Incidence, risk factors, and clinical impact of major bleeding in hospitalized patients with COVID-19: a sub-analysis of the CLOT-COVID Study

McGonagle D, O’Donnell JS, Sharif K, Emery P, Bridgewood C. Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia. Lancet Rheumatol. 2020;2:e437–45.

Article  Google Scholar 

Lorini FL, Di Matteo M, Gritti P, Grazioli L, Benigni A, Zacchetti L, et al. Coagulopathy and COVID-19. Eur Heart J Suppl. 2021;23:E95–8.

CAS  Article  Google Scholar 

Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JCT, Fogerty AE, Waheed A, et al. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood. 2020;136:489–500.

CAS  Article  Google Scholar 

Bikdeli B, Madhavan MV, Jimenez D, Chuich T, Dreyfus I, Driggin E, et al. COVID-19 and thrombotic or thromboembolic disease: Implications for prevention, antithrombotic therapy, and follow-up: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020;75:2950–73.

CAS  Article  Google Scholar 

Malas MB, Naazie IN, Elsayed N, Mathlouthi A, Marmor R, Clary B. Thromboembolism risk of COVID-19 is high and associated with a higher risk of mortality: A systematic review and meta-analysis. EClinicalMedicine. 2020;29:100639.

Article  Google Scholar 

Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. Journal of thrombosis and haemostasis : JTH. 2020;18(5):1023–6.

CAS  Article  Google Scholar 

Cuker A, Tseng EK, Nieuwlaat R, Angchaisuksiri P, Blair C, Dane K, et al. American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19. Blood Adv. 2021;5(3):872–88.

CAS  Article  Google Scholar 

Demelo-Rodriguez P, Farfan-Sedano AI, Pedrajas JM, Llamas P, Siguenza P, Jaras MJ, et al. Bleeding risk in hospitalized patients with COVID-19 receiving intermediate- or therapeutic doses of thromboprophylaxis. J Thromb Haemost. 2021;19:1981–9.

CAS  Article  Google Scholar 

Demelo-Rodriguez P, Galeano-Valle F, Ordieres-Ortega L, Siniscalchi C, Martin Del Pozo M, Fidalgo A, et al. Validation of a prognostic score to identify hospitalized patients with COVID-19 at increased risk for bleeding. Viruses. 2021;13. https://doi.org/10.3390/v13112278.

Al Raizah A, Al Askar A, Shaheen N, Aldosari K, Alnahdi M, Luhanga M, et al. High rate of bleeding and arterial thrombosis in COVID-19: Saudi multicenter study. Thromb J. 2021;19:13.

CAS  Article  Google Scholar 

Dalager-Pedersen M, Lund LC, Mariager T, Winther R, Hellfritzsch M, Larsen TB, et al. Venous thromboembolism and major bleeding in patients with coronavirus disease 2019 (COVID-19): A nationwide, population-based cohort study. Clin Infect Dis. 2021;73:2283–93.

CAS  Article  Google Scholar 

Nadkarni GN, Lala A, Bagiella E, Chang HL, Moreno PR, Pujadas E, et al. Anticoagulation, bleeding, mortality, and pathology in hospitalized patients with COVID-19. J Am Coll Cardiol. 2020;76:1815–26.

CAS  Article  Google Scholar 

Investigators A, Investigators AC-a, Investigators R-C, Lawler PR, Goligher EC, Berger JS, et al. Therapeutic anticoagulation with heparin in noncritically ill patients with Covid-19. N Engl J Med. 2021;385:790–802.

Article  Google Scholar 

Investigators R-C, Investigators AC-a, Investigators A, Goligher EC, Bradbury CA, McVerry BJ, et al. Therapeutic anticoagulation with heparin in critically ill patients with Covid-19. N Engl J Med. 2021;385:777–89.

