Abeliovich A, Schmitz Y, Farinas I, Choi-Lundberg D, Ho WH, Castillo PE et al (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25:239–252. https://doi.org/10.1016/s0896-6273(00)80886-7

CAS  Article  PubMed  Google Scholar 

Agarraberes FA, Dice JF (2001) A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J Cell Sci 114:2491–2499. https://doi.org/10.1242/jcs.114.13.2491

CAS  Article  PubMed  Google Scholar 

Anderson JP, Walker DE, Goldstein JM, de Laat R, Banducci K, Caccavello RJ et al (2006) Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J Biol Chem 281:29739–29752. https://doi.org/10.1074/jbc.M600933200

CAS  Article  PubMed  Google Scholar 

Azeredo da Silveira S, Schneider BL, Cifuentes-Diaz C, Sage D, Abbas-Terki T, Iwatsubo T et al (2009) Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson’s disease. Hum Mol Genet 18:872–887. https://doi.org/10.1093/hmg/ddn417

CAS  Article  PubMed  Google Scholar 

Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM, Trojanowski JQ, Iwatsubo T (1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 152: 879–884 http://www.ncbi.nlm.nih.gov/pubmed/9546347

Baldereschi M, Di Carlo A, Rocca WA, Vanni P, Maggi S, Perissinotto E et al (2000) Parkinson’s disease and parkinsonism in a longitudinal study: two-fold higher incidence in men. ILSA Working Group. Italian Longitudinal Study on Aging. Neurology 55:1358–1363. https://doi.org/10.1212/wnl.55.9.1358

CAS  Article  PubMed  Google Scholar 

Bartels T, Choi JG, Selkoe DJ (2011) alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 477:107–110. https://doi.org/10.1038/nature10324

CAS  Article  PubMed  PubMed Central  Google Scholar 

Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B 57:289–300. https://doi.org/10.1111/j.2517-6161.1995.tb02031.x

Article  Google Scholar 

Beraldo FH, Arantes CP, Santos TG, Queiroz NG, Young K, Rylett RJ et al (2010) Role of alpha7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1. J Biol Chem 285:36542–36550. https://doi.org/10.1074/jbc.M110.157263

CAS  Article  PubMed  PubMed Central  Google Scholar 

Beraldo FH, Ostapchenko VG, Xu JZ, Di Guglielmo GM, Fan J, Nicholls PJ et al (2018) Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex. J Neurochem 145:68–79. https://doi.org/10.1111/jnc.14281

CAS  Article  PubMed  PubMed Central  Google Scholar 

Beraldo FH, Palmer D, Memar S, Wasserman DI, Lee WV, Liang S et al (2019) MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment. Elife. https://doi.org/10.7554/eLife.49630

Article  PubMed  PubMed Central  Google Scholar 

Beraldo FH, Soares IN, Goncalves DF, Fan J, Thomas AA, Santos TG et al (2013) Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein. FASEB J 27:3594–3607. https://doi.org/10.1096/fj.13-232280

CAS  Article  PubMed  Google Scholar 

Beraldo FH, Thomas A, Kolisnyk B, Hirata PH, De Jaeger X, Martyn AC et al (2015) Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1). Dis Model Mech 8:1457–1466. https://doi.org/10.1242/dmm.022525

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bergeron M, Motter R, Tanaka P, Fauss D, Babcock M, Chiou SS et al (2014) In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 alpha-synuclein phosphorylation in mouse brain. Neuroscience 256:72–82. https://doi.org/10.1016/j.neuroscience.2013.09.061

CAS  Article  PubMed  Google Scholar 

Betemps D, Verchere J, Brot S, Morignat E, Bousset L, Gaillard D et al (2014) Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological alpha-synuclein by enhanced ELISA. Acta Neuropathol Commun 2:29. https://doi.org/10.1186/2051-5960-2-29

Article  PubMed  PubMed Central  Google Scholar 

Bhattacharya K, Weidenauer L, Luengo TM, Pieters EC, Echeverria PC, Bernasconi L et al (2020) The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation. Nat Commun 11:5975. https://doi.org/10.1038/s41467-020-19783-w

CAS  Article  PubMed  PubMed Central  Google Scholar 

Biebl MM, Riedl M, Buchner J (2020) Hsp90 co-chaperones form plastic genetic networks adapted to client maturation. Cell Rep 32:108063. https://doi.org/10.1016/j.celrep.2020.108063

