Masoli M, Fabian D, Holt S et al (2004) The global burden of asthma: executive summary of the GINA dissemination committee report. Allergy 59(5):469–478. https://doi.org/10.1111/j.1398-9995.2004.00526.x
Stern J, Pier J, Litonjua AA (2020) Asthma epidemiology and risk factors. Semin Immunopathol 42(1):5–15. https://doi.org/10.1007/s00281-020-00785-1
Global Initiative for Asthma (2020) Global Strategy for Asthma Management and Prevention www.ginasthma.org
Hallstrand TS, Leuppi JD, Joos G et al (2018) ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing. Eur Respir J 52(5):1801033. https://doi.org/10.1183/13993003.01033-2018
CAS Article PubMed Google Scholar
Kistemaker LE, Gosens R (2015) Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling. Trends Pharmacol Sci 36(3):164–171. https://doi.org/10.1016/j.tips.2014.11.005
CAS Article PubMed Google Scholar
Gori S, Vermeulen M, Remes-Lenicov F et al (2017) Acetylcholine polarizes dendritic cells toward a Th2-promoting profile. Allergy 72(2):221–231. https://doi.org/10.1111/all.12926
CAS Article PubMed Google Scholar
Dunford PJ, Holgate ST (2010) The role of histamine in asthma. Adv Exp Med Biol 709:53–66. https://doi.org/10.1007/978-1-4419-8056-4_6
CAS Article PubMed Google Scholar
van den Berge M, Polosa R, Kerstjens HA et al (2004) The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol 114(4):737–746. https://doi.org/10.1016/j.jaci.2004.05.071
CAS Article PubMed Google Scholar
Taylor DA, Jensen MW, Kanabar V et al (1999) A dose-dependent effect of the novel inhaled corticosteroid ciclesonide on airway responsiveness to adenosine-5′-monophosphate in asthmatic patients. Am J Respir Crit Care Med 160(1):237–243. https://doi.org/10.1164/ajrccm.160.1.9809046
CAS Article PubMed Google Scholar
Cockcroft DW (2010) Direct challenge tests: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 138(2 Suppl):18s–24s. https://doi.org/10.1378/chest.10-0088
CAS Article PubMed Google Scholar
Tsurikisawa N, Oshikata C, Tsuburai T et al (2010) Bronchial reactivity to histamine is correlated with airway remodeling in adults with moderate to severe asthma. J Asthma 47(8):841–848. https://doi.org/10.3109/02770903.2010.504876
CAS Article PubMed Google Scholar
Kim CK, Hagan JB (2004) Sputum tests in the diagnosis and monitoring of asthma. Ann Allergy Asthma Immunol 93(2):112–122. https://doi.org/10.1016/s1081-1206(10)61462-7
Nathan RA, Sorkness CA, Kosinski M et al (2004) Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 113(1):59–65. https://doi.org/10.1016/j.jaci.2003.09.008
Juniper EF, Norman GR, Cox FM et al (2001) Comparison of the standard gamble, rating scale, AQLQ and SF-36 for measuring quality of life in asthma. Eur Respir J 18(1):38–44. https://doi.org/10.1183/09031936.01.00088301
CAS Article PubMed Google Scholar
Wang G, Wang F, Gibson PG et al (2017) Severe and uncontrolled asthma in China: a cross-sectional survey from the Australasian severe asthma network. J Thorac Dis 9(5):1333–1344. https://doi.org/10.21037/jtd.2017.04.74
Article PubMed PubMed Central Google Scholar
Zhou X, Ding FM, Lin JT et al (2009) Validity of asthma control test for asthma control assessment in Chinese primary care settings. Chest 135(4):904–910. https://doi.org/10.1378/chest.08-0967
Jia CE, Zhang HP, Lv Y et al (2013) The asthma control Test and asthma control questionnaire for assessing asthma control: systematic review and meta-analysis. J Allergy Clin Immunol 131(3):695–703. https://doi.org/10.1016/j.jaci.2012.08.023
Reddel HK, Taylor DR, Bateman ED et al (2009) An official american thoracic society/european respiratory society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 180(1):59–99. https://doi.org/10.1164/rccm.200801-060ST
Wang G, Baines KJ, Fu JJ et al (2016) Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma. Eur Respir J 47(4):1123–1133. https://doi.org/10.1183/13993003.01098-2015
CAS Article PubMed Google Scholar
Dunn WB, Broadhurst D, Begley P et al (2011) Procedures for large-scale metabolic profiling of serum and serum using gas chromatography and liquid chromatography coupled to mass spectrometry. Nat Protoc 6(7):1060–1083
