Anticancer and chemosensitization effects of cannabidiol in 2D and 3D cultures of TNBC: involvement of GADD45α, integrin-α5, -β5, -β1, and autophagy

Torre LA, Siegel RL, Ward EM, Jemal A. Global cancer incidence and mortality rates and trends—an update. Cancer Epidemiol Prev Biomark. 2016;25:16–27.

Article  Google Scholar 

Pérez-García J, Soberino J, Racca F, Gion M, Stradella A, Cortés J. Atezolizumab in the treatment of metastatic triple-negative breast cancer. Expert Opin Biol Ther. 2020;20:981–9.

PubMed  Article  Google Scholar 

Broglio KR, Quintana M, Foster M, Olinger M, McGlothlin A, Berry SM, et al. Association of pathologic complete response to neoadjuvant therapy in HER2-positive breast cancer with long-term outcomes: a meta-analysis. JAMA Oncol. 2016;2:751–60.

PubMed  Article  Google Scholar 

Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, et al. Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008;14:8010–8.

CAS  PubMed  Article  Google Scholar 

LeClair JN, Chamberlin KW, Clement J, Holle LM. Documentation of medical marijuana use in cancer patients. J Oncol Pharm Pract. 2020;26:1117–27.

PubMed  Article  Google Scholar 

Williamson EM, Evans FJ. Cannabinoids in clinical practice. Drugs. 2000;60:1303–14.

CAS  PubMed  Article  Google Scholar 

Atakan Z. Cannabis, a complex plant: different compounds and different effects on individuals. Ther Adv Psychopharmacol. 2012;2:241–54.

CAS  PubMed  PubMed Central  Article  Google Scholar 

McAllister SD, Murase R, Christian RT, Lau D, Zielinski AJ, Allison J, et al. Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat. 2011;129:37–47.

CAS  PubMed  Article  Google Scholar 

Alexander A, Smith PF, Rosengren RJ. Cannabinoids in the treatment of cancer. Cancer Lett. 2009;285:6–12.

CAS  PubMed  Article  Google Scholar 

Kovalchuk O, Kovalchuk I. Cannabinoids as anticancer therapeutic agents. Cell Cycle. 2020;19:961–89.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ghanem A, Emara HA, Muawia S, Abd El Maksoud AI, Al-Karmalawy AA, Elshal MF. Tanshinone IIA synergistically enhances the antitumor activity of doxorubicin by interfering with the PI3K/AKT/mTOR pathway and inhibition of topoisomerase II: in vitro and molecular docking studies. New J Chem. 2020; 44: 17374–17381.

Chen C, Lu L, Yan S, Yi H, Yao H, Wu D, et al. Autophagy and doxorubicin resistance in cancer. Anticancer Drugs. 2018;29:1–9.

PubMed  Article  Google Scholar 

Patel N, Kommineni N, Surapaneni SK, Kalvala A, Yaun X, Gebeyehu A et al. Cannabidiol loaded extracellular vesicles sensitize triple-negative breast cancer to doxorubicin in both in-vitro and in vivo models. Int J Pharm. 2021; 607: 120943.

Pan YZ, Wang X, Bai H, Wang CB, Zhang Q, Xi R. Autophagy in drug resistance of the multiple myeloma cell line RPMI8226 to doxorubicin. Genet Mol Res. 2015;14:5621–9.

CAS  PubMed  Article  Google Scholar 

de Oliveira Júnior RG, Adrielly AFC, da Silva Almeida JRG, Grougnet R, Thiery V, Picot L. Sensitization of tumor cells to chemotherapy by natural products: a systematic review of preclinical data and molecular mechanisms. Fitoterapia. 2018;129:383–400.

PubMed  Article  Google Scholar 

Doddapaneni R, Patel K, Chowdhury N, Singh M. Reversal of drug-resistance by noscapine chemo-sensitization in docetaxel resistant triple negative breast cancer. Sci Rep. 2017;7:1–11.

CAS  Article  Google Scholar 

Scott KA, Dalgleish AG, Liu WM. The combination of cannabidiol and Δ9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model. Mol Cancer Ther. 2014;13:2955–67.

CAS  PubMed  Article  Google Scholar 

Nabissi M, Morelli MB, Santoni M, Santoni G. Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Carcinogenesis. 2013;34:48–57.

CAS  PubMed  Article  Google Scholar 

Fraguas-Sánchez A, Fernández-Carballido A, Simancas-Herbada R, Martin-Sabroso C, Torres-Suárez A. CBD loaded microparticles as a potential formulation to improve paclitaxel and doxorubicin-based chemotherapy in breast cancer. Int J Pharm. 2020; 574: 118916.

Surapaneni SK, Bhat ZR, Tikoo K. MicroRNA-941 regulates the proliferation of breast cancer cells by altering histone H3 Ser 10 phosphorylation. Sci Rep. 2020;10:17954.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 2006;58:621–81.

CAS  PubMed  Article  Google Scholar 

Zhang N, Fu JN, Chou TC. Synergistic combination of microtubule targeting anticancer fludelone with cytoprotective panaxytriol derived from panax ginseng against MX-1 cells in vitro: experimental design and data analysis using the combination index method. Am J Cancer Res. 2016;6:97–104.