Article  Google Scholar 

Zellmer S, Hanses F, Muzalyova A, Classen J, Braun G, Piepel C, et al. Gastrointestinal bleeding and endoscopic findings in critically and non-critically ill patients with corona virus disease 2019 (COVID-19): Results from Lean European Open Survey on SARS-CoV-2 (LEOSS) and COKA registries. United European Gastroenterol J. 2021;9:1081–90.

Article  Google Scholar 

Yamashita Y, Yachi S, Takeyama M, Nishimoto Y, Tsujino I, Nakamura J, et al. Influence of sex on development of thrombosis in patients with COVID-19: From the CLOT-COVID study. Thromb Res. 2022;213:173–8.

CAS  Article  Google Scholar 

Nishimoto Y, Yachi S, Takeyama M, Tsujino I, Nakamura J, Yamamoto N, et al. The current status of thrombosis and anticoagulation therapy in patients with COVID-19 in Japan: From the CLOT-COVID study. J Cardiol. 2022;In Press.

Sakamoto J, Yamashita Y, Morimoto T, Amano H, Takase T, Hiramori S, et al. Cancer-Associated Venous Thromboembolism in the Real World- From the COMMAND VTE Registry. Circ J. 2019;83(11):2271–81.

Article  Google Scholar 

Billett HH, Reyes-Gil M, Szymanski J, Ikemura K, Stahl LR, Lo Y, et al. Anticoagulation in COVID-19: Effect of enoxaparin, heparin, and apixaban on mortality. Thromb Haemost. 2020;120:1691–9.

Article  Google Scholar 

Schulman S, Kearon C. Subcommittee on Control of Anticoagulation of the S Standardization Committee of the International Society on T, Haemostasis Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost. 2005;3:692–4.

CAS  Article  Google Scholar 

Ortega-Paz L, Galli M, Capodanno D, Franchi F, Rollini F, Bikdeli B, et al. Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials. Eur Heart J Cardiovasc Pharmacother. 2021. https://doi.org/10.1093/ehjcvp/pvab070.

Decousus H, Tapson VF, Bergmann JF, Chong BH, Froehlich JB, Kakkar AK, et al. Factors at admission associated with bleeding risk in medical patients: findings from the IMPROVE investigators. Chest. 2011;139:69–79.

Article  Google Scholar 

Rees EM, Nightingale ES, Jafari Y, Waterlow NR, Clifford S, CA BP, et al. COVID-19 hospitalization duration: a systematic review and data synthesis. BMC Med. 2020;18:270.

CAS  Article  Google Scholar 

Williamson EJ, Walker AJ, Bhaskaran K, Bacon S, Bates C, Morton CE, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020;584:430–6.

CAS  Article  Google Scholar 

Li W, Xu Z, Xiang H, Zhang C, Guo Y, Xiong J. Risk factors for systemic and venous thromboembolism, mortality and bleeding risks in 1125 patients with COVID-19: relationship with anticoagulation status. Aging (Albany NY). 2021;13:9225–42.

Article  Google Scholar 

Shen L, Qiu L, Liu D, Wang L, Huang H, Ge H, et al. The association of low molecular weight heparin use and in-hospital mortality among patients hospitalized with COVID-19. Cardiovasc Drugs Ther. 2022;36:113–20.

CAS  Article  Google Scholar 

Halaby R, Cuker A, Yui J, Matthews A, Ishaaya E, Traxler E, et al. Bleeding risk by intensity of anticoagulation in critically ill patients with COVID-19: A retrospective cohort study. J Thromb Haemost. 2021;19:1533–45.

CAS  Article  Google Scholar 

Ward A, Sarraju A, Lee D, Bhasin K, Gad S, Beetel R, et al. COVID-19 is associated with higher risk of venous thrombosis, but not arterial thrombosis, compared with influenza: Insights from a large US cohort. PLoS ONE. 2022;17:e0261786.

CAS  Article  Google Scholar 

Chen J, Hang Y. Characteristics, risk factors and outcomes of gastrointestinal hemorrhage in COVID-19 patients: A meta-analysis. Pak J Med Sci. 2021;37:1524–31.

