Ethics approval and consent to participate 

Ethics approval has been granted by the Institutional Review Board at Charité – Universitätsmedizin Berlin, reference number: EA2/284/21. The study will be carried out in accordance with the Helsinki Declaration and German Law. Written, informed consent to participate will be obtained from all participants.

Consent for publication 

Not applicable - no identifying images or other personal or clinical details of participants are presented here or will be presented in reports of the trial results.

Informed consent materials are available from the corresponding author on request.

Competing interests 

HN: Invests in exchange-traded funds that hold shares of various companies in the technology and healthcare sectors that do not gain financially from the publication of the manuscript, but might do so in some way in the future. He is a member of the Digital Health Working group of the German Network Health Service Research (DNVF).

MK: Invests in exchange-traded funds that hold shares of various companies in the technology and healthcare sectors. He is also holding stocks in organizations that do not gain financially from the publication of the manuscript, but might do so in some way in the future.

MBA: Invests in exchange-traded funds that hold shares of various companies in the technology and healthcare sectors that do not gain financially from the publication of the manuscript, but might do so in some way in the future.

MB: Myrto Bolanaki reports grants from Bundesministerium für Gesundheit (German Ministry of Health) during the conduct of the study, grants from Bundesministerium für Bildung und Forschung (German Ministry for Education and Research), grants from Thermo Fisher BRAHMS, grants from Roche Diagnostics outside the submitted work.

KS: Konrad Schmidt reports grants from the Deutsche Forschungsgemeinschaft (German Research Council) and the Innovationsfonds des Gemeinsamen Bundesausschuss (Federal Joint Committee of Germany).

SKP: None.

CH: Christoph Heintze reports grants from the Bundesministerium für Bildung und Forschung (German Ministry for Education and Research), Deutsche Forschungsgemeinschaft (German Research Council) and the Innovationsfonds des Gemeinsamen Bundesausschuss (Federal Joint Committee of Germany).

MM: M. Möckel has received grants from Health Care Research Projects and Biomarker Research and personal fees from Consulting outside the submitted work.

FB: F. Balzer reports grants from the German Federal Ministry of Education and Research, grants from the German Federal Ministry of Health, grants from Berlin Institute of Health, personal fees from Elsevier Publishing, grants from Hans Böckler Foundation, others from Robert Koch Institute, grants from Einstein Foundation, grants from Berlin University Alliance, personal fees from Medtronic, outside the submitted work.

AS: Prof. Slagman reports grants from Bundesministerium für Gesundheit (German Ministry of Health), during the conduct of the study. Grants from Deutsche Forschungsgemeinschaft (German Research Council), grants from Bundesministerium für Bildung und Forschung (German Ministry for Education and Research), grants from Innovationsfonds des Gemeinsamen Bundesausschuss (Federal Joint Committee of Germany), grants from Zentralinstitut für die Kassenärztliche Versorgung (Research Institute of Statutory Health Insurance Physicians in Germany), grants from Thermo Fisher Scientific, grants from Roche Diagnostics, personal fees from Biomarkers - Scientific Journal (Associate Editor), outside the submitted work.

MLS: Invests in exchange-traded funds that hold shares of various companies in the technology and healthcare sectors that do not gain financially from the publication of the manuscript, but might do so in some way in the future. In 2014 and 2015 he was an employee at Ada Health GmbH (formerly known as medx GmbH), the developer company of the investigated health application.