CAS  PubMed  Google Scholar 

Arthur P, Patel N, Surapaneni SK, Mondal A, Gebeyehu A, Bagde A et al. Targeting lung cancer stem cells using combination of Tel and Docetaxel liposomes in 3D cultures and tumor xenografts. Toxicol Appl Pharmacol. 2020; 401: 115112.

Surapaneni SK, Bashir S, Tikoo K. Gold nanoparticles-induced cytotoxicity in triple negative breast cancer involves different epigenetic alterations depending upon the surface charge. Sci Rep. 2018;8:12295.

PubMed  PubMed Central  Article  Google Scholar 

Patel AR, Chougule MB, Patlolla R, Wang G, Singh M. Efficacy of aerosolized celecoxib encapsulated nanostructured lipid carrier in non-small cell lung cancer in combination with docetaxel. Pharm Res. 2013;30:1435–46.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Cui J, Zhao H, Wang C, Sun JJ, Lu K, Ma D. Dexmedetomidine attenuates oxidative stress induced lung alveolar epithelial cell apoptosis in vitro. Oxid Med Cell Longev. 2015; 2015: 358396.

Kalvala AK, Yerra VG, Sherkhane B, Gundu C, Arruri V, Kumar R, et al. Chronic hyperglycemia impairs mitochondrial unfolded protein response and precipitates proteotoxicity in experimental diabetic neuropathy: focus on LonP1 mediated mitochondrial regulation. Pharmacol Rep. 2020;72:1627–44.

CAS  PubMed  Article  Google Scholar 

Thummuri D, Kumar S, Surapaneni SK, Tikoo K. Epigenetic regulation of protein tyrosine phosphatase PTPN12 in triple-negative breast cancer. Life Sci. 2015;130:73–80.

CAS  PubMed  Article  Google Scholar 

Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG. Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol. 2010;160:1577–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, et al. A living biobank of breast cancer organoids captures disease heterogeneity. Cell. 2018;172:373-386.e310.

CAS  PubMed  Article  Google Scholar 

Nkosi D, Sun L, Duke LC, Meckes DG, Jr. Epstein-Barr virus LMP1 manipulates the content and functions of extracellular vesicles to enhance metastatic potential of recipient cells. PLoS Pathog. 2020; 16: e1009023.

Zhou G, Soufan O, Ewald J, Hancock REW, Basu N, Xia J. NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis. Nucleic Acids Res. 2019; 47: W234-w241.

McDermaid A, Monier B, Zhao J, Liu B, Ma Q. Interpretation of differential gene expression results of RNA-seq data: review and integration. Brief Bioinform. 2019;20:2044–54.

PubMed  Article  Google Scholar 

Hedrick E, Lee S-O, Doddapaneni R, Singh M, Safe S. NR4A1 antagonists inhibit β1-integrin-dependent breast cancer cell migration. Mol Cell Biol. 2016;36:1383–94.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Liu XF, Yang WT, Xu R, Liu JT, Zheng PS. Cervical cancer cells with positive Sox2 expression exhibit the properties of cancer stem cells. PLoS One. 2014; 9: e87092.

Liu X, Sun Y, Guo J, Ma H, Li J, Dong B, et al. Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int J Cancer. 2006;118:1922–9.

CAS  PubMed  Article  Google Scholar 

Kalvala AK, Yerra VG, Kumar A. LONP1 induction by SRT1720 attenuates mitochondrial dysfunction against high glucose induced neurotoxicity in PC12 cells. Toxicol In Vitro. 2020; 62: 104695.

McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez PY. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Mol Cancer Ther. 2007;6:2921–7.

CAS  PubMed  Article  Google Scholar 

Bissell MJ. Architecture is the message: the role of extracellular matrix and 3-D structure in tissue-specific gene expression and breast cancer. The Pezcoller Foundation journal: news from the Pezcoller Foundation world. 2007;16:2.

Google Scholar 

Lv D, Hu Z, Lu L, Lu H, Xu X. Three-dimensional cell culture: a powerful tool in tumor research and drug discovery. Oncol Lett. 2017;14:6999–7010.

PubMed  PubMed Central  Google Scholar 

Edmondson R, Broglie JJ, Adcock AF, Yang L. Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors. Assay Drug Dev Technol. 2014;12:207–18.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Theodoraki MA, Rezende CO Jr, Chantarasriwong O, Corben AD, Theodorakis EA, Alpaugh ML. Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening. Oncotarget. 2015;6:21255–67.

PubMed  PubMed Central  Article  Google Scholar 

Michor F, Weaver VM. Understanding tissue context influences on intratumour heterogeneity. Nat Cell Biol. 2014;16:301–2.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sachs N, Clevers H. Organoid cultures for the analysis of cancer phenotypes. Curr Opin Genet Dev. 2014;24:68–73.

CAS  PubMed  Article  Google Scholar 

Godugu C, Patel AR, Desai U, Andey T, Sams A, Singh M. AlgiMatrix™ based 3D cell culture system as an in-vitro tumor model for anticancer studies. PLoS One. 2013; 8: e53708.

Baek N, Seo OW, Kim M, Hulme J, An SSA. Monitoring the effects of doxorubicin on 3D-spheroid tumor cells in real-time. Onco Targets Ther. 2016;9:7207.

CAS  PubMed  PubMed Central  Article  Google Scholar 

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