PubMed  PubMed Central  Google Scholar 

Marasco G, Maida M, Morreale GC, Licata M, Renzulli M, Cremon C, et al. Gastrointestinal bleeding in COVID-19 patients: A systematic review with meta-analysis. Can J Gastroenterol Hepatol. 2021;2021:2534975.

PubMed  PubMed Central  Google Scholar 

Alkhamis A, Alshamali Y, Alyaqout K, Lari E, Alkhamis MA, Althuwaini S, et al. Prevalence, predictors and outcomes of bleeding events in patients with COVID-19 infection on anticoagulation: Retrospective cohort study. Ann Med Surg (Lond). 2021;68:102567.

Article  Google Scholar 

Godier A, Clausse D, Meslin S, Bazine M, Lang E, Huche F, et al. Major bleeding complications in critically ill patients with COVID-19 pneumonia. J Thromb Thrombolysis. 2021;52:18–21.

CAS  Article  Google Scholar 

Piran S, Schulman S. Treatment of bleeding complications in patients on anticoagulant therapy. Blood. 2019;133:425–35.

CAS  Article  Google Scholar 

Lauzier F, Arnold DM, Rabbat C, Heels-Ansdell D, Zarychanski R, Dodek P, et al. Risk factors and impact of major bleeding in critically ill patients receiving heparin thromboprophylaxis. Intensive Care Med. 2013;39:2135–43.

CAS  Article  Google Scholar 

Mauro A, De Grazia F, Lenti MV, Penagini R, Frego R, Ardizzone S, et al. Upper gastrointestinal bleeding in COVID-19 inpatients: Incidence and management in a multicenter experience from Northern Italy. Clin Res Hepatol Gastroenterol. 2021;45: 101521.

CAS  Article  Google Scholar 

Musoke N, Lo KB, Albano J, Peterson E, Bhargav R, Gul F, et al. Anticoagulation and bleeding risk in patients with COVID-19. Thromb Res. 2020;196:227–30.

CAS  Article  Google Scholar 

Lawton MT, Alimohammadi E, Bagheri SR, Bostani A, Vaziri S, Karbasforoushan A, et al. Coronavirus disease 2019 (COVID-19) can predispose young to Intracerebral hemorrhage: a retrospective observational study. BMC Neurol. 2021;21:83.

CAS  Article  Google Scholar 

Kessler C, Stricker H, Demundo D, Elzi L, Monotti R, Bianchi G, et al. Bleeding prevalence in COVID-19 patients receiving intensive antithrombotic prophylaxis. J Thromb Thrombolysis. 2020;50:833–6.

CAS  Article  Google Scholar 

Yamashita Y, Maruyama Y, Satokawa H, Nishimoto Y, Tsujino I, Sakashita H, et al. Incidence and clinical features of venous thromboembolism in hospitalized patients with coronavirus disease 2019 (COVID-19) in Japan. Circulation. 2021;85:2208–14.

CAS  Article  Google Scholar 

Trindade AJ, Izard S, Coppa K, Hirsch JS, Lee C, Satapathy SK, et al. Gastrointestinal bleeding in hospitalized COVID-19 patients: a propensity score matched cohort study. J Intern Med. 2021;289:887–94.

CAS  Article  Google Scholar 

Zhao X, Tao M, Chen C, Zhang Y, Fu Y. Clinical features and factors associated with occult gastrointestinal bleeding in COVID-19 patients. Infect Drug Resist. 2021;14:4217–26.

CAS  Article  Google Scholar 

Al-Samkari H, Gupta S, Leaf RK, Wang W, Rosovsky RP, Brenner SK, et al. Thrombosis, bleeding, and the observational effect of early therapeutic anticoagulation on survival in critically ill patients with cOVID-19. Ann Intern Med. 2021;174:622–32.

Article  Google Scholar 

Guo A, Lu J, Tan H, Kuang Z, Luo Y, Yang T, et al. Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study. Sci Rep. 2021;11:7310.

CAS  Article  Google Scholar 

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