Frontera WR, Ochala J. Skeletal muscle: a brief review of structure and function. Calcif Tissue Int. 2015;96(3):183–95.

CAS  PubMed  Article  Google Scholar 

Sartori R, Romanello V, Sandri M. Mechanisms of muscle atrophy and hypertrophy: implications in health and disease. Nat Commun. 2021;12(1):330. A review summarizing the main molecular pathways involved in the regulation of muscle.

Lee YH, Kim SU, Song K, Park JY, Kim DY, Ahn SH, Lee BW, Kang ES, Cha BS, Han KH. Sarcopenia is associated with significant liver fibrosis independently of obesity and insulin resistance in nonalcoholic fatty liver disease: Nationwide surveys (KNHANES 2008-2011). Hepatology. 2016;63(3):776–86.

CAS  PubMed  Article  Google Scholar 

Prado CM, Purcell SA, Laviano A. Nutrition interventions to treat low muscle mass in cancer. J Cachexia Sarcopenia Muscle. 2020;11(2):366–80.

PubMed  PubMed Central  Article  Google Scholar 

Prado CM, Purcell SA, Alish C, Pereira SL, Deutz NE, Heyland DK, Goodpaster BH, Tappenden KA, Heymsfield SB. Implications of low muscle mass across the continuum of care: a narrative review. Ann Med. 2018;50(8):675–93.

PubMed  Article  Google Scholar 

Maddocks M, Hopkinson J, Conibear J, Reeves A, Shaw C, Fearon KC. Practical multimodal care for cancer cachexia. Curr Opin Support Palliat Care. 2016;10(4):298–305.

PubMed  PubMed Central  Article  Google Scholar 

Potgens SA, Sboarina M, Bindels LB. Polyunsaturated fatty acids, polyphenols, amino acids, prebiotics: can they help to tackle cancer cachexia and related inflammation? Curr Opin Clin Nutr Metab Care. 2018;21(6):458–64.

PubMed  Article  CAS  Google Scholar 

Bindels LB, Delzenne NM. Muscle wasting: the gut microbiota as a new therapeutic target? Int J Biochem Cell Biol. 2013;45(10):2186–90.

CAS  PubMed  Article  Google Scholar 

Bindels LB, Thissen JP. Nutrition in cancer patients with cachexia: a role for the gut microbiota? Clin Nutr Exp. 2016;6:74–82.

Article  Google Scholar 

Ziemons J, Smidt ML, Damink SO, Rensen SS. Gut microbiota and metabolic aspects of cancer cachexia. Best Pract Res Clin Endocrinol Metab. 2021;101508.

Genton L, Cani PD, Schrenzel J. Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting. Clin Nutr. 2015;34(3):341–9.

CAS  PubMed  Article  Google Scholar 

Berg G, Rybakova D, Fischer D, Cernava T, Vergès MC, Charles T, et al. Microbiome definition re-visited: old concepts and new challenges. Microbiome. 2020;8(1):103.

PubMed  PubMed Central  Article  Google Scholar 

Delzenne NM, Knudsen C, Beaumont M, Rodriguez J, Neyrinck AM, Bindels LB. Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut-liver axis. Proc Nutr Soc. 2019:1–10.

Makki K, Deehan EC, Walter J, Backhed F. The impact of dietary fiber on gut microbiota in host health and disease. Cell Host Microbe. 2018;23(6):705–15.

CAS  PubMed  Article  Google Scholar 

Valdes AM, Walter J, Segal E, Spector TD. Role of the gut microbiota in nutrition and health. BMJ. 2018;361:k2179. A review introducing key concepts in the gut microbiota field, how nutrition impacts the gut microbiota, and mechanisms through which the gut microbiota modulates host health.

Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14(8):491–502.

PubMed  Article  Google Scholar 

Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11:506–14.

PubMed  Article  Google Scholar 

Agus A, Planchais J, Sokol H. Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host Microbe. 2018;23(6):716–24.

