Background: GBA1 variants are among the most common genetic risk factors for Parkinson Disease (PD). GBA1 variants can be classified into three categories based on their role in Gaucher Disease (GD) or PD: severe, mild, and risk variant (for PD). Objectives: This paper aims to generate and share a comprehensive database for GBA1 variants reported in PD to support future research and clinical trials. Methods: We performed a literature search for all GBA1 variants that have been reported in PD. The data has been standardized and complimented with variant classification, Odds Ratio (OR) if available and other data. Results: We found 371 GBA1 variants reported in PD: 22 mild, 84 severe, 3 risk variants, and 262 of unknown status. We created a browser, containing up-to-date information on these variants (https://pdgenetics.shinyapps.io/GBA1Browser/). Conclusions: The classification and browser presented in this work should inform and support basic, translational, and clinical research on GBA1-PD.

The authors have declared no competing interest.

This work has been supported by grants from the Michael J. Fox Foundation and the Canadian Consortium on Neurodegeneration in Aging (CCNA). This work was supported in part by the Intramural Research Programs of the National Institute on Aging (NIA).

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.

Yes