Synapsin autoantibodies during pregnancy are associated with fetal abnormalities

Abstract

Anti-neuronal autoantibodies can be transplacentally transferred during pregnancy and may cause detrimental effects on fetal development. It is unclear whether autoantibodies against synapsin-I, one of the most abundant synaptic proteins, are associated with developmental abnormalities in humans. We prospectively recruited a cohort of 263 pregnant women and detected serum synapsin-I IgG autoantibodies in 13.3%. Seropositivity was strongly associated with abnormalities of fetal development including intrauterine growth retardation. This finding indicates that these autoantibodies may be clinically useful developmental biomarkers and/or even directly participate in the disease process, thus being amenable to antibody-targeting interventional strategies in the future.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

This work was supported by grants from the German Research Foundation (DFG) (grants FOR3004, PR1274/4-1, PR1274/5-1, PR1274/9-1), by the Helmholtz Association (HIL-A03), and by the German Federal Ministry of Education and Research (Connect-Generate 01GM1908D) to H.P. The study was supported by the Einstein Stiftung Fellowship through the Guenter Endres Fond and the Sonnenfeld-Stiftung (A.M.K.). DM is supported by the start-up funds from DZNE and the German Research Foundation (SFB MI 2104 and 1286/B10).

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I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

Ethics Committee of the Charite Universitaetsmedizin Berlin gave ethical approval for this work (#EA2/220/20).

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Data Availability

All data produced in the present study are available upon reasonable request to the authors

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