CAS  PubMed  Article  Google Scholar 

Oliphant K, Allen-Vercoe E. Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health. Microbiome. 2019;7(1):91. A review describes in detail macronutrient metabolism by the gut microbiome and how the ensuing metabolites influence human health.

Postler TS, Ghosh S. Understanding the holobiont: how microbial metabolites affect human health and shape the immune system. Cell Metab. 2017;26(1):110–30.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA. 2004;101(44):15718–23.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Lahiri S, Kim H, Garcia-Perez I, Reza MM, Martin KA, Kundu P, et al. The gut microbiota influences skeletal muscle mass and function in mice. Sci Transl Med. 2019;11(502). This research article is the first one to provide a detailed characterization of the muscle of germ-free mice, compared to conventional and conventionalized mice, and to establish the beneficial impact of short-chain fatty acids on muscle mass and function.

Nay K, Jollet M, Goustard B, Baati N, Vernus B, Pontones M, et al. Gut bacteria are critical for optimal muscle function: a potential link with glucose homeostasis. Am J Physiol Endocrinol Metab. 2019. This research article contributes significantly to the evidence that gut microbiota modulates muscle function, as established through the administration of a broad spectrum antibiotics cocktail.

Bindels LB, Segura Munoz RR, Gomes-Neto JC, Mutemberezi V, Martinez I, Salazar N, et al. Resistant starch can improve insulin sensitivity independently of the gut microbiota. Microbiome. 2017;5(1):12.

PubMed  PubMed Central  Article  Google Scholar 

Zarrinpar A, Chaix A, Xu ZZ, Chang MW, Marotz CA, Saghatelian A, Knight R, Panda S. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat Commun. 2018;9(1):2872.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Huang WC, Chen YH, Chuang HL, Chiu CC, Huang CC. Investigation of the effects of microbiota on exercise physiological adaption, performance, and energy utilization using a gnotobiotic animal model. Front Microbiol. 2019;10:1906.

PubMed  PubMed Central  Article  Google Scholar 

Lee MC, Hsu YJ, Ho HH, Hsieh SH, Kuo YW, Sung HC, et al. Lactobacillus salivarius subspecies salicinius SA-03 is a new probiotic capable of enhancing exercise performance and decreasing fatigue. Microorganisms. 2020;8(4).

Chen YM, Wei L, Chiu YS, Hsu YJ, Tsai TY, Wang MF, Huang CC. Lactobacillus plantarum TWK10 supplementation improves exercise performance and increases muscle mass in mice. Nutrients. 2016;8(4):205.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Huang WC, Hsu YJ, Huang CC, Liu HC, Lee MC. Exercise training combined with Bifidobacterium longum OLP-01 supplementation improves exercise physiological adaption and performance. Nutrients. 2020;12(4).

Munukka E, Rintala A, Toivonen R, Nylund M, Yang B, Takanen A, Hänninen A, Vuopio J, Huovinen P, Jalkanen S, Pekkala S. Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice. ISME J. 2017;11(7):1667–79.

PubMed  PubMed Central  Article  Google Scholar 

Li G, Jin B, Fan Z. Mechanisms involved in gut microbiota regulation of skeletal muscle. Oxid Med Cell Longev. 2022;2022:2151191–15.

PubMed  PubMed Central  Google Scholar 

Giron M, Thomas M, Dardevet D, Chassard C, Savary-Auzeloux I. Gut microbes and muscle function: can probiotics make our muscles stronger? J Cachexia Sarcopenia Muscle. 2022. This review provides a summary of the impact of probiotics on muscle mass and function in mice and humans.

Fielding RA, Reeves AR, Jasuja R, Liu C, Barrett BB, Lustgarten MS. Muscle strength is increased in mice that are colonized with microbiota from high-functioning older adults. Exp Gerontol. 2019;127:110722.

