Evidence for Anti-inflammatory Effects of Adalimumab in Treatment of Patients With Major Depressive Disorder: A Pilot, Randomized, Controlled Trial

∗Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences

†Faculty of Medicine, Shahid Beheshti University of Medical Sciences

‡Mental Health Research Center, Psychological Health Research Institute, Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Address correspondence and reprint requests to Shahin Akhondzadeh, PhD, Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, S Kargar St, Tehran, Iran 13337; E-mail: [email protected]

The first 3 authors contributed equally in to this study.

Conflicts of Interest and Source of Funding: The authors have no conflict of interest to disclose. This study was supported by a grant from Tehran University of Medical Sciences to S.A. (grant number 41910). The funding organization had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the article and the decision to submit the article for publication.

Authors Contributions: F.A., S.B., K.M., M.K., A.E., F.-S.S., and S.V. participated in data acquisition analysis and preparation of the first draft of manuscript. S.A., M.S., and B.S. designed the manuscript, provided the outlines for presentation of the study, supervised the study process, and edited the final manuscript. All authors have reviewed the process of data analysis, commented on previous versions of the manuscript, and approved the final article.

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