Constantinescu DS, Campbell MP, Moatshe G, Vap AR. Effects of perioperative nonsteroidal anti-inflammatory drug administration on soft tissue healing: a systematic review of clinical outcomes after sports medicine orthopaedic surgery procedures. Orthop J Sports Med. 2019;7(4):2325967119838873.
PubMed PubMed Central Article Google Scholar
Zhang JM, An J. Cytokines, inflammation, and pain. Int Anesthesiol Clin. 2007;45(2):27–37.
CAS PubMed PubMed Central Article Google Scholar
Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell. 2010;140(6):771–6.
CAS PubMed Article Google Scholar
Kunnumakkara AB, Sailo BL, Banik K, Harsha C, Prasad S, Gupta SC, et al. Chronic diseases, inflammation, and spices: how are they linked? J Transl Med. 2018;16(1):14.
CAS PubMed PubMed Central Article Google Scholar
Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017;9(6):7204–18.
PubMed PubMed Central Article Google Scholar
Aggarwal BB, Van Kuiken ME, Iyer LH, Harikumar KB, Sung B. Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis. Exp Biol Med (Maywood). 2009;234(8):825–49.
Moore N. Diclofenac potassium 12.5 mg tablets for mild to moderate pain and fever: a review of its pharmacology, clinical efficacy and safety. Clin Drug Investig. 2007;27(3):163–95.
CAS PubMed Article Google Scholar
Moore N, Charlesworth A, Van Ganse E, LeParc JM, Jones JK, Wall R, et al. Risk factors for adverse events in analgesic drug users: results from the PAIN study. Pharmacoepidemiol Drug Saf. 2003;12(7):601–10.
CAS PubMed Article Google Scholar
Moore N, Vanganse E, Leparc J, Wall R, Schneid H, Farhan M, et al. A large-scale, randomised clinical trial comparing the tolerability of aspirin, ibuprofen and paracetamol for short-term analgesia. Clin Drug Invest. 1999;18:89–98.
Ong CK, Lirk P, Tan CH, Seymour RA. An evidence-based update on nonsteroidal anti-inflammatory drugs. Clin Med Res. 2007;5(1):19–34.
CAS PubMed PubMed Central Article Google Scholar
Perry TA, Wang X, Nevitt M, Abdelshaheed C, Arden N, Hunter DJ. Association between current medication use and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative. Rheumatology (Oxford). 2021;60(10):4624–32.
CAS PubMed Central Article Google Scholar
Micallef J, Soeiro T, Jonville-Béra AP. Non-steroidal anti-inflammatory drugs, pharmacology, and COVID-19 infection. Therapie. 2020;75(4):355–62.
PubMed PubMed Central Article Google Scholar
Ueberall MA, Mueller-Schwefe GH, Wigand R, Essner U. Efficacy, tolerability, and safety of an oral enzyme combination vs. diclofenac in osteoarthritis of the knee: results of an individual patient-level pooled reanalysis of data from six randomized controlled trials. J Pain Res. 2016;9:941–61.
CAS PubMed PubMed Central Article Google Scholar
Leipner J, Saller R. Systemic enzyme therapy in oncology: effect and mode of action. Drugs. 2000;59(4):769–80.
CAS PubMed Article Google Scholar
Lauer D, Müller R, Cott C, Otto A, Naumann M, Birkenmeier G. Modulation of growth factor binding properties of a2-macroglobulin by enzyme therapy. Cancer Chemother Pharmacol. 2001;47(1):S4–9.
CAS PubMed Article Google Scholar
Kameníček V, Holán P, Franĕk P. Systemic enzyme therapy in the treatment and prevention of post-traumatic and postoperative swelling. Acta Chir Orthop Traumatol Cech. 2001;68(1):45–9.
Beard J. The enzyme treatment of cancer and its scientific basis. London: Chatto & Windus; 1911.
Beuth J. Proteolytic enzyme therapy in evidence-based complementary oncology: fact or fiction? Integr Cancer Ther. 2008;7(4):311–6.
CAS PubMed Article Google Scholar
Marzin T, Lorkowski G, Reule C, Rau S, Pabst E, Vester JC, et al. Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial. BMJ Open Sport Exerc Med. 2016;2(1): e000191.
Paradis M-E, Couture P, Gigleux I, Marin J, Vohl M-C, Lamarche B. Impact of systemic enzyme supplementation on low-grade inflammation in humans. PharmaNutrition. 2015;3(3):83–8.
Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012;64(6):1697–707.
PubMed PubMed Central Article Google Scholar
Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2020;72(2):149–62.
Litwic A, Edwards MH, Dennison EM, Cooper C. Epidemiology and burden of osteoarthritis. Br Med Bull. 2013;105:185–99.
Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986;29(8):1039–49.
CAS PubMed Article Google Scholar
Palazzo C, Nguyen C, Lefevre-Colau MM, Rannou F, Poiraudeau S. Risk factors and burden of osteoarthritis. Ann Phys Rehabil Med. 2016;59(3):134–8.
United Nations - Department of Economic Social Affairs - Population Division. World population ageing 2019: Highlights. 2019 [Available from: https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Highlights.pdf.
Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarth Study. Arthritis Rheum. 1987;30(8):914–8.
CAS PubMed Article Google Scholar
Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2163–96.
PubMed PubMed Central Article Google Scholar
Scarpellini E, Tack J. Obesity and metabolic syndrome: an inflammatory condition. Dig Dis. 2012;30(2):148–53.
CAS PubMed Article Google Scholar
Marques-Rocha JL, Samblas M, Milagro FI, Bressan J, Martinez JA, Marti A. Noncoding RNAs, cytokines, and inflammation-related diseases. FASEB J. 2015;29(9):3595–611.
CAS PubMed Article Google Scholar
Duclos M. Osteoarthritis, obesity and type 2 diabetes: The weight of waist circumference. Ann Phys Rehabil Med. 2016;59(3):157–60.
Frasca D, Blomberg BB, Paganelli R. Aging, obesity, and inflammatory age-related diseases. Front Immunol. 2017;8:1745.
PubMed PubMed Central Article Google Scholar
Rezus E, Cardoneanu A, Burlui A, Luca A, Codreanu C, Tamba BI, et al. The link between inflammaging and degenerative joint diseases. Int J Mol Sci. 2019;20(3):614.
CAS PubMed Central Article Google Scholar
Loeser RF, Collins JA, Diekman BO. Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12(7):412–20.
CAS PubMed PubMed Central Article Google Scholar
Lewis-McDougall FC, Ruchaya PJ, Domenjo-Vila E, Shin Teoh T, Prata L, Cottle BJ, et al. Aged-senescent cells contribute to impaired heart regeneration. Aging Cell. 2019;18(3): e12931.
PubMed PubMed Central Article Google Scholar
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, et al. Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMedicine. 2019;47:446–56.
PubMed PubMed Central Article Google Scholar
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, et al. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018;24(8):1246–56.
CAS PubMed PubMed Central Article Google Scholar
Bruyere O, Honvo G, Veronese N, Arden NK, Branco J, Curtis EM, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019;49(3):337–50.
Briani RV, Ferreira AS, Pazzinatto MF, Pappas E, De Oliveira Silva D, Azevedo FM. What interventions can improve quality of life or psychosocial factors of individuals with knee osteoarthritis? A systematic review with meta-analysis of primary outcomes from randomised controlled trials. Br J Sports Med. 2018;52(16):1031–8.
Katz JN, Arant KR, Loeser RF.
留言 (0)