Clinical Engineering - Methods Article

Jahanbani A.a· Goodarzi M.b· Sajjadi Dezfouli S.M.c· Yourdkhani M.R.d· Eskandari Roozbahani N.e

Author affiliations

aDVM, Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
bDepartment of Electrical Engineering, Faculty of Engineering, Islamic Azad University, Garmsar Branch, Garmsar, Iran
cDVM, Resident of Veterinary Surgery, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
dAnalytical Chemistry Master, University of Mazandaran, Babolsar, Iran
eClinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

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Article / Publication Details

First-Page Preview

Received: November 05, 2021
Accepted: July 15, 2022
Published online: September 20, 2022

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 2

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: https://www.karger.com/BPU

Abstract

This in vitro experimental investigation aimed to provide a novel method for preventing blood clotting based on the electrochemical characteristics of blood. Using this method in cases such as dialysis can minimize the risk of blood clots and also avoid hemorrhagic risk for patients. Blood samples were collected from 13 sheep (45 kg) (25 mL), and the clotting time (CT) was measured using a 20-min cutoff after they were separated into control and experimental samples. The test blood sample was put in a cell designed with two aluminum electrodes (positive pole/anode) located in a container containing 0.9% sodium chloride (as a salt bridge) and a platinum (negative pole/cathode) linked to a power supply (−3.5 V, 1 mA/cm2). Biochemical and hematological tests to check blood damage and clotting were performed. The control sample coagulated after 8 min, while the electrified blood did not, even at the end of the cutoff time. Among hematologic and biochemical tests, the average time of prothrombin time (PT) and partial thromboplastin time (PTT) was significantly different between the control and test samples (p = 0.001). Our findings on electrified blood with expanding CT, PT, and PTT times revealed that the electric current passing through the blood enhanced the CT. Furthermore, no change in biochemical or hematological factors demonstrated that this current had no detrimental effect on the blood.

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First-Page Preview

Received: November 05, 2021
Accepted: July 15, 2022
Published online: September 20, 2022

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 2

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: https://www.karger.com/BPU

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