The Lactate Gradient, an unrecognized biomarker of potential significance

Abstract

Background: Human lactate formation is typically attributed to hypoxia, but it may actually be due to the influence of norepinephrine. Methods: A lactate gradient was measured from the first few drops of blood obtained after application of a lancet to a finger pad. However, the blood needed to be carefully obtained according to this protocol. Results: The measured lactate gradient was surprisingly large in some circumstances, and was not correlated with any of the other measured parameters such as oxygen or carbon dioxide blood levels. There were hints in the data that the lactate gradient seemed to be influenced by sympathetic noradrenergic nervous system activity. Conclusions: The lactate gradient is relatively easily obtainable, and may reflect conditions causing enhanced sympathetic activity.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

This work was made possible with equipment purchase support through a generous grant from the SSM Agnesian Foundation in obtaining the EPOC analyzer and associated test cartridges.

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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

SSM Agnesian Institutional Review Board gave ethical approval for this work.

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Data Availability

All data produced in the present work are contained in the manuscript.

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