Wang J, Zhang T, Shen X et al (2016) Serum metabolomics for early diagnosis of esophageal squamous cell carcinoma by UHPLC-QTOF/MS. Metabolomics 12(7):116
Dougherty RH, Fahy JV (2009) Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype. Clin Exp Allergy 39(2):193–202. https://doi.org/10.1111/j.1365-2222.2008.03157.x
CAS Article PubMed PubMed Central Google Scholar
Park GM, Han HW, Kim JY et al (2016) Association of symptom control with changes in lung function, bronchial hyperresponsiveness, and exhaled nitric oxide after inhaled corticosteroid treatment in children with asthma. Allergol Int 65(4):439–443. https://doi.org/10.1016/j.alit.2016.03.011
CAS Article PubMed Google Scholar
Ammar M, Bahloul N, Amri O et al (2022) Oxidative stress in patients with asthma and its relation to uncontrolled asthma. J Clin Lab Anal 36(5):e24345. https://doi.org/10.1002/jcla.24345
CAS Article PubMed PubMed Central Google Scholar
Zhang Y, Do DC, Hu X et al (2021) CaMKII oxidation regulates cockroach allergen-induced mitophagy in asthma. J Allergy Clin Immunol 147(4):1464-1477.e11. https://doi.org/10.1016/j.jaci.2020.08.033
CAS Article PubMed Google Scholar
Hinchy EC, Gruszczyk AV, Willows R et al (2018) Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly. J Biol Chem 293(44):17208–17217. https://doi.org/10.1074/jbc.RA118.002579
CAS Article PubMed PubMed Central Google Scholar
Loo SL, Wark PAB (2016) Recent advances in understanding and managing asthma. F1000Res. https://doi.org/10.12688/f1000research.9236.1
Article PubMed PubMed Central Google Scholar
Ilmarinen P, Tuomisto LE, Niemelä O et al (2016) Comorbidities and elevated IL-6 associate with negative outcome in adult-onset asthma. Eur Respir J 48(4):1052–1062. https://doi.org/10.1183/13993003.02198-2015
CAS Article PubMed Google Scholar
Tanaka T, Narazaki M, Kishimoto T (2014) IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol 6(10):a016295. https://doi.org/10.1101/cshperspect.a016295
Article PubMed PubMed Central Google Scholar
Panther E, Dürk T, Ferrari D et al (2012) AMP affects intracellular Ca2+ signaling, migration, cytokine secretion and T cell priming capacity of dendritic cells. PLoS ONE 7(5):e37560. https://doi.org/10.1371/journal.pone.0037560
CAS Article PubMed PubMed Central Google Scholar
Jakwerth CA, Ordovas-Montanes J, Blank S et al (2022) Role of respiratory epithelial cells in allergic diseases. Cells 11(9):1387
Musiol S, Alessandrini F, Jakwerth CA et al (2022) TGF-β1 drives inflammatory Th cell but not Treg Cell compartment upon allergen exposure. Front Immunol. https://doi.org/10.3389/fimmu.2021.763243
Article PubMed PubMed Central Google Scholar
Weckmann M, Bahmer T, Sand JM et al (2021) COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy. Eur Respir J 58:200396. https://doi.org/10.1183/13993003.03969-2020
Zissler UM, Jakwerth CA, Guerth F et al (2021) Allergen-specific immunotherapy induces the suppressive secretoglobin 1A1 in cells of the lower airways. Allergy 76(8):2461–2474. https://doi.org/10.1111/all.14756
CAS Article PubMed Google Scholar
Liu MC, Bleecker ER, Lichtenstein LM et al (1990) Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. Am Rev Respir Dis 142(1):126–132. https://doi.org/10.1164/ajrccm/142.1.126
CAS Article PubMed Google Scholar
Esther CR Jr, Boysen G et al (2009) Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 296(6):L987–L993. https://doi.org/10.1152/ajplung.90512.2008
CAS Article PubMed PubMed Central Google Scholar
Yamauchi K, Ogasawara M (2019) The Role of histamine in the pathophysiology of asthma and the clinical efficacy of antihistamines in asthma therapy. Int J Mol Sci. https://doi.org/10.3390/ijms20071733
Article PubMed PubMed Central Google Scholar
Koarai A, Ichinose M, Ishigaki-Suzuki S et al (2003) Disruption of L-histidine decarboxylase reduces airway eosinophilia but not hyperresponsiveness. Am J Respir Crit Care Med 167(5):758–763. https://doi.org/10.1164/rccm.200206-619OC
留言 (0)