Biography—Mikhail Kolonin

Mikhail Kolonin, Ph.D., is a tenured professor and the Harry E. Bovay, Jr. Distinguished University Chair in Metabolic Disease at the University of Houston Texas McGovern Medical School. He received his Ph.D. in molecular medicine from Wayne State University School of Medicine where he pioneered the concept of expressing peptides designed to disrupt protein interactions in animals. As a postdoctoral fellow at M.D. Anderson Cancer Center, he screened combinatorial libraries in mice and cancer patients to identify peptides targeting tissue-specific cell surface protein interactions. As a result, he identified tissue-specific cell surface markers that have been pursued as drug targets. Based on this technology, Dr. Kolonin has invented several experimental therapeutics targeting specific cell populations implicated in obesity and cancer. The main interest of his laboratory converges on the multifaceted roles of stromal cells from fat tissue in healthy metabolism and in pathology. Specifically, Dr. Kolonin’s group has dissected the heterogeneity of adipose stromal cells giving rise to white and brown adipocytes and discovered that in obesity adipose stromal cells become recruited by carcinomas as progenitors of cancer-associated fibroblasts. Research of his laboratory also spans other aspects of intercellular interactions in adipose tissue and tumors, focusing on cytokine signaling, long-chain fatty acid transport and utilization, as well as the origins and the role of cell senescence in cancer and other aging-associated diseases. Currently, Dr. Kolonin serves as the Director of the Center for Metabolic and Degenerative Diseases at the Institute for Molecular Medicine at UTHealth.

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