PubMed  PubMed Central  Article  Google Scholar 

Buigues C, Fernandez-Garrido J, Pruimboom L, Hoogland AJ, Navarro-Martinez R, Martinez-Martinez M, et al. Effect of a prebiotic formulation on frailty syndrome: a randomized, double-blind clinical trial. Int J Mol Sci. 2016;17(6).

Fu SK, Tseng WC, Tseng KW, Lai CC, Tsai YC, Tai HL, et al. Effect of daily oral Lactobacillus plantarum PS128 on exercise capacity recovery after a half-marathon. Nutrients. 2021;13(11).

Reijnders D, Goossens GH, Hermes GDA, Smidt H, Zoetendal EG, Blaak EE. Short-term microbiota manipulation and forearm substrate metabolism in obese men: a randomized, double-blind, placebo-controlled trial. Obes Facts. 2018;11(4):318–26.

PubMed  PubMed Central  Article  Google Scholar 

Mitchell CM, Davy BM, Ponder MA, McMillan RP, Hughes MD, Hulver MW, et al. Prebiotic inulin supplementation and peripheral insulin sensitivity in adults at elevated risk for type 2 diabetes: a pilot randomized controlled trial. Nutrients. 2021;13(9).

Backhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci USA. 2007;104(3):979–84.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Rodriguez J, Delzenne NM. Modulation of the gut microbiota-adipose tissue-muscle interactions by prebiotics. J Endocrinol. 2021;249(1):R1–R23.

CAS  PubMed  Article  Google Scholar 

Canfora EE, Jocken JW, Blaak EE. Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol. 2015;11(10):577–91.

CAS  PubMed  Article  Google Scholar 

Canfora EE, Meex RCR, Venema K, Blaak EE. Gut microbial metabolites in obesity, NAFLD and T2DM. Nat Rev Endocrinol. 2019;15(5):261–73.

CAS  PubMed  Article  Google Scholar 

Dalile B, Van Oudenhove L, Vervliet B, Verbeke K. The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol. 2019;16(8):461–78.

PubMed  Article  Google Scholar 

Frampton J, Murphy KG, Frost G, Chambers ES. Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function. Nat Metab. 2020;2(9):840-8. This review provides an extensive summary of the impact of short-chain fatty acids on muscle.

Walsh ME, Bhattacharya A, Sataranatarajan K, Qaisar R, Sloane L, Rahman MM, Kinter M, van Remmen H. The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging. Aging Cell. 2015;14(6):957–70.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Scheiman J, Luber JM, Chavkin TA, MacDonald T, Tung A, Pham LD, et al. Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism. Nat Med. 2019;25(7):1104-9. This research article provides a mechanistic demonstration of the crosstalk between one specific microbe, Veillonella atypica, and the muscle upon exercise.

Chen F, Li Q, Chen Y, Wei Y, Liang J, Song Y, Shi L, Wang J, Mao L, Zhang B, Zhang Z. Association of the gut microbiota and fecal short-chain fatty acids with skeletal muscle mass and strength in children. FASEB J. 2022;36(1):e22109.

CAS  PubMed  Article  Google Scholar 

Lv WQ, Lin X, Shen H, Liu HM, Qiu X, Li BY, Shen WD, Ge CL, Lv FY, Shen J, Xiao HM, Deng HW. Human gut microbiome impacts skeletal muscle mass via gut microbial synthesis of the short-chain fatty acid butyrate among healthy menopausal women. J Cachexia Sarcopenia Muscle. 2021;12(6):1860–70.

PubMed  PubMed Central  Article  Google Scholar 

Thibaut MM, Bindels LB. Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation. Trends Mol Med. 2022;28(3):223-36. This review describes how gut microbes modulate bile acid metabolism and pathways.

Perino A, Demagny H, Velazquez-Villegas L, Schoonjans K. Molecular physiology of bile acid signaling in health, disease, and aging. Physiol Rev. 2021;101(2):683-731. Comprehensive review on bile acids, their metabolism, and their role in health, disease, and aging.