CAS  Article  PubMed  Google Scholar 

Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O’Leary JC 3rd, Fontaine SN et al (2013) Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. J Clin Invest 123:4158–4169. https://doi.org/10.1172/JCI69003

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bohush A, Niewiadomska G, Weis S, Filipek A (2019) HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson’s Disease and Dementia with Lewy Bodies. J Parkinsons Dis 9:97–107. https://doi.org/10.3233/JPD-181443

CAS  Article  PubMed  PubMed Central  Google Scholar 

Brehme M, Voisine C, Rolland T, Wachi S, Soper JH, Zhu Y et al (2014) A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. Cell Rep 9:1135–1150. https://doi.org/10.1016/j.celrep.2014.09.042

CAS  Article  PubMed  PubMed Central  Google Scholar 

Burmann BM, Gerez JA, Matecko-Burmann I, Campioni S, Kumari P, Ghosh D et al (2020) Regulation of alpha-synuclein by chaperones in mammalian cells. Nature 577:127–132. https://doi.org/10.1038/s41586-019-1808-9

CAS  Article  PubMed  Google Scholar 

Burre J (2015) The synaptic function of alpha-synuclein. J Parkinsons Dis 5:699–713. https://doi.org/10.3233/JPD-150642

CAS  Article  PubMed  PubMed Central  Google Scholar 

Burre J, Sharma M, Sudhof TC (2014) alpha-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proc Natl Acad Sci USA 111:E4274-4283. https://doi.org/10.1073/pnas.1416598111

CAS  Article  PubMed  PubMed Central  Google Scholar 

Burre J, Sharma M, Tsetsenis T, Buchman V, Etherton MR, Sudhof TC (2010) Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 329:1663–1667. https://doi.org/10.1126/science.1195227

CAS  Article  PubMed  PubMed Central  Google Scholar 

Cahill LS, Laliberte CL, Ellegood J, Spring S, Gleave JA, Eede MC et al (2012) Preparation of fixed mouse brains for MRI. Neuroimage 60:933–939. https://doi.org/10.1016/j.neuroimage.2012.01.100

Article  PubMed  Google Scholar 

Cantuti-Castelvetri I, Klucken J, Ingelsson M, Ramasamy K, McLean PJ, Frosch MP et al (2005) Alpha-synuclein and chaperones in dementia with Lewy bodies. J Neuropathol Exp Neurol 64:1058–1066. https://doi.org/10.1097/01.jnen.0000190063.90440.69

CAS  Article  PubMed  Google Scholar 

Chakravarty MM, Steadman P, van Eede MC, Calcott RD, Gu V, Shaw P et al (2013) Performing label-fusion-based segmentation using multiple automatically generated templates. Hum Brain Mapp 34:2635–2654. https://doi.org/10.1002/hbm.22092

Article  PubMed  Google Scholar 

Chang HC, Nathan DF, Lindquist S (1997) In vivo analysis of the Hsp90 cochaperone Sti1 (p60). Mol Cell Biol 17:318–325. https://doi.org/10.1128/MCB.17.1.318

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chen L, Feany MB (2005) Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat Neurosci 8:657–663. https://doi.org/10.1038/nn1443

CAS  Article  PubMed  Google Scholar 

Chen L, Liu Y, Becher A, Diepold K, Schmid E, Fehn A et al (2020) Sildenafil triggers tumor lethality through altered expression of HSP90 and degradation of PKD2. Carcinogenesis 41:1421–1431. https://doi.org/10.1093/carcin/bgaa001

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chung HK, Ho HA, Perez-Acuna D, Lee SJ (2019) Modeling alpha-synuclein propagation with preformed fibril injections. J Mov Disord 12:139–151. https://doi.org/10.14802/jmd.19046

Article  PubMed  PubMed Central  Google Scholar 

Ciechanover A, Kwon YT (2017) Protein Quality Control by Molecular Chaperones in Neurodegeneration. Front Neurosci 11:185. https://doi.org/10.3389/fnins.2017.00185

Article  PubMed  PubMed Central  Google Scholar 

Conway KA, Harper JD, Lansbury PT (1998) Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat Med 4:1318–1320. https://doi.org/10.1038/3311

CAS  Article  PubMed  Google Scholar 

Conway KA, Lee SJ, Rochet JC, Ding TT, Williamson RE, Lansbury PT Jr (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson’s disease: implications for pathogenesis and therapy. Proc Natl Acad Sci USA 97:571–576. https://doi.org/10.1073/pnas.97.2.571

CAS  Article