american thoracic society/european respiratory society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 180(1):59–99. https://doi.org/10.1164/rccm.200801-060ST

Article  PubMed  Google Scholar 

Wang G, Baines KJ, Fu JJ et al (2016) Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma. Eur Respir J 47(4):1123–1133. https://doi.org/10.1183/13993003.01098-2015

CAS  Article  PubMed  Google Scholar 

Dunn WB, Broadhurst D, Begley P et al (2011) Procedures for large-scale metabolic profiling of serum and serum using gas chromatography and liquid chromatography coupled to mass spectrometry. Nat Protoc 6(7):1060–1083

CAS  Article  Google Scholar 

Wang J, Zhang T, Shen X et al (2016) Serum metabolomics for early diagnosis of esophageal squamous cell carcinoma by UHPLC-QTOF/MS. Metabolomics 12(7):116

Article  Google Scholar 

Dougherty RH, Fahy JV (2009) Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype. Clin Exp Allergy 39(2):193–202. https://doi.org/10.1111/j.1365-2222.2008.03157.x

CAS  Article  PubMed  PubMed Central  Google Scholar 

Park GM, Han HW, Kim JY et al (2016) Association of symptom control with changes in lung function, bronchial hyperresponsiveness, and exhaled nitric oxide after inhaled corticosteroid treatment in children with asthma. Allergol Int 65(4):439–443. https://doi.org/10.1016/j.alit.2016.03.011

CAS  Article  PubMed  Google Scholar 

Ammar M, Bahloul N, Amri O et al (2022) Oxidative stress in patients with asthma and its relation to uncontrolled asthma. J Clin Lab Anal 36(5):e24345. https://doi.org/10.1002/jcla.24345

CAS  Article  PubMed  PubMed Central  Google Scholar 

Zhang Y, Do DC, Hu X et al (2021) CaMKII oxidation regulates cockroach allergen-induced mitophagy in asthma. J Allergy Clin Immunol 147(4):1464-1477.e11. https://doi.org/10.1016/j.jaci.2020.08.033

CAS  Article  PubMed  Google Scholar 

Hinchy EC, Gruszczyk AV, Willows R et al (2018) Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly. J Biol Chem 293(44):17208–17217. https://doi.org/10.1074/jbc.RA118.002579

CAS  Article  PubMed  PubMed Central  Google Scholar 

Loo SL, Wark PAB (2016) Recent advances in understanding and managing asthma. F1000Res. https://doi.org/10.12688/f1000research.9236.1

Article  PubMed  PubMed Central  Google Scholar 

Ilmarinen P, Tuomisto LE, Niemelä O et al (2016) Comorbidities and elevated IL-6 associate with negative outcome in adult-onset asthma. Eur Respir J 48(4):1052–1062. https://doi.org/10.1183/13993003.02198-2015

CAS  Article  PubMed  Google Scholar 

Tanaka T, Narazaki M, Kishimoto T (2014) IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol 6(10):a016295. https://doi.org/10.1101/cshperspect.a016295

Article  PubMed  PubMed Central  Google Scholar 

Panther E, Dürk T, Ferrari D et al (2012) AMP affects intracellular Ca2+ signaling, migration, cytokine secretion and T cell priming capacity of dendritic cells. PLoS ONE 7(5):e37560. https://doi.org/10.1371/journal.pone.0037560

CAS  Article  PubMed  PubMed Central  Google Scholar 

Jakwerth CA, Ordovas-Montanes J, Blank S et al (2022) Role of respiratory epithelial cells in allergic diseases. Cells 11(9):1387

CAS  Article  Google Scholar 

Musiol S, Alessandrini F, Jakwerth CA et al (2022) TGF-β1 drives inflammatory Th cell but not Treg Cell compartment upon allergen exposure. Front Immunol. https://doi.org/10.3389/fimmu.2021.763243

Article  PubMed  PubMed Central  Google Scholar 

Weckmann M, Bahmer T, Sand JM et al (2021) COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy. Eur Respir J 58:200396. https://doi.org/10.1183/13993003.03969-2020

CAS  Article  Google Scholar 

Zissler UM, Jakwerth CA, Guerth F et al (2021) Allergen-specific immunotherapy induces the suppressive secretoglobin 1A1 in cells of the lower airways. Allergy 76(8):2461–2474. https://doi.org/10.1111/all.14756

CAS  Article  PubMed  Google Scholar 

Liu MC, Bleecker ER, Lichtenstein LM et al (1990) Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. Am Rev Respir Dis 142(1):126–132. https://doi.org/10.1164/ajrccm/142.1.126

CAS  Article  PubMed  Google Scholar 

Esther CR Jr, Boysen G et al (2009) Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 296(6):L987–L993. https://doi.org/10.1152/ajplung.90512.2008

CAS  Article  PubMed  PubMed Central  Google Scholar 

Yamauchi K, Ogasawara M (2019) The Role of histamine in the pathophysiology of asthma and the clinical efficacy of antihistamines in asthma therapy. Int J Mol Sci. https://doi.org/10.3390/ijms20071733

Article  PubMed  PubMed Central  Google Scholar 

Koarai A, Ichinose M, Ishigaki-Suzuki S et al (2003) Disruption of L-histidine decarboxylase reduces airway eosinophilia but not hyperresponsiveness. Am J Respir Crit Care Med 167(5):758–763. https://doi.org/10.1164/rccm.200206-619OC

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