Kumar J. Epidemiology of hypertension. Clinical Queries: Nephrology. 2013;2(2):56–61.

Article  Google Scholar 

Centers for Disease Control and Prevention, National Center for Health Statistics. Facts about hypertension. In: Centers for Disease Control and Prevention. 2021. https://www.cdc.gov/bloodpressure/facts.htm. Accessed 1 Sept 2021.

Kirkland EB, Heincelman M, Bishu KG, Schumann SO, Schreiner A, Axon RN, et al. Trends in healthcare expenditures among US adults with hypertension: national estimates, 2003–2014. J Am Heart Assoc. 2018;7(11):e008731.

PubMed  PubMed Central  Article  Google Scholar 

Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018;71(19):e127-248.

PubMed  Article  Google Scholar 

Launer LJ, Ross GW, Petrovitch H, Masaki K, Foley D, White LR, et al. Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol Aging. 2000;21(1):49–55.

CAS  PubMed  Article  Google Scholar 

Walker KA, Sharrett AR, Wu A, Schneider AL, Albert M, Lutsey PL, et al. Association of midlife to late-life blood pressure patterns with incident dementia. JAMA. 2019;322(6):535–45.

PubMed  PubMed Central  Article  Google Scholar 

Skoog I, Nilsson L, Persson G, Lernfelt B, Landahl S, Palmertz B, et al. 15-year longitudinal study of blood pressure and dementia. The Lancet. 1996;347(9009):1141–5.

CAS  Article  Google Scholar 

•• Ou YN, Tan CC, Shen XN, Xu W, Hou XH, Dong Q, et al. Blood pressure and risks of cognitive impairment and dementia: a systematic review and meta-analysis of 209 prospective studies. Hypertension. 2020;76(1):217–25. A systematic review and meta-analysis of 209 prospective studies shows complex relationships between BP variables and cognitive disorders depending on the age and BP type.

CAS  PubMed  Article  Google Scholar 

Qiu C, von Strauss E, Fastbom J, Winblad B, Fratiglioni L. Low blood pressure and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Arch Neurol. 2003;60(2):223–8.

PubMed  Article  Google Scholar 

Iadecola C, Yaffe K, Biller J, Bratzke LC, Faraci FM, Gorelick PB, et al. Impact of hypertension on cognitive function: a scientific statement from the American Heart Association. Hypertension. 2016;68(6):e67-94.

CAS  PubMed  Article  Google Scholar 

•• de Menezes ST, Giatti L, Brant LC, Griep RH, Schmidt MI, Duncan BB, et al. Hypertension, prehypertension, and hypertension control: association with decline in cognitive performance in the ELSA-Brasil cohort. Hypertension. 2021;77(2):672–81. A longitudinal study involving 7063 participants suggested that lower and older age of hypertension are associated with cognitive decline in different domains. It also suggested that blood pressure control might be critical for preservation of cognitive function.

PubMed  Article  Google Scholar 

Golimstok A, Cámpora N, Rojas JI, Fernandez MC, Elizondo C, Soriano E, et al. Cardiovascular risk factors and frontotemporal dementia: a case–control study. Transl Neurodegener. 2014;3(1):1–6.

Article  Google Scholar 

Tseng YF, Lin HC, Chao JC, Hsu CY, Lin HL. Calcium Channel blockers are associated with reduced risk of Parkinson’s disease in patients with hypertension: a population-based retrospective cohort study. J Neurol Sci. 2021;15(424):117412.

Article  CAS  Google Scholar 

Malek N, Lawton MA, Swallow DM, Grosset KA, Marrinan SL, Bajaj N, et al. Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson’s disease. Mov Disord. 2016;31(10):1518–26.

CAS  PubMed  PubMed Central  Article  Google Scholar 

•• Ho JK, Moriarty F, Manly JJ, Larson EB, Evans DA, Rajan KB, et al. Blood-brain barrier crossing renin-angiotensin drugs and cognition in the elderly: a meta-analysis. Hypertension. 2021 Jun 21:HYPERTENSIONAHA-121. A meta-analysis suggests links between blood-brain barrier crossing renin-angiotensin antihypertensive medications and less cognitive decline.

Graff-Radford J. Vascular cognitive impairment. Continuum (Minneap Minn). 2019;25(1):147.

Google Scholar 

• Sierra C. Hypertension and the risk of dementia. Frontiers in cardiovascular medicine. 2020;31(7):5. A review shows controversial results of different studies regarding the optimal systolic and diastolic blood pressure values for protecting cognitive functions in elderly people.

Article  Google Scholar 

Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ. 2010;26:341.

Google Scholar 

Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease: the Nun Study. JAMA. 1997;277(10):813–7.

CAS  PubMed  Article  Google Scholar 

Román GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, et al. Vascular dementia: diagnostic criteria for research studies: report of the NINDS-AIREN International Workshop. Neurology. 1993;43(2):250–60.

PubMed  Article  Google Scholar 

O’Brien J, Erkinjuntti T, Reisberg B, Roman G, Sawada T, Pantoni L, et al. Vascular cognitive impairment. Lancet Neurol. 2003;2(2):89–98.

