Chen, D. Osteoarthritis: a complicated joint disease requiring extensive studies with multiple approaches. J. Orthop. Translat. 32, 130 (2022).
PubMed PubMed Central Article Google Scholar
Chen, D. et al. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res. 5, 16044 (2017).
CAS PubMed PubMed Central Article Google Scholar
Li, Y., Xie, W., Xiao, W. & Dou, D. Progress in osteoarthritis research by the National Natural Science Foundation of China. Bone Res. 10, 41 (2022).
CAS PubMed PubMed Central Article Google Scholar
Sun, A. R. et al. Cartilage tissue engineering for obesity-induced osteoarthritis: physiology, challenges, and future prospects. J. Orthop. Translat. 26, 3–15 (2021).
Wu, X. H., Lai, Y. M., Cao, H. L. & Xiao, G. Z. Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis. J. Bone Min. Res. 37, 45–46 (2022).
Wen, C. & Xiao, G. Advances in osteoarthritis research in 2021 and beyond. J. Orthop. Translat. 32, A1–A2 (2022).
PubMed PubMed Central Article Google Scholar
GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392, 1789–1858 (2018).
Li, J., Wang, Y., Chen, D. & Liu-Bryan, R. Oral administration of berberine limits post-traumatic osteoarthritis development and associated pain via AMP-activated protein kinase (AMPK) in mice. Osteoarthr. Cartil. 30, 160–171 (2022).
Li, J. et al. Metformin limits osteoarthritis development and progression through activation of AMPK signalling. Ann. Rheum. Dis. 79, 635–645 (2020).
CAS PubMed Article Google Scholar
Lu, K. et al. Molecular signaling in temporomandibular joint osteoarthritis. J. Orthop. Translat. 32, 21–27 (2022).
Katz, J. N., Arant, K. R. & Loeser, R. F. Diagnosis and treatment of hip and knee osteoarthritis: a review. JAMA 325, 568–578 (2021).
CAS PubMed PubMed Central Article Google Scholar
Ni, R., Guo, X. E., Yan, C. & Wen, C. Hemodynamic stress shapes subchondral bone in osteoarthritis: An emerging hypothesis. J. Orthop. Translat. 32, 85–90 (2022).
McHugh, J. Osteoarthritis risk factors differ between sexes. Nat. Rev. Rheumatol. 17, 312 (2021).
PubMed PubMed Central Google Scholar
Huang, W., Ong, T. Y., Fu, S. C. & Yung, S. H. Prevalence of patellofemoral joint osteoarthritis after anterior cruciate ligament injury and associated risk factors: a systematic review. J. Orthop. Translat. 22, 14–25 (2020).
Fang, L. et al. Defining disease progression in Chinese mainland people: association between bone mineral density and knee osteoarthritis. J. Orthop. Translat. 26, 39–44 (2021).
Hunter, D. J. & Bierma-Zeinstra, S. Osteoarthritis. Lancet 393, 1745–1759 (2019).
CAS PubMed Article Google Scholar
Chen, L. et al. Pathogenesis and clinical management of obesity-related knee osteoarthritis: Impact of mechanical loading. J. Orthop. Translat. 24, 66–75 (2020).
PubMed PubMed Central Article Google Scholar
Meurot, C. et al. Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: a new opportunity? J. Orthop. Translat. 32, 121–129 (2022).
CAS PubMed PubMed Central Article Google Scholar
Chen, D., Kim, D. J., Shen, J., Zou, Z. & O’Keefe, R. J. Runx2 plays a central role in Osteoarthritis development. J. Orthop. Translat. 23, 132–139 (2020).
Yu, H., Huang, T., Lu, W. W., Tong, L. & Chen, D. Osteoarthritis Pain. Int. J. Mol. Sci. 23, 4642 (2022).
Li, J., Ma, K., Yi, D., Oh, C. D. & Chen, D. Nociceptive behavioural assessments in mouse models of temporomandibular joint disorders. Int. J. Oral Sci. 12, 26 (2020).
CAS PubMed PubMed Central Article Google Scholar
Zhou, F. et al. Associations of osteoclastogenesis and nerve growth in subchondral bone marrow lesions with clinical symptoms in knee osteoarthritis. J. Orthop. Translat. 32, 69–76 (2022).
Yang, J. et al. Targeting cell death: pyroptosis, ferroptosis, apoptosis and necroptosis in osteoarthritis. Front. Cell Dev. Biol. 9, 789948 (2021).
Cao, M., Ong, M. T. Y., Yung, P. S. H., Tuan, R. S. & Jiang, Y. Role of synovial lymphatic function in osteoarthritis. Osteoarthr. Cartil. (2022).
Wang, W. et al. Attenuated joint tissue damage associated with improved synovial lymphatic function following treatment with bortezomib in a mouse model of experimental posttraumatic osteoarthritis. Arthritis Rheumatol. 71, 244–257 (2019).
CAS PubMed PubMed Central Article Google Scholar
Yu, H. et al. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling. J. Ethnopharmacol. 266, 113447 (2021).
CAS PubMed Article Google Scholar
Simon, T. C. & Jeffries, M. A. The epigenomic landscape in osteoarthritis. Curr. Rheumatol. Rep. 19, 30 (2017).
PubMed PubMed Central Article CAS Google Scholar
Zhang, M. & Wang, J. Epigenetics and osteoarthritis. Genes Dis. 2, 69–75 (2015).
PubMed PubMed Central Article Google Scholar
Roach, H. I. & Aigner, T. DNA methylation in osteoarthritic chondrocytes: a new molecular target. Osteoarthr. Cartil. 15, 128–137 (2007).
Miranda-Duarte, A. DNA methylation in osteoarthritis: current status and therapeutic implications. Open Rheumatol. J. 12, 37–49 (2018).
CAS PubMed PubMed Central Article Google Scholar
Morris, M. J. & Monteggia, L. M. Role of DNA methylation and the DNA methyltransferases in learning and memory. Dialogues Clin. Neurosci. 16, 359–371 (2014).
PubMed PubMed Central Article Google Scholar
Li, E., Bestor, T. H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915–926 (1992).
CAS PubMed Article Google Scholar
Okano, M., Bell, D. W., Haber, D. A. & Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247–257 (1999).
CAS PubMed Article Google Scholar
Jeffries, M. A. et al. Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage. Arthritis Rheumatol. 66, 2804–2815 (2014).
CAS PubMed Article Google Scholar
Raman, S., FitzGerald, U. & Murphy, J. M. Interplay of inflammatory mediators with epigenetics and cartilage modifications in osteoarthritis. Front. Bioeng. Biotechnol. 6, 22 (2018).
PubMed PubMed Central Article Google Scholar
Chen, D., Shen, J. & Hui, T. Epigenetic and microRNA regulation during osteoarthritis development. F1000Res. 4, F1000 Faculty Rev−1092 (2015).
Cheung, K. S., Hashimoto, K., Yamada, N. & Roach, H. I. Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation. Rheumatol. Int. 29, 525–534 (2009).
CAS PubMed Article Google Scholar
Hashimoto, K., Oreffo, R. O., Gibson, M. B., Goldring, M. B. & Roach, H. I. DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes. Arthritis Rheumatol. 60, 3303–3313 (2009).
Roach, H. I. et al. Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheumtol. 52, 3110–3124 (2005).
Shen, J., Abu-Amer, Y., O’Keefe, R. J. & McAlinden, A. Inflammation and epigenetic regulation in osteoarthritis. Connect. Tissue Res. 58, 49–63 (2017).
CAS PubMed Article Google Scholar
Zimmermann, P. et al. Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter. Arthritis Rheumatol. 58, 2743–2753 (2008).
Tan, L. & Shi, Y. G. Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development 139, 1895–1902 (2012).
CAS PubMed PubMed Central Article Google Scholar
Andrés, M. D. et al. Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes. Arthritis Rheumtol. 65, 732–742 (2014).
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