PubMed  Article  Google Scholar 

Monica Moore MS, Díaz-Santos M, Vossel K. Alzheimer’s Association 2021 Facts and Figures Report.

Knopman DS, Parisi JE, Boeve BF, Cha RH, Apaydin H, Salviati A, et al. Vascular dementia in a population-based autopsy study. Arch Neurol. 2003;60(4):569–75.

PubMed  Article  Google Scholar 

Schneider JA, Aggarwal NT, Barnes L, Boyle P, Bennett DA. The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis. 2009;18(3):691–701.

PubMed  PubMed Central  Article  Google Scholar 

Cole SL, Vassar R. Linking vascular disorders and Alzheimer’s disease: potential involvement of BACE1. Neurobiol Aging. 2009;30(10):1535–44.

CAS  PubMed  Article  Google Scholar 

• Ungvari Z, Toth P, Tarantini S, Prodan CI, Sorond F, Merkely B, et al. Hypertension-induced cognitive impairment: from pathophysiology to public health. Nat Rev Nephrol. 2021;14:1–6. A review suggests that the use of pharmaceutical and lifestyle interventions that reduce blood pressure, in combination with treatments that promote microvascular health may have the potential in preventing or delaying the pathogenesis of vascular cognitive impairment and Alzheimer’s disease in patients with hypertension.

Google Scholar 

Liu W, Wong A, Law AC, Mok VC. Cerebrovascular disease, amyloid plaques, and dementia. Stroke. 2015;46(5):1402–7.

PubMed  Article  Google Scholar 

Carnevale D, Mascio G, Ajmone-Cat MA, D’Andrea I, Cifelli G, Madonna M, et al. Role of neuroinflammation in hypertension-induced brain amyloid pathology. Neurobiol Aging. 2012;33(1):205.e19-205.e29.

CAS  Article  Google Scholar 

Sadekova N, Iulita MF, Vallerand D, Muhire G, Bourmoum M, Claing A, et al. Arterial stiffness induced by carotid calcification leads to cerebral gliosis mediated by oxidative stress. J Hypertens. 2018;36(2):286–98.

CAS  PubMed  Article  Google Scholar 

Carnevale D, Lembo G. ‘Alzheimer-like’pathology in a murine model of arterial hypertension. Biochem Soc Trans. 2011;39(4):939–44.

CAS  PubMed  Article  Google Scholar 

Nasrabady SE, Rizvi B, Goldman JE, Brickman AM. White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes. Acta Neuropathol Commun. 2018;6(1):1–10.

Article  CAS  Google Scholar 

Welch KM, Caplan LR, Siesjo BK, Weir B, Reis DJ, editors. Primer on cerebrovascular diseases. Gulf Professional Publishing; 1997.

Van Beek AH, Claassen JA, Rikkert MG, Jansen RW. Cerebral autoregulation: an overview of current concepts and methodology with special focus on the elderly. J Cereb Blood Flow Metab. 2008;28(6):1071–85.

PubMed  Article  Google Scholar 

SS Meel-van den Abeelen A, Lagro J, HEA van Beek A, AHR Claassen J. Impaired cerebral autoregulation and vasomotor reactivity in sporadic Alzheimer’s disease. Curr Alzheimer Res. 2014;11(1):11–7.

Article  CAS  Google Scholar 

Zazulia AR, Videen TO, Morris JC, Powers WJ. Autoregulation of cerebral blood flow to changes in arterial pressure in mild Alzheimer’s disease. J Cereb Blood Flow Metab. 2010;30(11):1883–9.

PubMed  PubMed Central  Article  Google Scholar 

Claassen JA, Diaz-Arrastia R, Martin-Cook K, Levine BD, Zhang R. Altered cerebral hemodynamics in early Alzheimer disease: a pilot study using transcranial Doppler. J Alzheimers Dis. 2009;17(3):621–9.

PubMed  PubMed Central  Article  Google Scholar 

Claassen JA, Zhang R. Cerebral autoregulation in Alzheimer’s disease. J Cereb Blood Flow Metab. 2011;31(7):1572–7.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kennelly S, Collins O. Walking the cognitive “minefield” between high and low blood pressure. J Alzheimers Dis. 2012;32(3):609–21.

PubMed  Article  CAS  Google Scholar 

Novak V, Hajjar I. The relationship between blood pressure and cognitive function. Nat Rev Cardiol. 2010;7(12):686–98.

PubMed  PubMed Central  Article  Google Scholar 

Kennelly SP, Lawlor BA, Kenny RA. Blood pressure and the risk for dementia—a double edged sword. Ageing Res Rev. 2009;8(2):61–70.

PubMed  Article  Google Scholar 

Skoog I. The relationship between blood pressure and dementia: a review. Biomed Pharmacother. 1997;51(9):367–75.

CAS  PubMed  Article  Google Scholar 

Skoog I, Gustafson D. Update on hypertension and Alzheimer’s disease. Neurol Res. 2006;28(6):605–11.

PubMed  Article  Google Scholar 

Kivipelto M, Helkala EL, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, et al. Midlife vascular risk factors and Alzheimer’s disease in later life: longitudinal, population based study. BMJ. 2001;322(7300):1447–51.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Liu Y, Dong YH